Motif ID: E2f6

Z-value: 1.394


Transcription factors associated with E2f6:

Gene SymbolEntrez IDGene Name
E2f6 ENSMUSG00000057469.7 E2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f6mm10_v2_chr12_+_16810940_168109780.681.3e-10Click!


Activity profile for motif E2f6.

activity profile for motif E2f6


Sorted Z-values histogram for motif E2f6

Sorted Z-values for motif E2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 31.674 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr15_-_98004695 24.445 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr15_-_98004634 23.797 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr2_+_71529085 20.915 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chr17_-_35516780 13.420 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
 Tcf19


transcription factor 19


chr13_+_48261427 12.975 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr6_+_108660616 12.792 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr7_-_38107490 11.938 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr19_-_45742873 11.479 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr7_+_102441685 11.100 ENSMUST00000033283.9
 Rrm1
ribonucleotide reductase M1
chr9_+_65890237 10.826 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr4_-_137796350 10.567 ENSMUST00000030551.4
 Alpl
alkaline phosphatase, liver/bone/kidney
chr1_+_74391479 10.535 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr13_-_29984219 10.407 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr2_-_172940299 10.253 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr2_-_71546745 10.145 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr1_-_172206775 9.997 ENSMUST00000013842.5
ENSMUST00000111247.1
 Pea15a

phosphoprotein enriched in astrocytes 15A

chr6_+_108660772 9.993 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr7_+_19094594 9.838 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr12_-_56536895 9.794 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 423 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.2 62.2 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
1.3 40.0 GO:0006270 DNA replication initiation(GO:0006270)
13.3 39.9 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
2.0 31.7 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
2.0 30.0 GO:0007530 sex determination(GO:0007530)
1.1 28.4 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.5 22.5 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
7.3 21.8 GO:0030421 defecation(GO:0030421)
0.8 20.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
2.3 18.8 GO:0044027 hypermethylation of CpG island(GO:0044027)
4.4 17.5 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
5.5 16.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
2.3 14.1 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
2.8 13.9 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.7 13.8 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.2 13.8 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
2.7 13.7 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
6.8 13.6 GO:0072180 mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
3.4 13.6 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.5 13.6 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 60.6 GO:0005634 nucleus(GO:0005634)
4.0 52.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 43.6 GO:0005667 transcription factor complex(GO:0005667)
0.3 36.6 GO:0005884 actin filament(GO:0005884)
0.0 34.6 GO:0005730 nucleolus(GO:0005730)
5.2 26.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.5 20.9 GO:0005657 replication fork(GO:0005657)
0.4 20.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.2 18.0 GO:0042555 MCM complex(GO:0042555)
0.8 17.8 GO:0001741 XY body(GO:0001741)
0.1 17.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 15.9 GO:0031526 brush border membrane(GO:0031526)
0.8 15.8 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.2 14.7 GO:0005844 polysome(GO:0005844)
0.2 14.6 GO:0032432 actin filament bundle(GO:0032432)
0.6 12.5 GO:0030894 replisome(GO:0030894)
1.7 11.9 GO:0001740 Barr body(GO:0001740)
2.0 11.8 GO:0044294 dendritic growth cone(GO:0044294)
0.6 10.7 GO:0071564 npBAF complex(GO:0071564)
0.7 10.6 GO:0046658 anchored component of plasma membrane(GO:0046658)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 256 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 49.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 47.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.4 40.0 GO:0005178 integrin binding(GO:0005178)
1.1 36.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
5.2 26.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
3.8 22.8 GO:0043426 MRF binding(GO:0043426)
1.0 22.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.7 22.3 GO:0071837 HMG box domain binding(GO:0071837)
2.4 19.1 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.4 19.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.6 17.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 15.7 GO:0001047 core promoter binding(GO:0001047)
0.1 15.0 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.6 14.8 GO:0008432 JUN kinase binding(GO:0008432)
2.1 14.6 GO:0034056 estrogen response element binding(GO:0034056)
0.3 14.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.4 14.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.2 14.1 GO:0003678 DNA helicase activity(GO:0003678)
0.2 14.1 GO:0008083 growth factor activity(GO:0008083)
0.2 13.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)