Motif ID: E2f8

Z-value: 2.123


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.942.4e-33Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_75109528 38.243 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr17_+_56303321 34.174 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr7_-_115824699 31.901 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr12_+_24708984 30.556 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr17_+_56040350 30.266 ENSMUST00000002914.8
 Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr11_-_89302545 30.026 ENSMUST00000061728.3
 Nog
noggin
chr17_+_56303396 29.948 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr11_-_101785252 27.700 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr6_-_94700137 27.259 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr11_+_98907801 26.789 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chr2_-_34913976 25.971 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr9_-_36726374 25.945 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr8_+_40926220 24.956 ENSMUST00000034004.9
 Pdgfrl
platelet-derived growth factor receptor-like
chr7_-_48881032 24.766 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr5_+_123749696 24.655 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr1_-_128359610 24.606 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr12_+_24708241 23.360 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr16_-_18811615 23.125 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr6_-_88898664 22.320 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr7_-_48881596 22.029 ENSMUST00000119223.1
 E2f8
E2F transcription factor 8
chr2_+_163054682 20.580 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr7_+_110122299 19.155 ENSMUST00000033326.8
 Wee1
WEE 1 homolog 1 (S. pombe)
chr2_+_145785980 17.356 ENSMUST00000110005.1
ENSMUST00000094480.4
 Rin2

Ras and Rab interactor 2

chr19_+_38931008 16.830 ENSMUST00000145051.1
 Hells
helicase, lymphoid specific
chr4_+_132768325 16.710 ENSMUST00000102561.4
 Rpa2
replication protein A2
chr10_-_21160925 15.932 ENSMUST00000020158.6
 Myb
myeloblastosis oncogene
chr11_+_26387194 14.994 ENSMUST00000109509.1
ENSMUST00000136830.1
 Fancl

Fanconi anemia, complementation group L

chr19_+_38930909 14.975 ENSMUST00000025965.5
 Hells
helicase, lymphoid specific
chr2_-_157204483 14.267 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr15_+_78926720 13.976 ENSMUST00000089377.5
 Lgals1
lectin, galactose binding, soluble 1
chr16_-_46496772 13.870 ENSMUST00000149901.1
ENSMUST00000096052.2
 Pvrl3

poliovirus receptor-related 3

chr6_+_117916981 13.705 ENSMUST00000179478.1
 Hnrnpf
heterogeneous nuclear ribonucleoprotein F
chr16_-_46496955 13.576 ENSMUST00000023335.6
ENSMUST00000023334.8
 Pvrl3

poliovirus receptor-related 3

chr6_+_117917281 13.148 ENSMUST00000180020.1
ENSMUST00000177570.1
 Hnrnpf

heterogeneous nuclear ribonucleoprotein F

chr5_-_33652296 12.959 ENSMUST00000151081.1
ENSMUST00000101354.3
 Slbp

stem-loop binding protein

chr10_+_128015157 12.391 ENSMUST00000178041.1
ENSMUST00000026461.7
 Prim1

DNA primase, p49 subunit

chr16_-_15637277 12.284 ENSMUST00000023353.3
 Mcm4
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
chr7_-_44548733 11.294 ENSMUST00000145956.1
ENSMUST00000049343.8
 Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr13_+_19623163 11.133 ENSMUST00000002883.5
 Sfrp4
secreted frizzled-related protein 4
chr5_+_137787769 9.993 ENSMUST00000035852.7
 Zcwpw1
zinc finger, CW type with PWWP domain 1
chr5_+_111581422 9.825 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr5_-_65335597 9.456 ENSMUST00000172660.1
ENSMUST00000172732.1
ENSMUST00000031092.8
 Rfc1


replication factor C (activator 1) 1


chr15_+_55557399 9.161 ENSMUST00000022998.7
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr5_-_65335564 8.878 ENSMUST00000172780.1
 Rfc1
replication factor C (activator 1) 1
chr16_+_10835046 8.805 ENSMUST00000037913.8
 Rmi2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr5_-_33652339 8.715 ENSMUST00000075670.6
 Slbp
stem-loop binding protein
chr9_+_103305156 8.649 ENSMUST00000035164.3
 Topbp1
topoisomerase (DNA) II binding protein 1
chr5_+_129020069 7.648 ENSMUST00000031383.7
ENSMUST00000111343.1
 Ran

RAN, member RAS oncogene family

chr13_+_94875600 7.594 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr2_-_84743655 7.584 ENSMUST00000181711.1
 Gm19426
predicted gene, 19426
chr4_-_129189600 7.234 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein

chr4_-_129189646 6.406 ENSMUST00000106059.1
 S100pbp
S100P binding protein
chr15_+_55557575 6.247 ENSMUST00000170046.1
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr2_-_154569720 6.193 ENSMUST00000000894.5
 E2f1
E2F transcription factor 1
chr16_-_18248697 6.134 ENSMUST00000115645.3
 Ranbp1
RAN binding protein 1
chr4_-_129189512 6.127 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
 S100pbp


S100P binding protein


chr7_-_27337667 5.696 ENSMUST00000038618.6
ENSMUST00000108369.2
 Ltbp4

latent transforming growth factor beta binding protein 4

chr1_+_131910458 5.479 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr2_-_154569845 5.424 ENSMUST00000103145.4
 E2f1
E2F transcription factor 1
chr9_-_35116804 5.279 ENSMUST00000034537.6
 St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr10_+_42860348 5.065 ENSMUST00000063063.7
 Scml4
sex comb on midleg-like 4 (Drosophila)
chr7_+_102065713 4.827 ENSMUST00000094129.2
ENSMUST00000094130.2
ENSMUST00000084843.3
 Trpc2


transient receptor potential cation channel, subfamily C, member 2


chr5_+_150673739 3.825 ENSMUST00000016569.4
ENSMUST00000038900.8
 Pds5b

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

chr7_+_102065485 3.601 ENSMUST00000106950.1
ENSMUST00000146450.1
 Trpc2

transient receptor potential cation channel, subfamily C, member 2

chr13_+_44731281 3.599 ENSMUST00000174086.1
 Jarid2
jumonji, AT rich interactive domain 2
chr12_+_110279228 3.088 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chrX_-_73716145 3.008 ENSMUST00000002091.5
 Bcap31
B cell receptor associated protein 31
chr6_+_35177386 2.782 ENSMUST00000043815.9
 Nup205
nucleoporin 205
chr6_+_35177610 2.618 ENSMUST00000170234.1
 Nup205
nucleoporin 205
chr13_+_44731265 2.442 ENSMUST00000173246.1
 Jarid2
jumonji, AT rich interactive domain 2
chr11_+_21572221 2.357 ENSMUST00000020568.3
ENSMUST00000131135.1
 Wdpcp

WD repeat containing planar cell polarity effector

chr6_+_29348069 2.296 ENSMUST00000173216.1
ENSMUST00000031779.10
ENSMUST00000090481.7
 Calu


calumenin


chr3_-_127553233 2.163 ENSMUST00000029588.5
 Larp7
La ribonucleoprotein domain family, member 7
chrX_+_73716712 1.838 ENSMUST00000114461.2
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chrX_+_73716577 1.774 ENSMUST00000002084.7
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr2_-_18048784 1.245 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chr6_-_87851011 1.170 ENSMUST00000113617.1
 Cnbp
cellular nucleic acid binding protein
chr6_+_38551786 0.984 ENSMUST00000161227.1
 Luc7l2
LUC7-like 2 (S. cerevisiae)
chr10_-_128525859 0.933 ENSMUST00000026427.6
 Esyt1
extended synaptotagmin-like protein 1
chr11_-_21572193 0.767 ENSMUST00000102874.4
 Mdh1
malate dehydrogenase 1, NAD (soluble)
chr8_-_109737714 0.702 ENSMUST00000093162.3
 Atxn1l
ataxin 1-like
chr10_+_116301374 0.702 ENSMUST00000092167.5
 Ptprb
protein tyrosine phosphatase, receptor type, B
chr1_-_168431695 0.398 ENSMUST00000176790.1
 Pbx1
pre B cell leukemia homeobox 1
chr11_+_77462325 0.307 ENSMUST00000102493.1
 Coro6
coronin 6
chr9_+_22003035 0.114 ENSMUST00000115331.2
ENSMUST00000003493.7
 Prkcsh

protein kinase C substrate 80K-H

chr17_+_33909577 0.095 ENSMUST00000170075.2
 Daxx
Fas death domain-associated protein
chr17_+_33909481 0.043 ENSMUST00000173626.1
ENSMUST00000174541.1
 Daxx

Fas death domain-associated protein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
15.6 46.8 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
9.1 27.3 GO:0032474 otolith morphogenesis(GO:0032474)
7.7 23.1 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
7.5 30.0 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
6.4 95.9 GO:0010216 maintenance of DNA methylation(GO:0010216)
5.4 53.9 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
5.3 32.1 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
4.6 27.7 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
4.6 59.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
4.1 12.4 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
3.9 11.6 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
3.7 11.1 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174)
3.7 26.0 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
3.1 15.4 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
3.0 65.0 GO:0006270 DNA replication initiation(GO:0006270)
2.9 31.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
2.8 14.0 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
2.7 21.7 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
2.2 22.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
1.9 11.3 GO:0006287 base-excision repair, gap-filling(GO:0006287)
1.7 8.4 GO:0002121 inter-male aggressive behavior(GO:0002121) response to pheromone(GO:0019236)
1.5 7.6 GO:1902570 protein localization to nucleolus(GO:1902570)
1.2 3.6 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
1.0 3.0 GO:1904154 protein localization to endoplasmic reticulum exit site(GO:0070973) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
1.0 30.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.9 16.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.5 7.6 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.5 3.1 GO:0019336 phenol-containing compound catabolic process(GO:0019336)
0.5 5.4 GO:0000059 protein import into nucleus, docking(GO:0000059)
0.4 20.6 GO:1902850 mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.3 5.5 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628)
0.3 14.3 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.3 8.6 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.3 5.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 2.2 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.2 3.8 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.2 2.4 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.2 15.8 GO:0098792 xenophagy(GO:0098792)
0.1 19.2 GO:0030010 establishment of cell polarity(GO:0030010)
0.1 0.7 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.1 8.9 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.1 19.6 GO:0006260 DNA replication(GO:0006260)
0.0 1.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 5.7 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179)
0.0 16.4 GO:0006897 endocytosis(GO:0006897)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
10.8 53.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
10.1 30.3 GO:0033186 CAF-1 complex(GO:0033186)
8.2 24.7 GO:1990423 RZZ complex(GO:1990423)
7.7 23.1 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
6.4 96.5 GO:0042555 MCM complex(GO:0042555)
4.1 20.6 GO:0031523 Myb complex(GO:0031523)
3.8 11.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
3.1 21.7 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
3.1 18.3 GO:0005663 DNA replication factor C complex(GO:0005663)
2.5 7.6 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
2.3 11.6 GO:0035189 Rb-E2F complex(GO:0035189)
1.8 118.7 GO:0005657 replication fork(GO:0005657)
1.4 30.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
1.2 15.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
1.1 31.8 GO:0005721 pericentric heterochromatin(GO:0005721)
1.1 5.4 GO:0044611 nuclear pore inner ring(GO:0044611)
0.8 8.6 GO:0001673 male germ cell nucleus(GO:0001673)
0.7 21.3 GO:0051233 spindle midzone(GO:0051233)
0.6 3.0 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.6 6.1 GO:1904115 axon cytoplasm(GO:1904115)
0.2 8.4 GO:0032590 dendrite membrane(GO:0032590)
0.2 86.2 GO:0005667 transcription factor complex(GO:0005667)
0.2 2.4 GO:0044447 axoneme part(GO:0044447)
0.1 14.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 3.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 5.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.0 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 0.9 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 19.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.7 GO:0000776 kinetochore(GO:0000776)
0.0 24.0 GO:0005730 nucleolus(GO:0005730)
0.0 17.0 GO:0005615 extracellular space(GO:0005615)
0.0 0.3 GO:0015629 actin cytoskeleton(GO:0015629)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
21.4 64.1 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
10.8 53.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
10.5 83.7 GO:0003688 DNA replication origin binding(GO:0003688)
8.6 25.9 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
7.2 21.7 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
5.2 36.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
4.7 14.0 GO:0005534 galactose binding(GO:0005534)
3.8 30.3 GO:0070087 chromo shadow domain binding(GO:0070087)
2.1 12.4 GO:0052630 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
1.7 18.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.6 11.3 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
1.5 7.6 GO:0070883 importin-alpha family protein binding(GO:0061676) pre-miRNA binding(GO:0070883)
0.9 26.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.8 14.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.8 8.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.7 3.6 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.7 36.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.7 5.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.5 5.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.5 11.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 18.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 46.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 22.8 GO:0019955 cytokine binding(GO:0019955)
0.3 17.3 GO:0035064 methylated histone binding(GO:0035064)
0.3 5.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.3 19.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 31.8 GO:0004386 helicase activity(GO:0004386)
0.2 3.0 GO:0042288 MHC class I protein binding(GO:0042288)
0.2 17.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 6.0 GO:0032452 histone demethylase activity(GO:0032452)
0.2 6.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 0.8 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 15.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 52.5 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 12.8 GO:0005096 GTPase activator activity(GO:0005096)