Motif ID: Foxa2_Foxa1

Z-value: 1.985

Transcription factors associated with Foxa2_Foxa1:

Gene SymbolEntrez IDGene Name
Foxa1 ENSMUSG00000035451.6 Foxa1
Foxa2 ENSMUSG00000037025.5 Foxa2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxa2mm10_v2_chr2_-_148046896_1480469910.457.9e-05Click!
Foxa1mm10_v2_chr12_-_57546121_575461410.343.5e-03Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_75152274 42.202 ENSMUST00000000476.8
Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr13_-_60177357 36.356 ENSMUST00000065086.4
Gas1
growth arrest specific 1
chr12_-_56535047 36.221 ENSMUST00000178477.2
Nkx2-1
NK2 homeobox 1
chr14_-_48662740 36.132 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr17_-_70851710 35.602 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chr2_+_25180737 35.043 ENSMUST00000104999.2
Nrarp
Notch-regulated ankyrin repeat protein
chr4_-_58499398 34.077 ENSMUST00000107570.1
Lpar1
lysophosphatidic acid receptor 1
chr14_+_73237891 30.674 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr6_+_5390387 29.964 ENSMUST00000183358.1
Asb4
ankyrin repeat and SOCS box-containing 4
chr10_-_93310963 26.240 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr7_+_113765998 25.658 ENSMUST00000046687.9
Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr10_-_93311073 24.299 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr18_-_84086379 22.349 ENSMUST00000060303.8
Tshz1
teashirt zinc finger family member 1
chr12_-_99883429 21.654 ENSMUST00000046485.3
Efcab11
EF-hand calcium binding domain 11
chr2_-_172940299 21.164 ENSMUST00000009143.7
Bmp7
bone morphogenetic protein 7
chr1_-_138619687 20.796 ENSMUST00000027642.2
Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
chr16_-_22439719 19.735 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr4_+_11191726 19.445 ENSMUST00000029866.9
ENSMUST00000108324.3
Ccne2

cyclin E2

chr11_-_68386821 19.430 ENSMUST00000021284.3
Ntn1
netrin 1
chr7_+_67655414 19.413 ENSMUST00000107470.1
Ttc23
tetratricopeptide repeat domain 23

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 50.6 GO:0042060 wound healing(GO:0042060)
15.7 47.2 GO:0021759 globus pallidus development(GO:0021759)
1.4 46.5 GO:0006270 DNA replication initiation(GO:0006270)
2.7 42.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
14.1 42.2 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
3.3 36.4 GO:0042473 outer ear morphogenesis(GO:0042473)
9.0 36.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.3 35.8 GO:0007638 mechanosensory behavior(GO:0007638)
3.2 35.0 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
8.5 34.1 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
3.0 30.0 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
4.8 28.9 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
9.1 27.2 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
3.2 25.6 GO:0048625 myoblast fate commitment(GO:0048625)
4.6 23.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
7.4 22.3 GO:0060023 soft palate development(GO:0060023)
7.1 21.2 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.0 20.8 GO:1904355 positive regulation of telomere capping(GO:1904355)
2.0 20.1 GO:0071763 nuclear membrane organization(GO:0071763)
1.7 19.2 GO:0060539 diaphragm development(GO:0060539)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 103.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 72.9 GO:0005654 nucleoplasm(GO:0005654)
0.2 68.7 GO:0005667 transcription factor complex(GO:0005667)
0.5 41.2 GO:0005902 microvillus(GO:0005902)
1.3 40.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 35.7 GO:0031225 anchored component of membrane(GO:0031225)
0.3 34.1 GO:0043198 dendritic shaft(GO:0043198)
7.5 30.0 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.7 27.8 GO:0005719 nuclear euchromatin(GO:0005719)
2.8 25.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 22.6 GO:0030426 growth cone(GO:0030426)
0.1 20.5 GO:0016323 basolateral plasma membrane(GO:0016323)
2.1 18.5 GO:0030478 actin cap(GO:0030478)
0.1 18.3 GO:0043296 apical junction complex(GO:0043296)
0.1 15.5 GO:0016324 apical plasma membrane(GO:0016324)
1.0 14.6 GO:0042555 MCM complex(GO:0042555)
1.4 14.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
3.5 14.1 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.2 13.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 11.8 GO:0030904 retromer complex(GO:0030904)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 87.8 GO:0001159 core promoter proximal region DNA binding(GO:0001159)
12.6 50.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
3.9 47.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
7.2 43.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
8.4 42.2 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
1.6 35.6 GO:0070410 co-SMAD binding(GO:0070410)
0.7 33.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
1.2 29.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 26.4 GO:0004930 G-protein coupled receptor activity(GO:0004930)
2.1 21.2 GO:0070700 BMP receptor binding(GO:0070700)
0.9 20.1 GO:0005521 lamin binding(GO:0005521)
0.9 18.4 GO:0042056 chemoattractant activity(GO:0042056)
0.7 17.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
1.0 16.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
3.3 16.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 16.5 GO:0051015 actin filament binding(GO:0051015)
1.6 16.0 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
3.2 15.9 GO:0015186 L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.7 14.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 14.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)