Motif ID: Epas1_Bcl3

Z-value: 1.872

Transcription factors associated with Epas1_Bcl3:

Gene SymbolEntrez IDGene Name
Bcl3 ENSMUSG00000053175.10 Bcl3
Epas1 ENSMUSG00000024140.9 Epas1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Epas1mm10_v2_chr17_+_86753900_867539140.326.7e-03Click!


Activity profile for motif Epas1_Bcl3.

activity profile for motif Epas1_Bcl3


Sorted Z-values histogram for motif Epas1_Bcl3

Sorted Z-values for motif Epas1_Bcl3



Network of associatons between targets according to the STRING database.



First level regulatory network of Epas1_Bcl3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_48932368 27.360 ENSMUST00000046254.2
 Lrfn2
leucine rich repeat and fibronectin type III domain containing 2
chr3_-_80802789 25.595 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr14_-_60177482 25.358 ENSMUST00000140924.1
 Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr4_+_48045144 22.329 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr2_-_113217051 21.706 ENSMUST00000080673.5
 Ryr3
ryanodine receptor 3
chr1_+_75507077 20.780 ENSMUST00000037330.4
 Inha
inhibin alpha
chr4_-_20778527 20.494 ENSMUST00000119374.1
 Nkain3
Na+/K+ transporting ATPase interacting 3
chr19_+_23758819 19.931 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr2_+_169632996 19.916 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr12_-_14152038 19.535 ENSMUST00000020926.6
 Fam84a
family with sequence similarity 84, member A
chr12_+_61523889 19.437 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr9_-_29963112 19.369 ENSMUST00000075069.4
 Ntm
neurotrimin
chr19_+_8664005 19.083 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr18_-_25753852 18.946 ENSMUST00000025117.6
ENSMUST00000115816.2
 Celf4

CUGBP, Elav-like family member 4

chr17_+_86167777 18.882 ENSMUST00000097275.2
 Prkce
protein kinase C, epsilon
chr9_-_40346290 17.494 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr4_+_123183722 16.946 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr8_-_48555846 16.746 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr12_-_67221221 15.521 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr7_-_27446599 15.163 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.8 40.3 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.3 28.2 GO:0002028 regulation of sodium ion transport(GO:0002028)
4.6 27.7 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
1.5 26.8 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
1.7 25.1 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
7.4 22.3 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
1.0 21.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
2.6 20.5 GO:0097264 self proteolysis(GO:0097264)
0.3 19.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
3.2 19.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.7 19.2 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
4.7 18.9 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
1.7 18.9 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.1 16.8 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.7 16.2 GO:0016082 synaptic vesicle priming(GO:0016082)
2.2 15.5 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393) follicle-stimulating hormone signaling pathway(GO:0042699)
2.5 15.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 15.1 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
1.5 13.9 GO:0098907 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
0.3 13.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 62.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 47.1 GO:0016021 integral component of membrane(GO:0016021)
2.2 44.7 GO:0032279 asymmetric synapse(GO:0032279)
0.1 35.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 32.7 GO:0043197 dendritic spine(GO:0043197)
0.2 31.4 GO:0045211 postsynaptic membrane(GO:0045211)
9.2 27.7 GO:0043512 inhibin A complex(GO:0043512)
0.3 22.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
4.3 21.7 GO:0030314 junctional membrane complex(GO:0030314)
2.8 19.4 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.2 18.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 15.8 GO:0043025 neuronal cell body(GO:0043025)
1.0 15.5 GO:0031143 pseudopodium(GO:0031143)
2.5 15.2 GO:0008091 spectrin(GO:0008091)
0.1 14.7 GO:0000139 Golgi membrane(GO:0000139)
0.5 14.2 GO:0033268 node of Ranvier(GO:0033268)
0.4 14.2 GO:0097440 apical dendrite(GO:0097440)
0.7 13.9 GO:0031430 M band(GO:0031430)
0.2 12.6 GO:0042734 presynaptic membrane(GO:0042734)
3.0 11.9 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 40.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.6 35.0 GO:0030507 spectrin binding(GO:0030507)
0.6 32.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
3.1 27.7 GO:0034711 inhibin binding(GO:0034711)
4.1 24.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.7 23.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.5 21.9 GO:0005246 calcium channel regulator activity(GO:0005246)
7.2 21.7 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
3.2 19.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.7 19.0 GO:0005272 sodium channel activity(GO:0005272)
0.6 19.0 GO:0030552 cAMP binding(GO:0030552)
4.7 18.9 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.4 18.4 GO:0015459 potassium channel regulator activity(GO:0015459)
1.1 18.2 GO:0001223 transcription coactivator binding(GO:0001223)
5.2 15.5 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 14.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
2.2 13.5 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
2.6 13.2 GO:0055100 adiponectin binding(GO:0055100)
0.7 13.2 GO:0008188 neuropeptide receptor activity(GO:0008188)
2.1 12.9 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)