Motif ID: Evx2

Z-value: 0.714


Transcription factors associated with Evx2:

Gene SymbolEntrez IDGene Name
Evx2 ENSMUSG00000001815.9 Evx2



Activity profile for motif Evx2.

activity profile for motif Evx2


Sorted Z-values histogram for motif Evx2

Sorted Z-values for motif Evx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Evx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_60893430 12.649 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr2_-_168767136 10.350 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr2_-_168767029 7.534 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr13_+_51645232 7.314 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr4_+_109978004 5.393 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr2_+_91257323 5.340 ENSMUST00000111349.2
ENSMUST00000131711.1
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr2_+_91256813 5.336 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
 Pacsin3



protein kinase C and casein kinase substrate in neurons 3



chr18_-_88927447 4.456 ENSMUST00000147313.1
 Socs6
suppressor of cytokine signaling 6
chr14_+_62292475 4.354 ENSMUST00000166879.1
 Rnaseh2b
ribonuclease H2, subunit B
chrX_+_58030999 4.308 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr4_-_132345686 4.207 ENSMUST00000030726.6
 Rcc1
regulator of chromosome condensation 1
chr5_-_98030727 4.203 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr4_-_132345715 4.031 ENSMUST00000084250.4
 Rcc1
regulator of chromosome condensation 1
chr2_-_155074447 3.948 ENSMUST00000137242.1
ENSMUST00000054607.9
 Ahcy

S-adenosylhomocysteine hydrolase

chr2_+_119047116 3.907 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr2_+_119047129 3.470 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr6_-_124779686 3.437 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr7_+_51879041 3.198 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr10_-_8886033 3.124 ENSMUST00000015449.5
 Sash1
SAM and SH3 domain containing 1
chr7_-_126800354 3.109 ENSMUST00000106348.1
 Aldoa
aldolase A, fructose-bisphosphate
chr17_+_17402672 2.949 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr11_+_60537978 2.926 ENSMUST00000044250.3
 Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chrX_+_58030622 2.886 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr4_-_132075250 2.587 ENSMUST00000105970.1
ENSMUST00000105975.1
 Epb4.1

erythrocyte protein band 4.1

chr4_+_140701466 2.166 ENSMUST00000038893.5
ENSMUST00000138808.1
 Rcc2

regulator of chromosome condensation 2

chr4_-_42661893 2.160 ENSMUST00000108006.3
 Il11ra2
interleukin 11 receptor, alpha chain 2
chr4_-_129227883 1.876 ENSMUST00000106051.1
 C77080
expressed sequence C77080
chr7_-_143460989 1.862 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr9_-_66514567 1.687 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr17_-_47834682 1.627 ENSMUST00000066368.6
 Mdfi
MyoD family inhibitor
chr15_+_34453285 1.603 ENSMUST00000060894.7
 BC030476
cDNA sequence BC030476
chr2_+_154548888 1.527 ENSMUST00000045116.4
ENSMUST00000109709.3
 1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr19_+_47067721 1.333 ENSMUST00000026027.5
 Taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr2_-_132247747 1.271 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
 Tmem230


transmembrane protein 230


chr3_+_121291725 1.222 ENSMUST00000039442.7
 Alg14
asparagine-linked glycosylation 14
chr14_+_73173825 1.167 ENSMUST00000166875.1
 Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr3_-_130709419 0.903 ENSMUST00000043937.7
 Ostc
oligosaccharyltransferase complex subunit
chr2_-_150255591 0.794 ENSMUST00000063463.5
 Gm21994
predicted gene 21994
chr17_-_49564262 0.782 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr15_-_58034289 0.750 ENSMUST00000100655.3
 9130401M01Rik
RIKEN cDNA 9130401M01 gene
chrX_-_111536325 0.713 ENSMUST00000156639.1
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr17_+_36837123 0.705 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
 Trim26





tripartite motif-containing 26





chr14_+_48446128 0.683 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chrX_-_57338598 0.642 ENSMUST00000033468.4
ENSMUST00000114736.1
 Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr6_-_69400097 0.536 ENSMUST00000177795.1
 Igkv4-62
immunoglobulin kappa variable 4-62
chr6_-_69284319 0.376 ENSMUST00000103349.1
 Igkv4-69
immunoglobulin kappa variable 4-69
chr2_-_27475622 0.375 ENSMUST00000138693.1
ENSMUST00000113941.2
ENSMUST00000077737.6
 Brd3


bromodomain containing 3


chr19_+_5088534 0.355 ENSMUST00000025811.4
 Yif1a
Yip1 interacting factor homolog A (S. cerevisiae)
chr4_+_100478806 0.293 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
 Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr8_-_31168699 0.217 ENSMUST00000033983.4
 Mak16
MAK16 homolog (S. cerevisiae)
chr9_+_47530173 0.215 ENSMUST00000114548.1
ENSMUST00000152459.1
ENSMUST00000143026.1
ENSMUST00000085909.2
ENSMUST00000114547.1
ENSMUST00000034581.3
 Cadm1





cell adhesion molecule 1





chr13_+_38204928 0.184 ENSMUST00000091641.5
ENSMUST00000178564.1
 Snrnp48

small nuclear ribonucleoprotein 48 (U11/U12)

chr6_+_116650674 0.163 ENSMUST00000067354.5
ENSMUST00000178241.1
 8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr14_-_59365410 0.095 ENSMUST00000161031.1
ENSMUST00000160425.1
 Phf11d

PHD finger protein 11D

chr7_+_27927592 0.066 ENSMUST00000181644.1
 Gm26891
predicted gene, 26891

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
1.0 3.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
1.0 17.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.7 2.9 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.7 2.2 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.7 12.6 GO:0007530 sex determination(GO:0007530)
0.6 7.4 GO:0034501 protein localization to kinetochore(GO:0034501)
0.5 3.9 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.5 10.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.3 5.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.3 3.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 4.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 2.9 GO:0097352 autophagosome maturation(GO:0097352)
0.1 1.6 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 8.2 GO:0007052 mitotic spindle organization(GO:0007052)
0.1 4.2 GO:1901998 toxin transport(GO:1901998)
0.1 1.9 GO:0060065 uterus development(GO:0060065)
0.1 6.0 GO:0007127 meiosis I(GO:0007127)
0.1 0.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 4.5 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 0.7 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.7 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 3.2 GO:0007050 cell cycle arrest(GO:0007050)
0.0 1.3 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 2.2 GO:1990023 mitotic spindle midzone(GO:1990023)
0.2 21.3 GO:0000792 heterochromatin(GO:0000792)
0.1 8.2 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 8.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 4.5 GO:0001772 immunological synapse(GO:0001772)
0.1 0.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 1.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 10.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.9 GO:0016607 nuclear speck(GO:0016607)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 8.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.7 2.9 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.7 10.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.6 3.9 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.5 4.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.5 3.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 12.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 9.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 3.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 3.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 2.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 30.6 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.8 GO:0017048 Rho GTPase binding(GO:0017048)