Motif ID: E2f8

Z-value: 2.123


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.942.4e-33Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

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Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_75109528 38.243 ENSMUST00000164309.1
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr17_+_56303321 34.174 ENSMUST00000001258.8
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr7_-_115824699 31.901 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr12_+_24708984 30.556 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr17_+_56040350 30.266 ENSMUST00000002914.8
Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr11_-_89302545 30.026 ENSMUST00000061728.3
Nog
noggin
chr17_+_56303396 29.948 ENSMUST00000113038.1
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr11_-_101785252 27.700 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr6_-_94700137 27.259 ENSMUST00000101126.2
ENSMUST00000032105.4
Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr11_+_98907801 26.789 ENSMUST00000092706.6
Cdc6
cell division cycle 6
chr2_-_34913976 25.971 ENSMUST00000028232.3
Phf19
PHD finger protein 19
chr9_-_36726374 25.945 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
Chek1


checkpoint kinase 1


chr8_+_40926220 24.956 ENSMUST00000034004.9
Pdgfrl
platelet-derived growth factor receptor-like
chr7_-_48881032 24.766 ENSMUST00000058745.8
E2f8
E2F transcription factor 8
chr5_+_123749696 24.655 ENSMUST00000031366.7
Kntc1
kinetochore associated 1
chr1_-_128359610 24.606 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr12_+_24708241 23.360 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr16_-_18811615 23.125 ENSMUST00000096990.3
Cdc45
cell division cycle 45
chr6_-_88898664 22.320 ENSMUST00000058011.6
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr7_-_48881596 22.029 ENSMUST00000119223.1
E2f8
E2F transcription factor 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.4 95.9 GO:0010216 maintenance of DNA methylation(GO:0010216)
3.0 65.0 GO:0006270 DNA replication initiation(GO:0006270)
4.6 59.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
5.4 53.9 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
15.6 46.8 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
5.3 32.1 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
2.9 31.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.0 30.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
7.5 30.0 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
4.6 27.7 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
9.1 27.3 GO:0032474 otolith morphogenesis(GO:0032474)
3.7 26.0 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
7.7 23.1 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
2.2 22.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
2.7 21.7 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.4 20.6 GO:1902850 mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.1 19.6 GO:0006260 DNA replication(GO:0006260)
0.1 19.2 GO:0030010 establishment of cell polarity(GO:0030010)
0.9 16.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 16.4 GO:0006897 endocytosis(GO:0006897)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 118.7 GO:0005657 replication fork(GO:0005657)
6.4 96.5 GO:0042555 MCM complex(GO:0042555)
0.2 86.2 GO:0005667 transcription factor complex(GO:0005667)
10.8 53.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.1 31.8 GO:0005721 pericentric heterochromatin(GO:0005721)
10.1 30.3 GO:0033186 CAF-1 complex(GO:0033186)
1.4 30.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
8.2 24.7 GO:1990423 RZZ complex(GO:1990423)
0.0 24.0 GO:0005730 nucleolus(GO:0005730)
7.7 23.1 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
3.1 21.7 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.7 21.3 GO:0051233 spindle midzone(GO:0051233)
4.1 20.6 GO:0031523 Myb complex(GO:0031523)
0.1 19.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
3.1 18.3 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 17.0 GO:0005615 extracellular space(GO:0005615)
1.2 15.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 14.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
2.3 11.6 GO:0035189 Rb-E2F complex(GO:0035189)
3.8 11.3 GO:0043625 delta DNA polymerase complex(GO:0043625)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.5 83.7 GO:0003688 DNA replication origin binding(GO:0003688)
21.4 64.1 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
10.8 53.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 52.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.3 46.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7 36.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
5.2 36.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 31.8 GO:0004386 helicase activity(GO:0004386)
3.8 30.3 GO:0070087 chromo shadow domain binding(GO:0070087)
0.9 26.9 GO:0017025 TBP-class protein binding(GO:0017025)
8.6 25.9 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.3 22.8 GO:0019955 cytokine binding(GO:0019955)
7.2 21.7 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.3 19.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 18.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
1.7 18.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 17.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.3 17.3 GO:0035064 methylated histone binding(GO:0035064)
0.1 15.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.8 14.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)