Motif ID: Egr3

Z-value: 0.627


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_70077445-0.094.5e-01Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Showing 1 to 20 of 106 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_119184374 5.789 ENSMUST00000084650.4
Gpr139
G protein-coupled receptor 139
chr9_-_58204310 3.992 ENSMUST00000114144.2
Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr4_+_123183722 3.689 ENSMUST00000152194.1
Hpcal4
hippocalcin-like 4
chr10_+_69534208 3.593 ENSMUST00000182439.1
ENSMUST00000092434.5
ENSMUST00000092432.5
ENSMUST00000092431.5
ENSMUST00000054167.8
ENSMUST00000047061.6
Ank3





ankyrin 3, epithelial





chr10_+_69533803 3.257 ENSMUST00000182155.1
ENSMUST00000183169.1
ENSMUST00000183148.1
Ank3


ankyrin 3, epithelial


chr4_+_123183456 3.095 ENSMUST00000126995.1
Hpcal4
hippocalcin-like 4
chr10_+_69533761 3.015 ENSMUST00000182884.1
Ank3
ankyrin 3, epithelial
chr5_-_138279960 2.867 ENSMUST00000014089.7
ENSMUST00000161827.1
Gpc2

glypican 2 (cerebroglycan)

chr17_-_87282771 2.844 ENSMUST00000161759.1
4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr17_-_87282793 2.832 ENSMUST00000146560.2
4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr2_+_32395896 2.809 ENSMUST00000028162.3
Ptges2
prostaglandin E synthase 2
chr10_-_29144194 2.700 ENSMUST00000070359.2
Gm9996
predicted gene 9996
chr7_+_80860909 2.571 ENSMUST00000132163.1
ENSMUST00000147125.1
Zscan2

zinc finger and SCAN domain containing 2

chr17_-_83631892 2.413 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr17_+_87282880 2.407 ENSMUST00000041110.5
ENSMUST00000125875.1
Ttc7

tetratricopeptide repeat domain 7

chr2_-_65529275 2.354 ENSMUST00000126837.1
Scn3a
sodium channel, voltage-gated, type III, alpha
chr6_-_144209558 2.107 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5

SRY-box containing gene 5

chr6_+_103510874 2.042 ENSMUST00000066905.6
Chl1
cell adhesion molecule with homology to L1CAM
chr8_+_104170513 1.925 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
Bean1



brain expressed, associated with Nedd4, 1



chr10_+_40883819 1.837 ENSMUST00000105509.1
Wasf1
WAS protein family, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 11.5 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 5.8 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.1 4.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.4 3.5 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 2.8 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1 2.6 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.5 2.4 GO:0046684 response to pyrethroid(GO:0046684)
0.1 2.4 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 2.3 GO:0007224 smoothened signaling pathway(GO:0007224)
0.7 2.1 GO:0021852 pyramidal neuron migration(GO:0021852)
0.3 2.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 2.0 GO:0035640 exploration behavior(GO:0035640)
0.6 1.7 GO:0010871 negative regulation of receptor biosynthetic process(GO:0010871)
0.3 1.7 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 1.7 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.3 1.6 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.1 1.5 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.4 1.4 GO:0061626 pharyngeal arch artery morphogenesis(GO:0061626)
0.2 1.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 1.3 GO:0072348 sulfur compound transport(GO:0072348)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 11.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 3.5 GO:0031209 SCAR complex(GO:0031209)
0.0 3.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 1.5 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 1.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 1.4 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 1.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 1.0 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.9 GO:0031430 M band(GO:0031430)
0.1 0.5 GO:1990745 EARP complex(GO:1990745)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.5 GO:0031201 SNARE complex(GO:0031201)
0.1 0.4 GO:0031417 NatC complex(GO:0031417)
0.0 0.4 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.3 GO:0042583 chromaffin granule(GO:0042583)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 12.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 6.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 5.8 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 3.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 2.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.7 2.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 2.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 2.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 2.4 GO:0031402 sodium ion binding(GO:0031402)
0.1 2.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 2.3 GO:0002020 protease binding(GO:0002020)
0.1 1.7 GO:0005522 profilin binding(GO:0005522)
0.1 1.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 1.5 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.1 1.4 GO:0030957 Tat protein binding(GO:0030957)
0.0 1.4 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 1.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 1.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.1 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.1 1.0 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)