Motif ID: Ep300
Z-value: 0.559
Transcription factors associated with Ep300:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Ep300 | ENSMUSG00000055024.6 | Ep300 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ep300 | mm10_v2_chr15_+_81586206_81586250 | -0.10 | 3.9e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 5.6 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
| 1.1 | 3.4 | GO:1900736 | regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736) |
| 0.6 | 2.2 | GO:0032289 | central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912) |
| 0.4 | 1.8 | GO:0010637 | negative regulation of mitochondrial fusion(GO:0010637) |
| 0.4 | 2.9 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.3 | 2.3 | GO:1904217 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.3 | 1.6 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.3 | 2.0 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.3 | 1.1 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.3 | 2.5 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 0.2 | 4.7 | GO:0014051 | gamma-aminobutyric acid secretion(GO:0014051) |
| 0.2 | 1.4 | GO:0046880 | regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884) |
| 0.2 | 1.9 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.2 | 3.2 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.2 | 2.1 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.2 | 0.8 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
| 0.2 | 2.2 | GO:0071257 | cellular response to electrical stimulus(GO:0071257) |
| 0.2 | 0.7 | GO:0046898 | response to cycloheximide(GO:0046898) |
| 0.2 | 1.2 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.2 | 0.8 | GO:0051189 | Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189) |
| 0.1 | 1.6 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
| 0.1 | 0.6 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.1 | 1.8 | GO:0035635 | entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535) |
| 0.1 | 2.4 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.1 | 0.9 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.1 | 0.4 | GO:0046122 | purine deoxyribonucleoside metabolic process(GO:0046122) |
| 0.1 | 0.5 | GO:0051866 | general adaptation syndrome(GO:0051866) |
| 0.1 | 0.6 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) |
| 0.1 | 0.6 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
| 0.1 | 1.2 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.1 | 1.7 | GO:2000821 | regulation of grooming behavior(GO:2000821) |
| 0.1 | 0.7 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.1 | 2.4 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.1 | 0.6 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.1 | 0.7 | GO:0001955 | blood vessel maturation(GO:0001955) |
| 0.1 | 0.6 | GO:1904263 | positive regulation of TORC1 signaling(GO:1904263) |
| 0.1 | 0.4 | GO:0010936 | negative regulation of macrophage cytokine production(GO:0010936) |
| 0.1 | 1.1 | GO:1903963 | arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963) |
| 0.1 | 2.2 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.1 | 0.4 | GO:2000298 | regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298) |
| 0.1 | 0.2 | GO:0015960 | diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966) |
| 0.1 | 3.1 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.1 | 0.3 | GO:0071105 | response to interleukin-11(GO:0071105) osteoclast fusion(GO:0072675) |
| 0.1 | 0.3 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.1 | 0.5 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.1 | 0.4 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.1 | 0.5 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.1 | 0.3 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.1 | 0.3 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
| 0.1 | 0.2 | GO:1904154 | trimming of terminal mannose on B branch(GO:0036509) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
| 0.1 | 0.3 | GO:0072015 | glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310) |
| 0.1 | 0.8 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.0 | 0.5 | GO:1902969 | mitotic DNA replication(GO:1902969) |
| 0.0 | 0.6 | GO:0060395 | SMAD protein signal transduction(GO:0060395) |
| 0.0 | 0.5 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) |
| 0.0 | 0.3 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.0 | 7.8 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
| 0.0 | 6.3 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 0.2 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.0 | 1.0 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.0 | 1.1 | GO:0051926 | negative regulation of calcium ion transport(GO:0051926) |
| 0.0 | 1.5 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.0 | 0.3 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.0 | 0.5 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.0 | 1.2 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.0 | 0.5 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.0 | 0.3 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.0 | 0.2 | GO:0060510 | Type II pneumocyte differentiation(GO:0060510) |
| 0.0 | 0.8 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.0 | 0.8 | GO:0006110 | regulation of glycolytic process(GO:0006110) |
| 0.0 | 1.0 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 0.0 | 0.4 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.0 | 0.8 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.4 | GO:0048557 | embryonic digestive tract morphogenesis(GO:0048557) |
| 0.0 | 1.2 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 0.3 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.1 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 0.0 | 0.6 | GO:0019319 | hexose biosynthetic process(GO:0019319) |
| 0.0 | 0.3 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 0.4 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
| 0.0 | 0.9 | GO:0001676 | long-chain fatty acid metabolic process(GO:0001676) |
| 0.0 | 0.9 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 0.7 | GO:1904892 | regulation of JAK-STAT cascade(GO:0046425) regulation of STAT cascade(GO:1904892) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.4 | GO:0043512 | inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512) |
| 0.2 | 1.2 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.2 | 2.5 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.2 | 3.1 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.2 | 2.3 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.2 | 1.8 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.2 | 0.5 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.1 | 1.6 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.1 | 0.6 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.1 | 5.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 0.4 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.1 | 0.7 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.1 | 8.4 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 2.2 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 1.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 1.1 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 0.7 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.1 | 0.3 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.1 | 2.1 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 0.8 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 2.5 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 6.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.6 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 1.4 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 1.0 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 0.5 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.6 | GO:0005675 | holo TFIIH complex(GO:0005675) |
| 0.0 | 1.2 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.2 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.0 | 0.2 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 0.8 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.3 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.0 | 1.8 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 3.4 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 0.3 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.1 | GO:0097361 | CIA complex(GO:0097361) |
| 0.0 | 0.9 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.1 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 0.5 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.3 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.2 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 1.4 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 1.8 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.4 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 1.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 5.6 | GO:0031752 | D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752) |
| 1.1 | 1.1 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.5 | 2.4 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.4 | 2.1 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) |
| 0.3 | 2.5 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
| 0.3 | 0.9 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.3 | 1.1 | GO:0008061 | chitin binding(GO:0008061) |
| 0.2 | 0.6 | GO:0050656 | 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
| 0.2 | 3.8 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.2 | 0.6 | GO:0008521 | acetyl-CoA transporter activity(GO:0008521) |
| 0.2 | 5.5 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.2 | 1.2 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 1.2 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.2 | 2.9 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.2 | 0.6 | GO:0004368 | glycerol-3-phosphate dehydrogenase activity(GO:0004368) |
| 0.2 | 1.1 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.2 | 2.3 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 0.6 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.1 | 0.6 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 1.3 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.1 | 2.4 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 0.7 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 0.6 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.1 | 1.1 | GO:0042923 | neuropeptide binding(GO:0042923) |
| 0.1 | 0.4 | GO:0019136 | deoxynucleoside kinase activity(GO:0019136) |
| 0.1 | 0.7 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 3.3 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 1.2 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 0.8 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.1 | 0.8 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.1 | 0.9 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.1 | 0.8 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
| 0.1 | 1.6 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.1 | 1.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 0.5 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 0.4 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 2.2 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 0.4 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.0 | 1.7 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.2 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.0 | 1.0 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.7 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.0 | 0.3 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.3 | GO:0051718 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718) |
| 0.0 | 1.9 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.5 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 1.5 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 0.5 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 2.2 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.7 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.6 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 2.2 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 1.3 | GO:0004812 | aminoacyl-tRNA ligase activity(GO:0004812) |
| 0.0 | 0.5 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 1.0 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 3.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 1.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.3 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 0.2 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 2.0 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 0.1 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668) |
| 0.0 | 0.7 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.0 | 0.5 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 0.1 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.0 | 0.5 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 1.7 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 0.2 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 1.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.2 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 0.3 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.2 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.8 | GO:0032947 | protein complex scaffold(GO:0032947) |
