Motif ID: E2f8
Z-value: 2.123

Transcription factors associated with E2f8:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
E2f8 | ENSMUSG00000046179.11 | E2f8 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
E2f8 | mm10_v2_chr7_-_48881596_48881619 | 0.94 | 2.4e-33 | Click! |
Top targets:
Showing 1 to 20 of 87 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 45 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
6.4 | 95.9 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
3.0 | 65.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
4.6 | 59.2 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
5.4 | 53.9 | GO:0009186 | deoxyribonucleoside diphosphate metabolic process(GO:0009186) |
15.6 | 46.8 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
5.3 | 32.1 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
2.9 | 31.9 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
1.0 | 30.3 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
7.5 | 30.0 | GO:2000313 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) |
4.6 | 27.7 | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation(GO:0033600) |
9.1 | 27.3 | GO:0032474 | otolith morphogenesis(GO:0032474) |
3.7 | 26.0 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
7.7 | 23.1 | GO:0036388 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
2.2 | 22.0 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
2.7 | 21.7 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
0.4 | 20.6 | GO:1902850 | mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850) |
0.1 | 19.6 | GO:0006260 | DNA replication(GO:0006260) |
0.1 | 19.2 | GO:0030010 | establishment of cell polarity(GO:0030010) |
0.9 | 16.7 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
0.0 | 16.4 | GO:0006897 | endocytosis(GO:0006897) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 34 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.8 | 118.7 | GO:0005657 | replication fork(GO:0005657) |
6.4 | 96.5 | GO:0042555 | MCM complex(GO:0042555) |
0.2 | 86.2 | GO:0005667 | transcription factor complex(GO:0005667) |
10.8 | 53.9 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
1.1 | 31.8 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
10.1 | 30.3 | GO:0033186 | CAF-1 complex(GO:0033186) |
1.4 | 30.0 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
8.2 | 24.7 | GO:1990423 | RZZ complex(GO:1990423) |
0.0 | 24.0 | GO:0005730 | nucleolus(GO:0005730) |
7.7 | 23.1 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
3.1 | 21.7 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
0.7 | 21.3 | GO:0051233 | spindle midzone(GO:0051233) |
4.1 | 20.6 | GO:0031523 | Myb complex(GO:0031523) |
0.1 | 19.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
3.1 | 18.3 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
0.0 | 17.0 | GO:0005615 | extracellular space(GO:0005615) |
1.2 | 15.0 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
0.1 | 14.8 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
2.3 | 11.6 | GO:0035189 | Rb-E2F complex(GO:0035189) |
3.8 | 11.3 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 35 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
10.5 | 83.7 | GO:0003688 | DNA replication origin binding(GO:0003688) |
21.4 | 64.1 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
10.8 | 53.9 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
0.1 | 52.5 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
0.3 | 46.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.7 | 36.9 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
5.2 | 36.5 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
0.2 | 31.8 | GO:0004386 | helicase activity(GO:0004386) |
3.8 | 30.3 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
0.9 | 26.9 | GO:0017025 | TBP-class protein binding(GO:0017025) |
8.6 | 25.9 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
0.3 | 22.8 | GO:0019955 | cytokine binding(GO:0019955) |
7.2 | 21.7 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
0.3 | 19.8 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
0.4 | 18.7 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
1.7 | 18.3 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
0.2 | 17.9 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
0.3 | 17.3 | GO:0035064 | methylated histone binding(GO:0035064) |
0.1 | 15.0 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
0.8 | 14.3 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |