Motif ID: Fosb

Z-value: 0.470


Transcription factors associated with Fosb:

Gene SymbolEntrez IDGene Name
Fosb ENSMUSG00000003545.2 Fosb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosbmm10_v2_chr7_-_19310035_19310050-0.681.1e-10Click!


Activity profile for motif Fosb.

activity profile for motif Fosb


Sorted Z-values histogram for motif Fosb

Sorted Z-values for motif Fosb



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_118663235 4.763 ENSMUST00000099557.3
 Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr14_+_80000292 4.417 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr14_+_27622433 4.394 ENSMUST00000090302.5
 Erc2
ELKS/RAB6-interacting/CAST family member 2
chr6_+_17463927 4.155 ENSMUST00000115442.1
 Met
met proto-oncogene
chr3_+_55461758 4.003 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr4_+_42158092 3.829 ENSMUST00000098122.2
 Gm13306
predicted gene 13306
chr11_-_100397740 2.965 ENSMUST00000001592.8
ENSMUST00000107403.1
 Jup

junction plakoglobin

chr6_-_124769548 2.819 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr16_+_78930940 2.572 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
 Chodl


chondrolectin


chr13_-_113663670 2.565 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr10_+_26078255 2.482 ENSMUST00000041011.3
 Gm9767
predicted gene 9767
chr8_-_8639363 2.454 ENSMUST00000152698.1
 Efnb2
ephrin B2
chr1_-_12991109 2.443 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr9_+_104566677 2.422 ENSMUST00000157006.1
 Cpne4
copine IV
chr2_-_29253001 2.392 ENSMUST00000071201.4
 Ntng2
netrin G2
chr16_-_4880284 2.321 ENSMUST00000037843.6
 Ubald1
UBA-like domain containing 1
chr3_+_123267445 2.282 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr15_+_102503722 2.082 ENSMUST00000096145.4
 Gm10337
predicted gene 10337
chr6_+_86849488 2.055 ENSMUST00000089519.6
ENSMUST00000113668.1
 Aak1

AP2 associated kinase 1

chr6_-_113934679 2.024 ENSMUST00000101044.2
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr1_+_134560190 1.982 ENSMUST00000112198.1
ENSMUST00000112197.1
 Kdm5b

lysine (K)-specific demethylase 5B

chr7_+_126776939 1.860 ENSMUST00000038614.5
ENSMUST00000170882.1
ENSMUST00000106359.1
ENSMUST00000106357.1
ENSMUST00000145762.1
ENSMUST00000132643.1
ENSMUST00000106356.1
 Ypel3






yippee-like 3 (Drosophila)






chr1_+_134560157 1.854 ENSMUST00000047714.7
 Kdm5b
lysine (K)-specific demethylase 5B
chr2_+_156475844 1.749 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr2_-_151632471 1.636 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr19_+_5447692 1.608 ENSMUST00000025850.5
 Fosl1
fos-like antigen 1
chr7_-_4778141 1.550 ENSMUST00000094892.5
 Il11
interleukin 11
chr13_-_54611274 1.477 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr9_-_109059216 1.378 ENSMUST00000112053.1
 Trex1
three prime repair exonuclease 1
chr2_+_156475803 1.368 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr13_-_54611332 1.367 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr2_-_45110241 1.351 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr14_+_79426454 1.284 ENSMUST00000061222.7
 Kbtbd7
kelch repeat and BTB (POZ) domain containing 7
chr11_-_120630516 1.280 ENSMUST00000106181.1
 Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr3_+_109573907 1.247 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr8_+_36489191 1.212 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr8_+_107293500 1.165 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
 Nfat5


nuclear factor of activated T cells 5


chr10_+_116143881 1.136 ENSMUST00000105271.2
 Ptprr
protein tyrosine phosphatase, receptor type, R
chr3_-_88503331 1.010 ENSMUST00000029699.6
 Lmna
lamin A
chr3_-_88503187 1.008 ENSMUST00000120377.1
 Lmna
lamin A
chrX_-_75578188 0.958 ENSMUST00000033545.5
 Rab39b
RAB39B, member RAS oncogene family
chr9_-_109059711 0.949 ENSMUST00000061973.4
 Trex1
three prime repair exonuclease 1
chr12_+_71015966 0.836 ENSMUST00000046305.5
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr11_-_84067063 0.834 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr11_-_50210765 0.831 ENSMUST00000143379.1
ENSMUST00000015981.5
ENSMUST00000102774.4
 Sqstm1


sequestosome 1


chr15_-_102257306 0.787 ENSMUST00000135466.1
 Rarg
retinoic acid receptor, gamma
chr1_-_51915968 0.760 ENSMUST00000046390.7
 Myo1b
myosin IB
chr6_-_129533267 0.756 ENSMUST00000181594.1
 1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr15_-_76014318 0.748 ENSMUST00000060807.5
 Fam83h
family with sequence similarity 83, member H
chr15_-_102257449 0.727 ENSMUST00000043172.8
 Rarg
retinoic acid receptor, gamma
chr11_+_77801325 0.722 ENSMUST00000151373.2
ENSMUST00000172303.2
ENSMUST00000130305.2
ENSMUST00000164334.1
ENSMUST00000092884.4
 Myo18a




myosin XVIIIA




chr18_-_31317043 0.707 ENSMUST00000139924.1
ENSMUST00000153060.1
 Rit2

Ras-like without CAAX 2

chr11_+_77801291 0.691 ENSMUST00000100794.3
 Myo18a
myosin XVIIIA
chr12_-_85288419 0.668 ENSMUST00000121930.1
 Acyp1
acylphosphatase 1, erythrocyte (common) type
chr17_-_45592485 0.651 ENSMUST00000166119.1
 Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr7_-_127946725 0.643 ENSMUST00000118755.1
ENSMUST00000094026.3
 Prss36

protease, serine, 36

chr17_+_46161021 0.571 ENSMUST00000024748.7
ENSMUST00000172170.1
 Gtpbp2

GTP binding protein 2

chr7_-_29505447 0.541 ENSMUST00000183096.1
ENSMUST00000085809.4
 Sipa1l3

signal-induced proliferation-associated 1 like 3

chr10_-_64090265 0.522 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr17_-_45592262 0.520 ENSMUST00000164769.1
 Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr8_+_4226827 0.515 ENSMUST00000053035.6
 Lrrc8e
leucine rich repeat containing 8 family, member E
chr16_+_17561885 0.496 ENSMUST00000171002.1
ENSMUST00000023441.4
 P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr5_-_21785115 0.491 ENSMUST00000115193.1
ENSMUST00000115192.1
ENSMUST00000115195.1
ENSMUST00000030771.5
 Dnajc2



DnaJ (Hsp40) homolog, subfamily C, member 2



chr7_+_30413744 0.487 ENSMUST00000032800.9
 Tyrobp
TYRO protein tyrosine kinase binding protein
chr2_+_143915273 0.481 ENSMUST00000103172.3
 Dstn
destrin
chrX_+_73675500 0.473 ENSMUST00000171398.1
 Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr2_-_18048784 0.451 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chr11_-_3914664 0.449 ENSMUST00000109995.1
ENSMUST00000051207.1
 Slc35e4

solute carrier family 35, member E4

chr11_+_80428598 0.424 ENSMUST00000173938.1
ENSMUST00000017572.7
 Psmd11

proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

chr10_-_64090241 0.414 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr18_+_40258361 0.413 ENSMUST00000091927.4
 Kctd16
potassium channel tetramerisation domain containing 16
chr9_+_122888471 0.355 ENSMUST00000063980.6
 Zkscan7
zinc finger with KRAB and SCAN domains 7
chr3_-_88177671 0.342 ENSMUST00000181837.1
 1700113A16Rik
RIKEN cDNA 1700113A16 gene
chr11_-_96075655 0.322 ENSMUST00000090541.5
 Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr7_-_100547620 0.301 ENSMUST00000064334.2
 D630004N19Rik
RIKEN cDNA D630004N19 gene
chr11_-_96075581 0.259 ENSMUST00000107686.1
ENSMUST00000107684.1
 Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr2_+_164948219 0.207 ENSMUST00000017881.2
 Mmp9
matrix metallopeptidase 9
chr14_-_55758458 0.109 ENSMUST00000001497.7
 Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr2_+_30441831 0.024 ENSMUST00000131476.1
 Ppp2r4
protein phosphatase 2A, regulatory subunit B (PR 53)
chr1_+_86064619 0.015 ENSMUST00000027432.8
 Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr11_+_78188737 0.011 ENSMUST00000108322.2
 Rab34
RAB34, member of RAS oncogene family
chr4_-_140665891 0.009 ENSMUST00000069623.5
 Arhgef10l
Rho guanine nucleotide exchange factor (GEF) 10-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0002159 desmosome assembly(GO:0002159)
0.5 2.0 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.5 3.8 GO:0034720 positive regulation of mammary gland epithelial cell proliferation(GO:0033601) histone H3-K4 demethylation(GO:0034720) mammary duct terminal end bud growth(GO:0060763)
0.5 1.9 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.5 4.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.4 1.5 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430) Harderian gland development(GO:0070384)
0.3 2.0 GO:0048840 otolith development(GO:0048840)
0.3 2.5 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.3 1.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.3 1.4 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
0.2 1.6 GO:0007296 vitellogenesis(GO:0007296)
0.2 1.4 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 2.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 1.2 GO:0015862 uridine transport(GO:0015862)
0.1 0.6 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.8 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 4.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.8 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 2.1 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.1 4.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.5 GO:2001204 regulation of osteoclast development(GO:2001204)
0.1 2.3 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 0.9 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.1 1.2 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1 2.8 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 1.2 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.5 GO:0030836 positive regulation of actin filament depolymerization(GO:0030836) actin filament severing(GO:0051014)
0.0 0.2 GO:0031915 positive regulation of synaptic plasticity(GO:0031915) regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549) positive regulation of receptor binding(GO:1900122)
0.0 4.8 GO:0007613 memory(GO:0007613)
0.0 2.8 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 1.6 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.0 0.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.5 GO:0033198 response to ATP(GO:0033198)
0.0 2.3 GO:0001701 in utero embryonic development(GO:0001701)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 1.6 GO:0046888 negative regulation of hormone secretion(GO:0046888)
0.0 0.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.7 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.5 GO:0072337 modified amino acid transport(GO:0072337)
0.0 0.5 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.0 0.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.3 2.1 GO:0071439 clathrin complex(GO:0071439)
0.3 4.4 GO:0042581 specific granule(GO:0042581)
0.3 3.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.3 2.0 GO:0005638 lamin filament(GO:0005638)
0.3 0.8 GO:0044754 amphisome(GO:0044753) autolysosome(GO:0044754)
0.3 2.8 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 4.4 GO:0048786 presynaptic active zone(GO:0048786)
0.1 0.5 GO:0061689 tricellular tight junction(GO:0061689)
0.1 2.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.7 GO:0045095 keratin filament(GO:0045095)
0.1 3.7 GO:0042734 presynaptic membrane(GO:0042734)
0.1 4.2 GO:0009925 basal plasma membrane(GO:0009925)
0.1 2.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 2.2 GO:0016459 myosin complex(GO:0016459)
0.0 0.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.4 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 4.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
1.0 4.2 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.6 2.3 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.3 2.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.3 2.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 3.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 2.4 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.2 0.7 GO:1990254 keratin filament binding(GO:1990254)
0.2 0.7 GO:0003998 acylphosphatase activity(GO:0003998)
0.2 2.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 2.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 0.5 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 4.4 GO:0045296 cadherin binding(GO:0045296)
0.1 0.5 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 1.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 2.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 1.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 2.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 1.0 GO:0031489 myosin V binding(GO:0031489)
0.0 1.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 4.8 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.8 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 1.4 GO:0043531 ADP binding(GO:0043531)
0.0 4.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.6 GO:0005125 cytokine activity(GO:0005125) growth factor activity(GO:0008083)
0.0 1.2 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.0 2.6 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)