Motif ID: Fli1

Z-value: 1.514


Transcription factors associated with Fli1:

Gene SymbolEntrez IDGene Name
Fli1 ENSMUSG00000016087.7 Fli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fli1mm10_v2_chr9_-_32541589_32541602-0.301.2e-02Click!


Activity profile for motif Fli1.

activity profile for motif Fli1


Sorted Z-values histogram for motif Fli1

Sorted Z-values for motif Fli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Fli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 155 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_175491130 49.934 ENSMUST00000027812.5
 Rgs7
regulator of G protein signaling 7
chrX_-_136868537 46.646 ENSMUST00000058814.6
 Rab9b
RAB9B, member RAS oncogene family
chr11_+_32000452 40.910 ENSMUST00000020537.2
ENSMUST00000109409.1
 Nsg2

neuron specific gene family member 2

chr11_+_32000496 35.343 ENSMUST00000093219.3
 Nsg2
neuron specific gene family member 2
chr7_-_140082489 27.032 ENSMUST00000026541.7
 Caly
calcyon neuron-specific vesicular protein
chr4_+_43406435 25.541 ENSMUST00000098106.2
ENSMUST00000139198.1
 Rusc2

RUN and SH3 domain containing 2

chr1_-_126492900 22.568 ENSMUST00000161954.1
 Nckap5
NCK-associated protein 5
chr10_+_26229707 21.930 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_-_191318090 18.419 ENSMUST00000046770.9
 Nenf
neuron derived neurotrophic factor
chr2_+_65845767 15.496 ENSMUST00000122912.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr16_-_42340595 14.871 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr6_-_77979515 14.871 ENSMUST00000159626.1
ENSMUST00000075340.5
ENSMUST00000162273.1
 Ctnna2


catenin (cadherin associated protein), alpha 2


chr2_+_65845833 14.459 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr6_-_77979652 14.381 ENSMUST00000161846.1
ENSMUST00000160894.1
 Ctnna2

catenin (cadherin associated protein), alpha 2

chr5_+_117133567 12.835 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
 Taok3


TAO kinase 3


chr15_-_76521902 11.465 ENSMUST00000164703.1
ENSMUST00000096365.3
 Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr12_+_86678685 11.243 ENSMUST00000021681.3
 Vash1
vasohibin 1
chr8_+_23035116 10.448 ENSMUST00000117296.1
ENSMUST00000141784.2
 Ank1

ankyrin 1, erythroid

chr10_+_69533761 10.153 ENSMUST00000182884.1
 Ank3
ankyrin 3, epithelial
chr13_-_51203065 9.349 ENSMUST00000091708.4
 Hist1h2al
histone cluster 1, H2al

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 101.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.4 49.9 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.6 46.6 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
2.9 31.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 30.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
2.4 29.3 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.5 19.2 GO:0033014 porphyrin-containing compound biosynthetic process(GO:0006779) tetrapyrrole biosynthetic process(GO:0033014)
1.7 18.4 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.9 17.4 GO:0045838 positive regulation of membrane potential(GO:0045838)
1.7 14.9 GO:0016198 axon choice point recognition(GO:0016198)
0.7 12.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.3 11.5 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 11.5 GO:0007631 feeding behavior(GO:0007631)
2.8 11.2 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 9.9 GO:0006821 chloride transport(GO:0006821)
0.3 9.1 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
1.5 9.0 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
2.6 7.7 GO:0009644 response to high light intensity(GO:0009644)
2.3 6.9 GO:0071336 lung growth(GO:0060437) positive regulation of fat cell proliferation(GO:0070346) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.5 6.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 102.5 GO:0031410 cytoplasmic vesicle(GO:0031410)
2.6 51.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
3.6 49.9 GO:0044292 dendrite terminus(GO:0044292)
0.8 46.6 GO:0045335 phagocytic vesicle(GO:0045335)
0.4 28.1 GO:0005913 cell-cell adherens junction(GO:0005913)
2.7 16.4 GO:0044308 axonal spine(GO:0044308)
0.8 14.9 GO:0031527 filopodium membrane(GO:0031527)
0.1 11.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 9.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.5 9.1 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
1.0 7.7 GO:0001520 outer dense fiber(GO:0001520)
0.0 7.1 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 7.0 GO:0045202 synapse(GO:0045202)
0.2 6.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 6.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 6.4 GO:0005923 bicellular tight junction(GO:0005923)
0.2 5.9 GO:0009925 basal plasma membrane(GO:0009925)
0.0 5.4 GO:0005768 endosome(GO:0005768)
0.1 4.7 GO:0043204 perikaryon(GO:0043204)
1.5 4.6 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
17.2 103.3 GO:0032051 clathrin light chain binding(GO:0032051)
3.7 66.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
1.7 51.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.8 47.5 GO:0019003 GDP binding(GO:0019003)
0.8 28.1 GO:0045296 cadherin binding(GO:0045296)
0.1 23.4 GO:0017137 Rab GTPase binding(GO:0017137)
2.5 14.9 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 11.0 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.8 9.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3 9.0 GO:0070412 R-SMAD binding(GO:0070412)
0.1 7.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 7.7 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.1 7.7 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.7 7.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.4 7.0 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
1.7 6.9 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 6.9 GO:0051117 ATPase binding(GO:0051117)
0.2 6.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.6 6.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 6.0 GO:0017124 SH3 domain binding(GO:0017124)