Motif ID: Fosl2_Bach2

Z-value: 0.668

Transcription factors associated with Fosl2_Bach2:

Gene SymbolEntrez IDGene Name
Bach2 ENSMUSG00000040270.10 Bach2
Fosl2 ENSMUSG00000029135.9 Fosl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosl2mm10_v2_chr5_+_32136458_321365050.774.2e-15Click!
Bach2mm10_v2_chr4_+_32238950_322389640.517.0e-06Click!


Activity profile for motif Fosl2_Bach2.

activity profile for motif Fosl2_Bach2


Sorted Z-values histogram for motif Fosl2_Bach2

Sorted Z-values for motif Fosl2_Bach2



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosl2_Bach2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_33907721 11.272 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr6_+_17463927 7.090 ENSMUST00000115442.1
 Met
met proto-oncogene
chr3_+_55461758 6.050 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr18_+_32938955 5.545 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr9_-_20728219 5.141 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr6_-_124769548 5.031 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal


chr8_+_95703037 4.915 ENSMUST00000073139.7
ENSMUST00000080666.7
 Ndrg4

N-myc downstream regulated gene 4

chr14_+_27622433 4.870 ENSMUST00000090302.5
 Erc2
ELKS/RAB6-interacting/CAST family member 2
chr6_+_124996681 4.611 ENSMUST00000032479.4
 Pianp
PILR alpha associated neural protein
chr7_+_126776939 4.359 ENSMUST00000038614.5
ENSMUST00000170882.1
ENSMUST00000106359.1
ENSMUST00000106357.1
ENSMUST00000145762.1
ENSMUST00000132643.1
ENSMUST00000106356.1
 Ypel3






yippee-like 3 (Drosophila)






chr2_-_45110241 4.300 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr2_+_156475803 4.105 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr13_+_54949388 4.091 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr2_-_151632471 4.051 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr2_+_156475844 3.943 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr18_+_37955544 3.914 ENSMUST00000070709.2
ENSMUST00000177058.1
ENSMUST00000169360.2
ENSMUST00000163591.2
ENSMUST00000091932.5
 Rell2




RELT-like 2




chr13_-_54611274 3.772 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr9_+_60712989 3.662 ENSMUST00000038407.5
 Larp6
La ribonucleoprotein domain family, member 6
chr17_-_56133817 3.616 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr13_-_54611332 3.587 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 11.6 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.3 11.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.6 9.2 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.1 8.9 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.7 6.9 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
1.7 6.8 GO:1904177 regulation of adipose tissue development(GO:1904177)
1.0 6.1 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 6.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.4 5.1 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 5.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.4 4.9 GO:2001135 regulation of endocytic recycling(GO:2001135)
1.1 4.4 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.2 4.3 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
1.0 4.1 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.5 4.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 3.6 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.2 3.5 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.2 3.5 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 3.5 GO:0006417 regulation of translation(GO:0006417)
0.9 3.4 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.6 GO:0042734 presynaptic membrane(GO:0042734)
0.2 10.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 9.5 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529) ribonucleoprotein complex(GO:1990904)
0.7 7.4 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
1.0 6.8 GO:0005638 lamin filament(GO:0005638)
0.0 6.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 6.2 GO:0005604 basement membrane(GO:0005604)
0.0 6.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 6.0 GO:0016324 apical plasma membrane(GO:0016324)
0.0 5.6 GO:0055037 recycling endosome(GO:0055037)
0.1 5.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.0 5.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.0 4.1 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.1 4.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 3.7 GO:0031253 cell projection membrane(GO:0031253)
0.0 3.6 GO:0043198 dendritic shaft(GO:0043198)
0.5 3.5 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.8 3.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.1 3.3 GO:0031985 Golgi cisterna(GO:0031985)
0.4 3.2 GO:0001520 outer dense fiber(GO:0001520)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 11.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.3 11.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.8 7.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.3 7.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 7.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 6.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 6.7 GO:0042805 actinin binding(GO:0042805)
0.1 6.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 5.9 GO:0008017 microtubule binding(GO:0008017)
0.2 5.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 5.3 GO:0005518 collagen binding(GO:0005518)
0.0 5.2 GO:0005096 GTPase activator activity(GO:0005096)
0.6 5.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 4.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.7 4.1 GO:0005042 netrin receptor activity(GO:0005042)
0.5 4.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 4.1 GO:0030165 PDZ domain binding(GO:0030165)
0.1 3.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 3.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 3.5 GO:0051787 misfolded protein binding(GO:0051787)