Motif ID: Foxi1_Foxo1

Z-value: 2.504

Transcription factors associated with Foxi1_Foxo1:

Gene SymbolEntrez IDGene Name
Foxi1 ENSMUSG00000047861.2 Foxi1
Foxo1 ENSMUSG00000044167.5 Foxo1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo1mm10_v2_chr3_+_52268337_522683880.152.0e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Foxi1_Foxo1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 79.290 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr17_-_70851710 55.303 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chr8_-_46294592 45.002 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr3_+_34649987 40.729 ENSMUST00000099151.2
Sox2
SRY-box containing gene 2
chr15_+_25752860 39.645 ENSMUST00000022882.5
ENSMUST00000135173.1
Myo10

myosin X

chr16_+_30065333 36.088 ENSMUST00000023171.7
Hes1
hairy and enhancer of split 1 (Drosophila)
chr4_-_143299498 35.807 ENSMUST00000030317.7
Pdpn
podoplanin
chr11_+_32276400 34.447 ENSMUST00000020531.2
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr7_-_37773555 34.336 ENSMUST00000176534.1
Zfp536
zinc finger protein 536
chr12_-_56535047 33.608 ENSMUST00000178477.2
Nkx2-1
NK2 homeobox 1
chr7_-_115824699 32.886 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr19_+_55741810 32.540 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr6_+_53573364 32.198 ENSMUST00000047450.7
Creb5
cAMP responsive element binding protein 5
chr3_-_52104891 30.745 ENSMUST00000121440.1
Maml3
mastermind like 3 (Drosophila)
chr4_-_143299463 29.918 ENSMUST00000119654.1
Pdpn
podoplanin
chr3_-_27153844 29.826 ENSMUST00000176242.2
ENSMUST00000176780.1
Ect2

ect2 oncogene

chr3_-_27153861 29.461 ENSMUST00000108300.1
ENSMUST00000108298.2
Ect2

ect2 oncogene

chr4_+_105157339 29.151 ENSMUST00000064139.7
Ppap2b
phosphatidic acid phosphatase type 2B
chr12_+_109452833 28.596 ENSMUST00000056110.8
Dlk1
delta-like 1 homolog (Drosophila)
chr9_+_78615501 28.245 ENSMUST00000093812.4
Cd109
CD109 antigen

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 485 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.6 100.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
5.8 93.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
4.8 90.9 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
13.2 79.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
6.0 66.2 GO:0061032 visceral serous pericardium development(GO:0061032)
3.0 65.0 GO:0006270 DNA replication initiation(GO:0006270)
7.0 62.8 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
2.3 57.2 GO:0007638 mechanosensory behavior(GO:0007638)
4.2 55.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
10.5 52.3 GO:0015671 oxygen transport(GO:0015671)
3.7 48.1 GO:0034501 protein localization to kinetochore(GO:0034501)
4.0 44.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
7.1 42.8 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
1.9 41.9 GO:0001967 suckling behavior(GO:0001967)
3.6 40.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
3.6 39.5 GO:0060539 diaphragm development(GO:0060539)
7.3 36.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
2.1 36.5 GO:0040034 regulation of development, heterochronic(GO:0040034)
12.0 36.1 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
1.1 35.9 GO:0042462 eye photoreceptor cell development(GO:0042462)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 193 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 409.9 GO:0005634 nucleus(GO:0005634)
0.5 210.2 GO:0005667 transcription factor complex(GO:0005667)
0.6 125.6 GO:0009897 external side of plasma membrane(GO:0009897)
2.5 116.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
19.2 96.1 GO:0097149 centralspindlin complex(GO:0097149)
4.8 72.0 GO:0042555 MCM complex(GO:0042555)
0.6 67.1 GO:0000776 kinetochore(GO:0000776)
0.7 57.1 GO:0005902 microvillus(GO:0005902)
6.0 54.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.9 51.0 GO:0016459 myosin complex(GO:0016459)
5.8 46.2 GO:0005833 hemoglobin complex(GO:0005833)
0.4 44.9 GO:0031513 nonmotile primary cilium(GO:0031513)
7.1 42.8 GO:0031262 Ndc80 complex(GO:0031262)
0.5 40.7 GO:0031225 anchored component of membrane(GO:0031225)
0.2 38.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
3.9 35.0 GO:0030478 actin cap(GO:0030478)
1.0 33.2 GO:0035371 microtubule plus-end(GO:0035371)
0.3 33.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
1.2 30.4 GO:0051233 spindle midzone(GO:0051233)
0.8 29.5 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 320 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 167.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 131.2 GO:0003677 DNA binding(GO:0003677)
3.5 91.4 GO:0008432 JUN kinase binding(GO:0008432)
0.6 88.0 GO:0051015 actin filament binding(GO:0051015)
1.9 86.3 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.9 83.1 GO:0017048 Rho GTPase binding(GO:0017048)
6.0 65.8 GO:0015250 water channel activity(GO:0015250)
1.4 65.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
3.6 53.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
10.5 52.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.5 52.0 GO:0005178 integrin binding(GO:0005178)
0.2 49.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
2.2 47.1 GO:0045295 gamma-catenin binding(GO:0045295)
3.6 46.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
1.8 44.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
9.9 39.7 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
1.2 37.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.8 37.1 GO:0003684 damaged DNA binding(GO:0003684)
2.6 36.5 GO:0051010 microtubule plus-end binding(GO:0051010)
2.9 34.5 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)