Motif ID: En1
Z-value: 0.621
Transcription factors associated with En1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| En1 | ENSMUSG00000058665.7 | En1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| En1 | mm10_v2_chr1_+_120602405_120602418 | -0.52 | 5.0e-06 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 6.4 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 1.0 | 2.9 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.8 | 2.5 | GO:0072076 | nephrogenic mesenchyme development(GO:0072076) |
| 0.7 | 4.1 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.6 | 1.9 | GO:0072070 | establishment or maintenance of polarity of embryonic epithelium(GO:0016332) loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236) |
| 0.6 | 1.8 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.6 | 1.7 | GO:0030300 | regulation of intestinal cholesterol absorption(GO:0030300) |
| 0.5 | 1.5 | GO:0097278 | complement-dependent cytotoxicity(GO:0097278) |
| 0.5 | 2.5 | GO:0045918 | negative regulation of cytolysis(GO:0045918) |
| 0.4 | 3.3 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.4 | 2.0 | GO:0030091 | protein repair(GO:0030091) |
| 0.4 | 0.7 | GO:0042268 | regulation of cytolysis(GO:0042268) |
| 0.4 | 1.1 | GO:1990046 | positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046) |
| 0.3 | 2.1 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.3 | 5.1 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 0.3 | 1.3 | GO:0070829 | heterochromatin maintenance(GO:0070829) |
| 0.3 | 1.6 | GO:0060467 | negative regulation of fertilization(GO:0060467) |
| 0.3 | 0.8 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.3 | 2.1 | GO:0070474 | positive regulation of uterine smooth muscle contraction(GO:0070474) |
| 0.3 | 1.0 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
| 0.2 | 1.2 | GO:0051852 | antifungal humoral response(GO:0019732) disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873) |
| 0.2 | 1.2 | GO:0019659 | lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
| 0.2 | 0.7 | GO:0002014 | vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014) |
| 0.2 | 0.6 | GO:0030862 | neuroblast division in subventricular zone(GO:0021849) regulation of polarized epithelial cell differentiation(GO:0030860) positive regulation of polarized epithelial cell differentiation(GO:0030862) |
| 0.2 | 0.6 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 0.2 | 0.7 | GO:0060558 | regulation of calcidiol 1-monooxygenase activity(GO:0060558) |
| 0.2 | 0.5 | GO:0072554 | arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) |
| 0.2 | 2.5 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.2 | 1.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.2 | 0.6 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
| 0.2 | 5.3 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.1 | 0.6 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
| 0.1 | 0.4 | GO:1902277 | negative regulation of pancreatic amylase secretion(GO:1902277) |
| 0.1 | 1.1 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.1 | 1.1 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.1 | 2.5 | GO:0097284 | hepatocyte apoptotic process(GO:0097284) |
| 0.1 | 0.5 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.1 | 0.5 | GO:1900110 | negative regulation of histone H3-K9 dimethylation(GO:1900110) |
| 0.1 | 0.9 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
| 0.1 | 0.5 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.1 | 1.7 | GO:0050849 | negative regulation of calcium-mediated signaling(GO:0050849) |
| 0.1 | 0.6 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 3.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 2.2 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.1 | 1.1 | GO:1903975 | regulation of glial cell migration(GO:1903975) |
| 0.1 | 0.8 | GO:1900194 | negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194) |
| 0.1 | 0.8 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.1 | 0.4 | GO:0010920 | negative regulation of inositol phosphate biosynthetic process(GO:0010920) |
| 0.1 | 0.5 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
| 0.1 | 0.3 | GO:0048162 | preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162) |
| 0.1 | 0.4 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 0.1 | 0.9 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.1 | 1.9 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.1 | 1.5 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.1 | 0.7 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.1 | 0.5 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.1 | 0.6 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.1 | 0.5 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
| 0.1 | 0.8 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.1 | 0.4 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.1 | 0.4 | GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255) |
| 0.1 | 0.2 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.1 | 0.6 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.1 | 0.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 0.2 | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response(GO:1903896) |
| 0.1 | 0.6 | GO:0043615 | astrocyte cell migration(GO:0043615) |
| 0.1 | 2.4 | GO:0003016 | respiratory system process(GO:0003016) |
| 0.1 | 2.0 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 0.1 | 0.6 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.1 | 0.2 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.1 | 0.6 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.1 | 0.4 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.1 | 0.2 | GO:1901524 | regulation of macromitophagy(GO:1901524) negative regulation of macromitophagy(GO:1901525) |
| 0.1 | 0.7 | GO:0030238 | male sex determination(GO:0030238) |
| 0.1 | 0.7 | GO:0002098 | tRNA wobble uridine modification(GO:0002098) |
| 0.1 | 0.1 | GO:0072053 | renal inner medulla development(GO:0072053) renal outer medulla development(GO:0072054) |
| 0.1 | 0.5 | GO:0019348 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) dolichol metabolic process(GO:0019348) |
| 0.1 | 0.9 | GO:0030574 | collagen catabolic process(GO:0030574) negative regulation of phagocytosis(GO:0050765) |
| 0.1 | 0.7 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479) |
| 0.1 | 0.4 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
| 0.1 | 0.6 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.1 | 0.3 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
| 0.1 | 0.6 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.0 | 0.8 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.0 | 0.3 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
| 0.0 | 0.3 | GO:0001842 | neural fold formation(GO:0001842) |
| 0.0 | 0.8 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.0 | 0.8 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.0 | 0.8 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
| 0.0 | 0.4 | GO:0044351 | macropinocytosis(GO:0044351) |
| 0.0 | 0.5 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.0 | 0.3 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.0 | 0.3 | GO:0032782 | bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360) |
| 0.0 | 0.1 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.0 | 0.5 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.0 | 0.6 | GO:0010388 | cullin deneddylation(GO:0010388) |
| 0.0 | 0.7 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.5 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.0 | 0.6 | GO:0097688 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.0 | 2.5 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
| 0.0 | 0.2 | GO:0031442 | positive regulation of mRNA 3'-end processing(GO:0031442) |
| 0.0 | 0.2 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 0.0 | 2.5 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.0 | 0.2 | GO:0048023 | positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378) |
| 0.0 | 0.1 | GO:0010694 | positive regulation of alkaline phosphatase activity(GO:0010694) |
| 0.0 | 1.0 | GO:0001782 | B cell homeostasis(GO:0001782) |
| 0.0 | 0.5 | GO:0000183 | chromatin silencing at rDNA(GO:0000183) |
| 0.0 | 0.3 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.0 | 0.1 | GO:0014042 | positive regulation of mitochondrial fusion(GO:0010636) positive regulation of neuron maturation(GO:0014042) |
| 0.0 | 0.6 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 1.6 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.0 | 1.8 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 0.0 | 0.4 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.0 | 1.2 | GO:0030901 | midbrain development(GO:0030901) |
| 0.0 | 0.3 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.0 | 0.5 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
| 0.0 | 0.3 | GO:0044539 | long-chain fatty acid import(GO:0044539) |
| 0.0 | 0.1 | GO:0008612 | peptidyl-lysine modification to peptidyl-hypusine(GO:0008612) |
| 0.0 | 0.1 | GO:0036015 | response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016) |
| 0.0 | 0.4 | GO:0007263 | nitric oxide mediated signal transduction(GO:0007263) |
| 0.0 | 0.6 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.5 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.0 | GO:0002097 | tRNA wobble base modification(GO:0002097) |
| 0.0 | 0.4 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.0 | 0.3 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.0 | 0.1 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 0.7 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 0.4 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 0.2 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.0 | 1.4 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.0 | 0.4 | GO:0001504 | neurotransmitter uptake(GO:0001504) |
| 0.0 | 1.8 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.0 | 0.2 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.0 | 0.3 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.0 | 0.2 | GO:0033683 | nucleotide-excision repair, DNA incision(GO:0033683) |
| 0.0 | 0.9 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
| 0.0 | 0.4 | GO:0007099 | centriole replication(GO:0007099) |
| 0.0 | 0.6 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
| 0.0 | 0.9 | GO:0016574 | histone ubiquitination(GO:0016574) |
| 0.0 | 1.3 | GO:0006405 | RNA export from nucleus(GO:0006405) |
| 0.0 | 0.6 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 0.0 | 0.1 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.0 | 0.7 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.1 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.0 | 0.6 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.0 | 0.9 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 0.3 | GO:0006303 | double-strand break repair via nonhomologous end joining(GO:0006303) |
| 0.0 | 0.5 | GO:0051452 | intracellular pH reduction(GO:0051452) |
| 0.0 | 0.2 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.0 | 1.0 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 0.3 | GO:0014829 | vascular smooth muscle contraction(GO:0014829) |
| 0.0 | 0.2 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
| 0.0 | 0.3 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 0.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.1 | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway(GO:0031547) sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.6 | GO:1902600 | hydrogen ion transmembrane transport(GO:1902600) |
| 0.0 | 0.1 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 0.0 | 0.3 | GO:0006541 | glutamine metabolic process(GO:0006541) |
| 0.0 | 0.7 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.1 | GO:0006677 | glycosylceramide metabolic process(GO:0006677) |
| 0.0 | 0.1 | GO:0046015 | regulation of transcription by glucose(GO:0046015) |
| 0.0 | 0.3 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.0 | 0.4 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.0 | 0.1 | GO:0051790 | short-chain fatty acid biosynthetic process(GO:0051790) |
| 0.0 | 0.1 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.8 | GO:1990047 | spindle matrix(GO:1990047) |
| 0.5 | 2.9 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.3 | 1.6 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.3 | 4.1 | GO:0045180 | basal cortex(GO:0045180) |
| 0.3 | 3.0 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.3 | 2.3 | GO:0005883 | neurofilament(GO:0005883) |
| 0.2 | 1.5 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.2 | 2.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 0.5 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
| 0.1 | 1.4 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 0.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 0.5 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.1 | 1.6 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 0.7 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.1 | 0.5 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.1 | 0.5 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.1 | 0.8 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.1 | 0.7 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.1 | 0.5 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 1.2 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 0.3 | GO:0032021 | NELF complex(GO:0032021) |
| 0.1 | 0.3 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.1 | 0.2 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 1.4 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.1 | 1.3 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 0.7 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.1 | 1.7 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.1 | 0.4 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.1 | 1.3 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 0.3 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.1 | 0.3 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
| 0.1 | 0.4 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.1 | 0.6 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.1 | 1.2 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.1 | 0.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.2 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.0 | 1.0 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 0.5 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.0 | 0.2 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 0.3 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 0.5 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 1.7 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.2 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 0.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 0.2 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 0.6 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 0.4 | GO:0032797 | SMN complex(GO:0032797) |
| 0.0 | 0.5 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.5 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.0 | 0.3 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 0.3 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 0.2 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 0.3 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 1.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.3 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
| 0.0 | 0.4 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.7 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.3 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 0.2 | GO:0000243 | commitment complex(GO:0000243) |
| 0.0 | 0.2 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.0 | 0.5 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 1.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.8 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.2 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.3 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
| 0.0 | 16.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 0.1 | GO:0044308 | axonal spine(GO:0044308) |
| 0.0 | 0.2 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 0.2 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.6 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.1 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.0 | 0.1 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500) |
| 0.0 | 2.1 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.0 | 0.2 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.6 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 0.9 | GO:0031968 | mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968) |
| 0.0 | 0.2 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 0.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.2 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 0.4 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.3 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.3 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 0.1 | GO:0000421 | autophagosome membrane(GO:0000421) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.5 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.6 | 1.8 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.5 | 3.3 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.5 | 1.9 | GO:1902379 | chemoattractant activity involved in axon guidance(GO:1902379) |
| 0.4 | 1.1 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.4 | 1.1 | GO:1901611 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
| 0.4 | 1.8 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.4 | 1.1 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
| 0.4 | 1.1 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.3 | 1.2 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.3 | 2.0 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
| 0.3 | 2.2 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.3 | 1.5 | GO:0002135 | CTP binding(GO:0002135) |
| 0.2 | 2.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 0.7 | GO:0030620 | U2 snRNA binding(GO:0030620) |
| 0.2 | 1.2 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.2 | 0.6 | GO:0034952 | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity(GO:0008694) 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity(GO:0018791) bis(4-chlorophenyl)acetate decarboxylase activity(GO:0018792) 3,5-dibromo-4-hydroxybenzoate decarboxylase activity(GO:0018793) 2-hydroxyisobutyrate decarboxylase activity(GO:0018794) 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity(GO:0018795) 2-hydroxyisophthalate decarboxylase activity(GO:0034524) dimethylmalonate decarboxylase activity(GO:0034782) 2,4,4-trimethyl-3-oxopentanoate decarboxylase activity(GO:0034853) 4,4-dimethyl-3-oxopentanoate decarboxylase activity(GO:0034854) 2,3,6-trihydroxyisonicotinate decarboxylase activity(GO:0034879) phenanthrene-4,5-dicarboxylate decarboxylase activity(GO:0034923) pyrrole-2-carboxylate decarboxylase activity(GO:0034941) terephthalate decarboxylase activity(GO:0034947) malonate semialdehyde decarboxylase activity(GO:0034952) 5-amino-4-imidazole carboxylate lyase activity(GO:0043727) 2-keto-4-methylthiobutyrate aminotransferase activity(GO:0043728) 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity(GO:0051997) |
| 0.2 | 0.8 | GO:0050347 | trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347) |
| 0.2 | 2.4 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.2 | 1.1 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.2 | 0.7 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 0.2 | 2.9 | GO:0030228 | lipoprotein particle receptor activity(GO:0030228) |
| 0.2 | 0.5 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.2 | 1.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 0.4 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.1 | 0.6 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 0.5 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.1 | 1.7 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.1 | 1.2 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.1 | 0.5 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.1 | 0.5 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 0.1 | 0.3 | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
| 0.1 | 0.3 | GO:0042923 | neuropeptide binding(GO:0042923) |
| 0.1 | 0.5 | GO:0008761 | UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) |
| 0.1 | 0.5 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.1 | 0.5 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.1 | 1.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 0.9 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.1 | 0.4 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.1 | 2.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 0.3 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
| 0.1 | 0.7 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668) |
| 0.1 | 0.6 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.1 | 0.3 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.1 | 1.4 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.1 | 0.3 | GO:0003883 | CTP synthase activity(GO:0003883) |
| 0.1 | 0.4 | GO:0034235 | GPI anchor binding(GO:0034235) |
| 0.1 | 0.5 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 0.6 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.1 | 0.4 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.1 | 0.8 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.1 | 0.8 | GO:0034951 | pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011) |
| 0.1 | 1.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 0.7 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 0.2 | GO:0032564 | dATP binding(GO:0032564) |
| 0.1 | 1.4 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.1 | 1.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 1.3 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 0.2 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.1 | 0.2 | GO:0004307 | ethanolaminephosphotransferase activity(GO:0004307) |
| 0.1 | 0.3 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 0.5 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.0 | 0.8 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.0 | 0.2 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 0.5 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.0 | 0.7 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.3 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 0.0 | 0.4 | GO:0004630 | phospholipase D activity(GO:0004630) |
| 0.0 | 4.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.9 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.9 | GO:0008308 | voltage-gated anion channel activity(GO:0008308) |
| 0.0 | 0.4 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.5 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.3 | GO:0008193 | tRNA guanylyltransferase activity(GO:0008193) |
| 0.0 | 0.5 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 0.1 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.0 | 2.1 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 0.4 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.3 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.0 | 0.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 2.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.9 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.7 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 1.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.1 | GO:0003945 | N-acetyllactosamine synthase activity(GO:0003945) |
| 0.0 | 9.5 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 0.4 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172) |
| 0.0 | 2.3 | GO:0101005 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 0.4 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.0 | 0.5 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 0.3 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.0 | 0.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 1.0 | GO:0008528 | G-protein coupled peptide receptor activity(GO:0008528) |
| 0.0 | 0.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 0.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.1 | GO:0008312 | 7S RNA binding(GO:0008312) |
| 0.0 | 1.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.3 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 1.1 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 2.0 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 0.5 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.1 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.0 | 0.3 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 0.5 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.0 | 0.2 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.5 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 0.6 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 2.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 0.1 | GO:0005451 | monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.4 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.0 | 0.4 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 1.2 | GO:0043021 | ribonucleoprotein complex binding(GO:0043021) |
