Motif ID: En2
Z-value: 0.504
Transcription factors associated with En2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| En2 | ENSMUSG00000039095.7 | En2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| En2 | mm10_v2_chr5_+_28165690_28165717 | -0.08 | 5.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.1 | GO:0090274 | positive regulation of somatostatin secretion(GO:0090274) |
| 0.5 | 1.8 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.4 | 1.1 | GO:0061743 | motor learning(GO:0061743) |
| 0.4 | 1.8 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.3 | 1.0 | GO:0060023 | soft palate development(GO:0060023) |
| 0.3 | 1.9 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
| 0.3 | 4.7 | GO:0030953 | astral microtubule organization(GO:0030953) |
| 0.2 | 2.1 | GO:0050957 | equilibrioception(GO:0050957) |
| 0.2 | 0.9 | GO:0072592 | regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592) |
| 0.2 | 1.7 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.2 | 3.5 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.2 | 0.7 | GO:0032512 | regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.2 | 2.5 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.2 | 1.1 | GO:0071361 | cellular response to ethanol(GO:0071361) |
| 0.1 | 0.4 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.1 | 2.5 | GO:0007530 | sex determination(GO:0007530) |
| 0.1 | 0.5 | GO:0090324 | negative regulation of oxidative phosphorylation(GO:0090324) |
| 0.1 | 1.5 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.1 | 3.9 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.1 | 1.2 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.1 | 0.7 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 1.7 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
| 0.1 | 0.3 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
| 0.1 | 1.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 0.3 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.1 | 0.4 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.1 | 0.6 | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway(GO:0031547) |
| 0.1 | 2.0 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.1 | 0.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.1 | 0.3 | GO:0046689 | response to mercury ion(GO:0046689) |
| 0.1 | 1.3 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
| 0.1 | 0.4 | GO:0006551 | leucine metabolic process(GO:0006551) |
| 0.1 | 1.0 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.1 | 2.6 | GO:0035307 | positive regulation of protein dephosphorylation(GO:0035307) |
| 0.0 | 0.5 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 1.3 | GO:0034508 | centromere complex assembly(GO:0034508) |
| 0.0 | 0.7 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.0 | 0.4 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) |
| 0.0 | 0.1 | GO:0002578 | negative regulation of antigen processing and presentation(GO:0002578) |
| 0.0 | 0.2 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.0 | 0.3 | GO:0048199 | vesicle targeting, to, from or within Golgi(GO:0048199) |
| 0.0 | 2.6 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 1.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 0.5 | GO:0033194 | response to hydroperoxide(GO:0033194) |
| 0.0 | 0.3 | GO:0099625 | regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) ventricular cardiac muscle cell membrane repolarization(GO:0099625) |
| 0.0 | 0.6 | GO:0022900 | electron transport chain(GO:0022900) |
| 0.0 | 0.6 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.2 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.0 | 0.3 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.0 | 0.6 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 0.6 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.0 | 0.2 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.0 | 0.3 | GO:0009409 | response to cold(GO:0009409) |
| 0.0 | 0.1 | GO:0002361 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.5 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.2 | 1.1 | GO:0044301 | climbing fiber(GO:0044301) |
| 0.2 | 0.9 | GO:0071438 | NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438) |
| 0.1 | 0.3 | GO:0071437 | invadopodium(GO:0071437) |
| 0.1 | 3.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 0.3 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.1 | 1.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 0.7 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 1.0 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 1.1 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 4.3 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 0.6 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 2.1 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 1.7 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.4 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 0.5 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.1 | GO:1990357 | terminal web(GO:1990357) |
| 0.0 | 0.3 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
| 0.0 | 0.3 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 1.2 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.6 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 0.1 | GO:0070688 | MLL5-L complex(GO:0070688) |
| 0.0 | 1.5 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.3 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 2.3 | GO:0043292 | contractile fiber(GO:0043292) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.1 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.3 | 0.9 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
| 0.1 | 1.2 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.1 | 3.0 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 0.4 | GO:0071532 | ornithine decarboxylase inhibitor activity(GO:0008073) ankyrin repeat binding(GO:0071532) |
| 0.1 | 3.0 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 4.1 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 0.7 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 1.8 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.1 | 0.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 0.3 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.1 | 1.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 1.2 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.3 | GO:0015265 | urea channel activity(GO:0015265) |
| 0.0 | 0.3 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.0 | 1.1 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 3.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.1 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.0 | 1.3 | GO:0008528 | G-protein coupled peptide receptor activity(GO:0008528) |
| 0.0 | 4.7 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.3 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 0.7 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 0.2 | GO:0015180 | L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858) |
| 0.0 | 0.4 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.0 | 0.4 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.0 | 0.1 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.0 | 0.5 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.3 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.0 | 0.1 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.0 | 0.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 1.3 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 0.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
