Motif ID: Foxc2

Z-value: 0.411


Transcription factors associated with Foxc2:

Gene SymbolEntrez IDGene Name
Foxc2 ENSMUSG00000046714.6 Foxc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc2mm10_v2_chr8_+_121116163_121116177-0.218.3e-02Click!


Activity profile for motif Foxc2.

activity profile for motif Foxc2


Sorted Z-values histogram for motif Foxc2

Sorted Z-values for motif Foxc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc2

PNG image of the network

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Top targets:


Showing 1 to 20 of 117 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84773381 6.323 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr9_+_53850243 3.988 ENSMUST00000048485.5
 Sln
sarcolipin
chr4_-_87806296 3.469 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr2_-_62483637 3.412 ENSMUST00000136686.1
ENSMUST00000102733.3
 Gcg

glucagon

chr4_+_48049080 3.371 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr1_+_177444653 2.884 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr11_+_32000452 2.773 ENSMUST00000020537.2
ENSMUST00000109409.1
 Nsg2

neuron specific gene family member 2

chr3_-_123672321 2.386 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr16_-_74411292 2.338 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr4_+_97777606 1.830 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr17_+_3532554 1.830 ENSMUST00000168560.1
 Cldn20
claudin 20
chr11_+_32000496 1.733 ENSMUST00000093219.3
 Nsg2
neuron specific gene family member 2
chr2_-_45110336 1.599 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr1_+_179546303 1.468 ENSMUST00000040706.8
 Cnst
consortin, connexin sorting protein
chr1_-_97977233 1.467 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase
chr2_-_65529275 1.411 ENSMUST00000126837.1
 Scn3a
sodium channel, voltage-gated, type III, alpha
chrX_+_163911401 1.271 ENSMUST00000140845.1
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr12_-_108003414 1.263 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr4_-_87806276 1.238 ENSMUST00000148059.1
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr17_+_70522083 1.187 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.5 4.7 GO:0007379 segment specification(GO:0007379)
0.2 4.5 GO:0048268 clathrin coat assembly(GO:0048268)
1.0 4.0 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
1.1 3.4 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.5 3.4 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.0 2.9 GO:0021766 hippocampus development(GO:0021766)
0.1 2.5 GO:0045792 negative regulation of cell size(GO:0045792)
0.8 2.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.4 2.2 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.1 2.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 2.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.1 1.9 GO:0070842 aggresome assembly(GO:0070842)
0.1 1.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 1.6 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.5 1.5 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.2 1.5 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 1.5 GO:0009404 toxin metabolic process(GO:0009404)
0.3 1.4 GO:0046684 response to pyrethroid(GO:0046684)
0.0 1.4 GO:0060074 synapse maturation(GO:0060074)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 4.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 4.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 2.9 GO:0045171 intercellular bridge(GO:0045171)
0.2 2.5 GO:0031931 TORC1 complex(GO:0031931)
0.1 2.3 GO:0030673 axolemma(GO:0030673)
0.0 1.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.5 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 1.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.0 GO:0031519 PcG protein complex(GO:0031519)
0.1 0.8 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.6 GO:0000145 exocyst(GO:0000145)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.5 GO:0032593 insulin-responsive compartment(GO:0032593)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.5 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 3.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 3.4 GO:0005179 hormone activity(GO:0005179)
0.3 2.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 1.6 GO:0070412 R-SMAD binding(GO:0070412)
0.5 1.5 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.3 1.5 GO:0071253 connexin binding(GO:0071253)
0.0 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.4 GO:0031402 sodium ion binding(GO:0031402)
0.1 1.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.2 1.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.1 GO:0042287 MHC protein binding(GO:0042287)
0.3 1.0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 1.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.9 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.9 GO:0002039 p53 binding(GO:0002039)
0.1 0.8 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.8 GO:0005518 collagen binding(GO:0005518)
0.0 0.7 GO:0050840 extracellular matrix binding(GO:0050840)