Motif ID: Ezh2_Atf2_Ikzf1

Z-value: 1.968

Transcription factors associated with Ezh2_Atf2_Ikzf1:

Gene SymbolEntrez IDGene Name
Atf2 ENSMUSG00000027104.12 Atf2
Ezh2 ENSMUSG00000029687.10 Ezh2
Ikzf1 ENSMUSG00000018654.11 Ikzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf2mm10_v2_chr2_-_73892588_738926160.859.3e-21Click!
Ezh2mm10_v2_chr6_-_47594967_47595047-0.019.6e-01Click!


Activity profile for motif Ezh2_Atf2_Ikzf1.

activity profile for motif Ezh2_Atf2_Ikzf1


Sorted Z-values histogram for motif Ezh2_Atf2_Ikzf1

Sorted Z-values for motif Ezh2_Atf2_Ikzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ezh2_Atf2_Ikzf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_152081529 49.483 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr4_-_82505749 32.532 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505707 28.733 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr13_+_54371340 25.333 ENSMUST00000026985.8
 Cplx2
complexin 2
chr16_-_23520579 21.162 ENSMUST00000089883.5
 Masp1
mannan-binding lectin serine peptidase 1
chr10_-_102490418 19.334 ENSMUST00000020040.3
 Nts
neurotensin
chr4_+_101550411 18.516 ENSMUST00000094953.4
ENSMUST00000106933.1
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr5_+_98180866 18.266 ENSMUST00000112959.1
 Prdm8
PR domain containing 8
chr1_-_154725920 17.162 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr2_+_4300462 16.868 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr17_-_90455872 16.710 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr1_+_66175286 16.441 ENSMUST00000114017.1
ENSMUST00000114015.1
 Map2

microtubule-associated protein 2

chrX_-_73869804 16.134 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr15_-_76521902 15.976 ENSMUST00000164703.1
ENSMUST00000096365.3
 Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr12_-_78980758 15.747 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr7_+_126950687 15.130 ENSMUST00000106333.1
 Sez6l2
seizure related 6 homolog like 2
chr14_-_79771305 15.038 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr11_-_118909487 14.566 ENSMUST00000117731.1
ENSMUST00000106278.2
ENSMUST00000120061.1
ENSMUST00000017576.4
 Rbfox3



RNA binding protein, fox-1 homolog (C. elegans) 3



chr9_+_27790947 14.523 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr7_+_126950518 14.438 ENSMUST00000106335.1
ENSMUST00000146017.1
 Sez6l2

seizure related 6 homolog like 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 393 entries
Log-likelihood per target Total log-likelihoodTermDescription
16.0 64.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
1.4 58.9 GO:2001222 regulation of neuron migration(GO:2001222)
0.6 52.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.6 43.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.8 40.5 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.5 39.9 GO:0007612 learning(GO:0007612)
0.8 34.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.9 31.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.4 26.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.8 25.8 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.5 25.4 GO:0008542 visual learning(GO:0008542)
4.9 24.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
4.6 23.0 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
3.0 21.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
2.4 19.3 GO:0097369 sodium ion import(GO:0097369)
0.2 19.0 GO:0071805 potassium ion transmembrane transport(GO:0071805)
3.1 18.5 GO:0072318 clathrin coat disassembly(GO:0072318)
1.7 18.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.0 18.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
3.6 17.8 GO:2000481 positive regulation of cAMP-dependent protein kinase activity(GO:2000481)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 172 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 78.8 GO:0042734 presynaptic membrane(GO:0042734)
3.3 68.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
5.3 47.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 45.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 40.0 GO:0060076 excitatory synapse(GO:0060076)
1.6 32.0 GO:0016514 SWI/SNF complex(GO:0016514)
1.8 31.0 GO:0032279 asymmetric synapse(GO:0032279)
0.7 29.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
2.2 28.2 GO:0042788 polysomal ribosome(GO:0042788)
0.2 26.0 GO:0000118 histone deacetylase complex(GO:0000118)
6.3 25.3 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
1.6 18.1 GO:0032584 growth cone membrane(GO:0032584)
1.1 17.9 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 17.4 GO:0005923 bicellular tight junction(GO:0005923)
0.2 16.4 GO:0035097 histone methyltransferase complex(GO:0035097)
0.6 15.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
2.3 13.7 GO:0044308 axonal spine(GO:0044308)
0.1 13.0 GO:0043209 myelin sheath(GO:0043209)
0.2 12.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 12.1 GO:0030424 axon(GO:0030424)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 277 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 57.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
5.7 45.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.5 39.0 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
1.5 35.6 GO:0017075 syntaxin-1 binding(GO:0017075)
4.6 32.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 29.1 GO:0008017 microtubule binding(GO:0008017)
2.4 29.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.4 24.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
1.4 23.9 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
1.1 23.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
1.7 23.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 22.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 21.8 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738) protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
2.3 18.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 17.9 GO:0042393 histone binding(GO:0042393)
3.0 17.7 GO:0005042 netrin receptor activity(GO:0005042)
0.9 17.7 GO:0031402 sodium ion binding(GO:0031402)
0.1 16.7 GO:0030674 protein binding, bridging(GO:0030674)
3.2 16.2 GO:0033691 sialic acid binding(GO:0033691)
2.6 15.8 GO:0032051 clathrin light chain binding(GO:0032051)