Motif ID: En2

Z-value: 0.504


Transcription factors associated with En2:

Gene SymbolEntrez IDGene Name
En2 ENSMUSG00000039095.7 En2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En2mm10_v2_chr5_+_28165690_28165717-0.085.0e-01Click!


Activity profile for motif En2.

activity profile for motif En2


Sorted Z-values histogram for motif En2

Sorted Z-values for motif En2



Network of associatons between targets according to the STRING database.



First level regulatory network of En2

PNG image of the network

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Top targets:


Showing 1 to 20 of 161 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_8948608 3.279 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr5_-_62766153 3.174 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_25372315 2.898 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
Sapcd2


suppressor APC domain containing 2


chr13_+_23574381 2.756 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chrX_-_60893430 2.700 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr14_-_67715585 2.611 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
Cdca2


cell division cycle associated 2


chr4_+_109978004 2.471 ENSMUST00000061187.3
Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr5_-_53707532 2.146 ENSMUST00000031093.3
Cckar
cholecystokinin A receptor
chr10_+_73821857 2.064 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
Pcdh15



















protocadherin 15



















chr5_-_77115145 1.930 ENSMUST00000081964.5
Hopx
HOP homeobox
chr5_+_33658123 1.842 ENSMUST00000074849.6
ENSMUST00000079534.4
Tacc3

transforming, acidic coiled-coil containing protein 3

chr2_+_20737306 1.839 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr3_-_27153861 1.836 ENSMUST00000108300.1
ENSMUST00000108298.2
Ect2

ect2 oncogene

chr13_-_47106176 1.802 ENSMUST00000021807.6
ENSMUST00000135278.1
Dek

DEK oncogene (DNA binding)

chr5_+_139543889 1.746 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr3_-_27153844 1.680 ENSMUST00000176242.2
ENSMUST00000176780.1
Ect2

ect2 oncogene

chr13_+_23544052 1.670 ENSMUST00000075558.2
Hist1h3f
histone cluster 1, H3f
chr18_-_80986578 1.665 ENSMUST00000057950.7
Sall3
sal-like 3 (Drosophila)
chr5_+_33658567 1.526 ENSMUST00000114426.3
Tacc3
transforming, acidic coiled-coil containing protein 3
chr13_+_21717626 1.522 ENSMUST00000091754.2
Hist1h3h
histone cluster 1, H3h

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.7 GO:0030953 astral microtubule organization(GO:0030953)
0.1 3.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 3.5 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 2.6 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
0.0 2.6 GO:0006342 chromatin silencing(GO:0006342)
0.2 2.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 2.5 GO:0007530 sex determination(GO:0007530)
0.7 2.1 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.2 2.1 GO:0050957 equilibrioception(GO:0050957)
0.1 2.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.3 1.9 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.5 1.8 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.4 1.8 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 1.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 1.7 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 1.7 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.5 GO:0019985 translesion synthesis(GO:0019985)
0.1 1.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.3 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 1.3 GO:0034508 centromere complex assembly(GO:0034508)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 GO:0070469 respiratory chain(GO:0070469)
0.7 3.5 GO:0097149 centralspindlin complex(GO:0097149)
0.1 3.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 2.3 GO:0043292 contractile fiber(GO:0043292)
0.1 2.1 GO:0032420 stereocilium(GO:0032420)
0.1 1.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.7 GO:0000786 nucleosome(GO:0000786)
0.0 1.5 GO:0043195 terminal bouton(GO:0043195)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 1.1 GO:0044301 climbing fiber(GO:0044301)
0.1 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 0.9 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.1 0.7 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.7 GO:0005871 kinesin complex(GO:0005871)
0.1 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.4 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.3 GO:0071437 invadopodium(GO:0071437)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 GO:0042393 histone binding(GO:0042393)
0.1 4.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 3.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.8 GO:0008483 transaminase activity(GO:0008483)
0.0 1.3 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 1.3 GO:0003682 chromatin binding(GO:0003682)
0.1 1.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 1.2 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 1.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.1 GO:0001968 fibronectin binding(GO:0001968)
0.0 1.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 0.9 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.7 GO:0043495 protein anchor(GO:0043495)
0.0 0.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.7 GO:0003777 microtubule motor activity(GO:0003777)
0.1 0.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)