Motif ID: Foxo3

Z-value: 0.834


Transcription factors associated with Foxo3:

Gene SymbolEntrez IDGene Name
Foxo3 ENSMUSG00000048756.5 Foxo3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo3mm10_v2_chr10_-_42276744_422767630.612.6e-08Click!


Activity profile for motif Foxo3.

activity profile for motif Foxo3


Sorted Z-values histogram for motif Foxo3

Sorted Z-values for motif Foxo3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo3

PNG image of the network

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Top targets:


Showing 1 to 20 of 100 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84773381 15.764 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr14_-_51913393 12.179 ENSMUST00000004673.7
ENSMUST00000111632.3
 Ndrg2

N-myc downstream regulated gene 2

chr16_+_93683184 8.517 ENSMUST00000039620.6
 Cbr3
carbonyl reductase 3
chr11_-_101785252 7.016 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr16_-_22439719 6.223 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr2_-_51972990 5.132 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor

chr11_+_3332426 4.743 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr8_+_71568866 4.737 ENSMUST00000034267.4
 Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr2_+_124610573 4.628 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr2_-_51973219 4.607 ENSMUST00000028314.2
 Nmi
N-myc (and STAT) interactor
chr10_-_93310963 4.225 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr18_-_74961252 4.093 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr10_-_93311073 4.064 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr10_+_112271123 3.543 ENSMUST00000092175.2
 Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr3_-_145649970 3.494 ENSMUST00000029846.3
 Cyr61
cysteine rich protein 61
chr5_+_65131184 3.364 ENSMUST00000031089.5
ENSMUST00000101191.3
 Klhl5

kelch-like 5

chr18_-_39489776 3.348 ENSMUST00000025300.6
 Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr4_+_105157339 3.278 ENSMUST00000064139.7
 Ppap2b
phosphatidic acid phosphatase type 2B
chr5_+_66968416 3.191 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr10_+_40349265 3.177 ENSMUST00000044672.4
ENSMUST00000095743.2
 Cdk19

cyclin-dependent kinase 19


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 15.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.9 13.2 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.4 10.2 GO:0010574 regulation of vascular endothelial growth factor production(GO:0010574)
3.2 9.7 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.5 8.5 GO:0009109 coenzyme catabolic process(GO:0009109)
0.2 6.9 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 6.3 GO:0042060 wound healing(GO:0042060)
1.2 6.0 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.0 5.7 GO:0031032 actomyosin structure organization(GO:0031032)
0.9 4.7 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.7 4.7 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.4 4.1 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
1.2 3.5 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.4 3.5 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.1 3.2 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.5 2.8 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 2.1 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.1 1.8 GO:0060055 angiogenesis involved in wound healing(GO:0060055)
0.1 1.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.3 1.5 GO:0046549 retinal cone cell development(GO:0046549)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 41.8 GO:0005654 nucleoplasm(GO:0005654)
0.0 8.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 5.6 GO:0043197 dendritic spine(GO:0043197)
0.0 5.0 GO:0005769 early endosome(GO:0005769)
0.0 3.7 GO:0005901 caveola(GO:0005901)
0.1 3.5 GO:0030673 axolemma(GO:0030673)
0.1 3.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.8 GO:0005811 lipid particle(GO:0005811)
0.4 1.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 1.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)
0.0 1.4 GO:0005903 brush border(GO:0005903)
0.0 1.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.2 GO:0072562 blood microparticle(GO:0072562)
0.1 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.0 GO:0030139 endocytic vesicle(GO:0030139)
0.1 0.9 GO:0005922 connexon complex(GO:0005922)
0.0 0.7 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
2.8 8.5 GO:0000253 3-keto sterol reductase activity(GO:0000253)
2.1 8.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 6.9 GO:0030215 semaphorin receptor binding(GO:0030215)
1.5 6.0 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
1.6 4.7 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.5 4.7 GO:0015245 fatty acid transporter activity(GO:0015245)
1.0 4.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2 3.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 3.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 3.2 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 2.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 2.1 GO:0030276 clathrin binding(GO:0030276)
0.0 2.1 GO:0005125 cytokine activity(GO:0005125)
0.4 1.7 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.5 1.5 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 1.4 GO:0030507 spectrin binding(GO:0030507)
0.0 1.4 GO:0008238 exopeptidase activity(GO:0008238)
0.0 1.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4 1.2 GO:0001851 complement component C3b binding(GO:0001851)