Motif ID: E2f7

Z-value: 1.603


Transcription factors associated with E2f7:

Gene SymbolEntrez IDGene Name
E2f7 ENSMUSG00000020185.10 E2f7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.819.9e-18Click!


Activity profile for motif E2f7.

activity profile for motif E2f7


Sorted Z-values histogram for motif E2f7

Sorted Z-values for motif E2f7



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f7

PNG image of the network

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Top targets:


Showing 1 to 20 of 110 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_116308241 29.350 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr9_+_3013140 21.340 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3037111 20.666 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr10_-_69352886 19.798 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr9_+_3025417 18.757 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr12_+_24708984 18.093 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr15_+_102296256 17.097 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr2_+_72476159 16.933 ENSMUST00000102691.4
 Cdca7
cell division cycle associated 7
chr2_+_72476225 16.403 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr4_+_108579445 16.369 ENSMUST00000102744.3
 Orc1
origin recognition complex, subunit 1
chr9_+_3017408 16.126 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 16.038 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr11_+_102248842 15.418 ENSMUST00000100392.4
 BC030867
cDNA sequence BC030867
chr12_+_24708241 14.214 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr8_+_75109528 13.246 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr2_-_157204483 12.725 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr13_-_100775844 12.359 ENSMUST00000075550.3
 Cenph
centromere protein H
chr10_+_3973086 11.534 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr3_+_108383829 11.387 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
 Psrc1


proline/serine-rich coiled-coil 1


chr17_-_35516780 11.132 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
 Tcf19


transcription factor 19



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 32.3 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
4.9 29.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 24.1 GO:0006915 apoptotic process(GO:0006915)
1.9 17.1 GO:1901970 positive regulation of mitotic sister chromatid separation(GO:1901970)
4.1 16.4 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
1.2 16.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.8 16.0 GO:0090166 Golgi disassembly(GO:0090166)
2.0 15.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.6 13.2 GO:0006270 DNA replication initiation(GO:0006270)
0.3 12.6 GO:0043550 regulation of lipid kinase activity(GO:0043550)
2.3 11.5 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.6 11.4 GO:0060236 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.4 11.1 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
1.5 10.3 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.7 10.3 GO:0051382 kinetochore assembly(GO:0051382)
0.3 9.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.5 9.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.8 9.0 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.4 8.5 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.4 7.8 GO:0021924 cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 36.9 GO:0072686 mitotic spindle(GO:0072686)
6.5 32.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.7 29.4 GO:0005915 zonula adherens(GO:0005915)
0.1 28.6 GO:0005667 transcription factor complex(GO:0005667)
3.2 25.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
1.3 18.6 GO:0042555 MCM complex(GO:0042555)
0.5 16.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 12.8 GO:0000922 spindle pole(GO:0000922)
0.0 12.3 GO:0005730 nucleolus(GO:0005730)
0.7 9.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 7.3 GO:0005811 lipid particle(GO:0005811)
0.6 7.0 GO:0000124 SAGA complex(GO:0000124)
2.2 6.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 5.7 GO:0000776 kinetochore(GO:0000776)
0.1 5.3 GO:0000786 nucleosome(GO:0000786)
1.6 4.8 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.1 4.5 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.2 4.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 3.7 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.5 3.4 GO:0005638 lamin filament(GO:0005638)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.5 32.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.7 32.1 GO:0070097 delta-catenin binding(GO:0070097)
2.8 22.2 GO:0003688 DNA replication origin binding(GO:0003688)
1.0 19.2 GO:0035173 histone kinase activity(GO:0035173)
0.1 17.6 GO:0001047 core promoter binding(GO:0001047)
2.6 15.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 14.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 13.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.7 12.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
2.9 11.5 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.3 9.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 9.6 GO:0031072 heat shock protein binding(GO:0031072)
0.0 9.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.4 8.7 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.8 8.5 GO:0030957 Tat protein binding(GO:0030957)
0.1 8.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
2.0 7.8 GO:0043515 kinetochore binding(GO:0043515)
0.2 7.3 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.1 7.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 7.1 GO:0008017 microtubule binding(GO:0008017)