Motif ID: En1

Z-value: 0.621


Transcription factors associated with En1:

Gene SymbolEntrez IDGene Name
En1 ENSMUSG00000058665.7 En1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En1mm10_v2_chr1_+_120602405_120602418-0.525.0e-06Click!


Activity profile for motif En1.

activity profile for motif En1


Sorted Z-values histogram for motif En1

Sorted Z-values for motif En1



Network of associatons between targets according to the STRING database.



First level regulatory network of En1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 6.353 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr14_+_67234620 5.137 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr16_-_26989974 3.830 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr19_+_60144682 3.683 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr12_+_109453455 3.643 ENSMUST00000109844.4
ENSMUST00000109842.2
ENSMUST00000109843.1
ENSMUST00000109846.4
ENSMUST00000173539.1
ENSMUST00000109841.2
 Dlk1





delta-like 1 homolog (Drosophila)





chr7_-_30973367 2.936 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr12_+_109452833 2.804 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr6_+_4755327 2.639 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr15_+_102028216 2.542 ENSMUST00000023803.6
 Krt18
keratin 18
chr5_+_90772435 2.498 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr13_+_98354234 2.458 ENSMUST00000105098.3
 Foxd1
forkhead box D1
chr4_-_129227883 2.366 ENSMUST00000106051.1
 C77080
expressed sequence C77080
chr19_+_47014672 2.349 ENSMUST00000037636.3
 Ina
internexin neuronal intermediate filament protein, alpha
chr1_-_87156127 2.344 ENSMUST00000160810.1
 Ecel1
endothelin converting enzyme-like 1
chr1_+_72824482 2.178 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr11_-_77725281 2.098 ENSMUST00000078623.4
 Cryba1
crystallin, beta A1
chr2_+_174450678 2.049 ENSMUST00000016399.5
 Tubb1
tubulin, beta 1 class VI
chr10_-_120899067 2.007 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr5_+_92925400 1.977 ENSMUST00000172706.1
 Shroom3
shroom family member 3
chr16_-_59555752 1.888 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 165 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 5.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.3 5.1 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.7 4.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 3.8 GO:0006270 DNA replication initiation(GO:0006270)
0.4 3.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
1.0 2.9 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.8 2.5 GO:0072076 nephrogenic mesenchyme development(GO:0072076)
0.5 2.5 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.2 2.5 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 2.5 GO:0097284 hepatocyte apoptotic process(GO:0097284)
0.0 2.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 2.5 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 2.4 GO:0003016 respiratory system process(GO:0003016)
0.1 2.2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.3 2.1 GO:2000210 positive regulation of anoikis(GO:2000210)
0.3 2.1 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.4 2.0 GO:0030091 protein repair(GO:0030091)
0.1 2.0 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.6 1.9 GO:0072070 establishment or maintenance of polarity of embryonic epithelium(GO:0016332) loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.2 GO:0005615 extracellular space(GO:0005615)
0.3 4.1 GO:0045180 basal cortex(GO:0045180)
0.3 3.0 GO:0031091 platelet alpha granule(GO:0031091)
0.5 2.9 GO:0061689 tricellular tight junction(GO:0061689)
0.2 2.5 GO:0045095 keratin filament(GO:0045095)
0.3 2.3 GO:0005883 neurofilament(GO:0005883)
0.0 2.1 GO:0043296 apical junction complex(GO:0043296)
0.6 1.8 GO:1990047 spindle matrix(GO:1990047)
0.1 1.7 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.7 GO:0008180 COP9 signalosome(GO:0008180)
0.3 1.6 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 1.6 GO:0042788 polysomal ribosome(GO:0042788)
0.0 1.6 GO:0005811 lipid particle(GO:0005811)
0.2 1.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 1.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 1.4 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.2 GO:0035686 sperm fibrous sheath(GO:0035686)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 4.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.5 3.3 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 2.9 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.8 2.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 2.4 GO:0008301 DNA binding, bending(GO:0008301)
0.0 2.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.3 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.3 2.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 2.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 2.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 2.1 GO:0097110 scaffold protein binding(GO:0097110)
0.3 2.0 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 2.0 GO:0008201 heparin binding(GO:0008201)
0.0 2.0 GO:0030246 carbohydrate binding(GO:0030246)
0.5 1.9 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.1 1.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.6 1.8 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.4 1.8 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 1.7 GO:0017127 cholesterol transporter activity(GO:0017127)