Motif ID: Ets2

Z-value: 1.151


Transcription factors associated with Ets2:

Gene SymbolEntrez IDGene Name
Ets2 ENSMUSG00000022895.8 Ets2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ets2mm10_v2_chr16_+_95702044_957020940.381.1e-03Click!


Activity profile for motif Ets2.

activity profile for motif Ets2


Sorted Z-values histogram for motif Ets2

Sorted Z-values for motif Ets2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ets2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 18.010 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr17_+_3397189 14.598 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr6_+_5725812 14.596 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr15_-_66969616 12.737 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr9_-_29411736 10.814 ENSMUST00000115236.1
 Ntm
neurotrimin
chr7_-_4546567 10.690 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr2_-_156392829 10.624 ENSMUST00000088578.2
 2900097C17Rik
RIKEN cDNA 2900097C17 gene
chr13_-_59823072 10.302 ENSMUST00000071703.4
 Zcchc6
zinc finger, CCHC domain containing 6
chr1_-_56969864 9.827 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 9.787 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr3_-_80802789 9.014 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr4_+_128058962 8.388 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr3_+_82358056 7.931 ENSMUST00000091014.4
 Map9
microtubule-associated protein 9
chr2_-_5714490 7.554 ENSMUST00000044009.7
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chrX_+_163908982 7.499 ENSMUST00000069041.8
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr5_-_44799643 7.377 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr11_+_70647258 7.163 ENSMUST00000037534.7
 Rnf167
ring finger protein 167
chr5_+_117133567 6.785 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
 Taok3


TAO kinase 3


chr7_+_44850393 6.628 ENSMUST00000136232.1
 Akt1s1
AKT1 substrate 1 (proline-rich)
chr13_+_109632760 6.367 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 190 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 38.1 GO:0047496 vesicle transport along microtubule(GO:0047496)
0.2 38.0 GO:0007266 Rho protein signal transduction(GO:0007266)
0.5 22.2 GO:0036465 synaptic vesicle recycling(GO:0036465)
1.2 19.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.5 13.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.4 13.2 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
1.3 12.7 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.4 11.2 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.9 9.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.5 9.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 8.3 GO:0030010 establishment of cell polarity(GO:0030010)
0.1 8.2 GO:0060976 coronary vasculature development(GO:0060976)
0.2 7.9 GO:1902850 mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.1 7.9 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 7.7 GO:0043087 regulation of GTPase activity(GO:0043087)
1.1 7.6 GO:0060267 positive regulation of respiratory burst(GO:0060267)
2.4 7.2 GO:0019085 early viral transcription(GO:0019085)
0.4 6.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.4 6.7 GO:0060363 cranial suture morphogenesis(GO:0060363)
1.6 6.6 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 29.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 19.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 17.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.4 15.7 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 13.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.6 13.6 GO:0031430 M band(GO:0031430)
0.4 12.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 12.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 11.9 GO:0000118 histone deacetylase complex(GO:0000118)
1.2 11.6 GO:0071439 clathrin complex(GO:0071439)
1.2 11.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 10.8 GO:0031225 anchored component of membrane(GO:0031225)
0.7 10.7 GO:0031045 dense core granule(GO:0031045)
0.4 9.0 GO:0032279 asymmetric synapse(GO:0032279)
1.3 7.9 GO:0000235 astral microtubule(GO:0000235)
0.8 6.7 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.6 6.6 GO:0031931 TORC1 complex(GO:0031931)
0.3 6.6 GO:0030673 axolemma(GO:0030673)
0.1 6.5 GO:0055037 recycling endosome(GO:0055037)
0.1 6.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.5 32.6 GO:0045503 dynein light chain binding(GO:0045503)
0.3 27.8 GO:0008565 protein transporter activity(GO:0008565)
0.2 22.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 22.6 GO:0030276 clathrin binding(GO:0030276)
0.5 19.0 GO:0045296 cadherin binding(GO:0045296)
0.5 13.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 13.6 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.4 11.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
1.9 9.6 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.3 9.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.5 9.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 8.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 8.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 7.7 GO:0017124 SH3 domain binding(GO:0017124)
0.5 7.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 7.1 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.1 6.7 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.4 6.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.3 6.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 6.6 GO:0031625 ubiquitin protein ligase binding(GO:0031625)