Motif ID: Foxc1

Z-value: 0.733


Transcription factors associated with Foxc1:

Gene SymbolEntrez IDGene Name
Foxc1 ENSMUSG00000050295.2 Foxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc1mm10_v2_chr13_+_31806627_318066500.262.7e-02Click!


Activity profile for motif Foxc1.

activity profile for motif Foxc1


Sorted Z-values histogram for motif Foxc1

Sorted Z-values for motif Foxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 177 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45311538 4.992 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chrY_+_1010543 4.091 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr12_-_73047179 3.444 ENSMUST00000050029.7
 Six1
sine oculis-related homeobox 1
chr14_-_48662740 3.362 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr6_+_47244359 3.326 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr1_+_72824482 2.945 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr1_-_71653162 2.675 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr10_+_77864623 2.498 ENSMUST00000092366.2
 Tspear
thrombospondin type laminin G domain and EAR repeats
chr1_+_107511489 2.483 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr17_-_70851710 2.397 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr1_+_107511416 2.385 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chrX_-_102252154 2.317 ENSMUST00000050551.3
 Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr7_-_75308373 2.233 ENSMUST00000085164.5
 Sv2b
synaptic vesicle glycoprotein 2 b
chr9_+_72806874 2.216 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr16_-_21947536 2.142 ENSMUST00000023562.7
 Tmem41a
transmembrane protein 41a
chr8_+_106870827 2.084 ENSMUST00000176144.1
ENSMUST00000175987.1
 Has3

hyaluronan synthase 3

chr13_-_54766553 2.054 ENSMUST00000036825.7
 Sncb
synuclein, beta
chr2_+_4976113 2.020 ENSMUST00000167607.1
ENSMUST00000115010.2
 Ucma

upper zone of growth plate and cartilage matrix associated

chr16_-_46155077 1.938 ENSMUST00000059524.5
 Gm4737
predicted gene 4737
chrX_-_102251852 1.934 ENSMUST00000101336.3
ENSMUST00000136277.1
 Cited1

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 5.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 4.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
1.1 4.3 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.3 4.1 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.2 3.8 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
1.1 3.4 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.8 3.4 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.7 3.3 GO:0071205 clustering of voltage-gated potassium channels(GO:0045163) protein localization to juxtaparanode region of axon(GO:0071205)
0.2 2.9 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.9 2.7 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161)
0.4 2.6 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.0 2.5 GO:0007605 sensory perception of sound(GO:0007605)
0.1 2.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 2.4 GO:0042417 dopamine metabolic process(GO:0042417)
0.0 2.3 GO:0098792 xenophagy(GO:0098792)
0.7 2.1 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0 2.0 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.5 1.8 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.0 1.8 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 1.8 GO:0006836 neurotransmitter transport(GO:0006836)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 4.4 GO:0016234 inclusion body(GO:0016234)
0.0 4.1 GO:0005667 transcription factor complex(GO:0005667)
0.2 3.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 2.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.9 2.7 GO:0005577 fibrinogen complex(GO:0005577)
0.1 2.4 GO:0032420 stereocilium(GO:0032420)
0.0 1.8 GO:0043195 terminal bouton(GO:0043195)
0.0 1.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.4 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 1.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 1.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 1.2 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 1.0 GO:0044613 nuclear pore central transport channel(GO:0044613) Flemming body(GO:0090543)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.0 1.0 GO:0005844 polysome(GO:0005844)
0.3 0.9 GO:1990037 Lewy body core(GO:1990037)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3 5.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 4.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 4.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.5 4.3 GO:0050693 LBD domain binding(GO:0050693)
0.0 4.0 GO:0002020 protease binding(GO:0002020)
0.4 2.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.3 2.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.4 2.7 GO:0045340 mercury ion binding(GO:0045340)
0.6 2.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 2.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.4 GO:0070410 co-SMAD binding(GO:0070410)
0.7 2.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 2.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 1.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 1.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.5 1.5 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 1.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.4 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 1.4 GO:0051117 ATPase binding(GO:0051117)