Motif ID: Foxo4

Z-value: 0.659


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_1012545740.551.0e-06Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

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Top targets:


Showing 1 to 20 of 85 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_5796924 5.430 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr17_+_78508063 5.143 ENSMUST00000024880.9
 Vit
vitrin
chr4_-_97778042 3.965 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_+_8690399 3.226 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr7_-_89517576 2.990 ENSMUST00000041761.5
 Prss23
protease, serine, 23
chr8_-_105943382 2.810 ENSMUST00000038896.7
 Lcat
lecithin cholesterol acyltransferase
chr14_-_25903100 2.598 ENSMUST00000052286.8
 Plac9a
placenta specific 9a
chr5_-_70842617 2.513 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr14_-_26182480 2.486 ENSMUST00000184142.1
 Plac9b
placenta specific 9b
chr8_-_45410539 2.404 ENSMUST00000034056.4
ENSMUST00000167106.1
 Tlr3

toll-like receptor 3

chr11_-_102579461 2.291 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr2_+_181767283 2.275 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr2_-_175931051 2.253 ENSMUST00000108949.2
ENSMUST00000109018.2
 Gm8898

predicted gene 8898

chr2_+_181767040 2.156 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr7_-_25250720 1.964 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr2_-_175141999 1.931 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
 Gm14399


predicted gene 14399


chr2_-_175338197 1.878 ENSMUST00000121393.2
 Gm4631
predicted gene 4631
chr1_+_6487231 1.865 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr2_+_176521056 1.863 ENSMUST00000108997.2
ENSMUST00000178443.1
 Gm14431

predicted gene 14431

chr2_+_175469985 1.827 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
 Gm8923



predicted gene 8923




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 5.4 GO:0035063 nuclear speck organization(GO:0035063)
0.0 4.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.4 4.4 GO:0060539 diaphragm development(GO:0060539)
1.1 3.2 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.6 2.8 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.8 2.4 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.4 2.0 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.4 1.7 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.1 1.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 1.7 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.5 1.6 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.5 1.5 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 1.4 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 1.4 GO:0060074 synapse maturation(GO:0060074)
0.1 1.1 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.2 1.0 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 1.0 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0 1.0 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.6 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0016607 nuclear speck(GO:0016607)
0.3 5.1 GO:0005614 interstitial matrix(GO:0005614)
0.2 2.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.4 1.7 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.0 1.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.2 1.0 GO:0005861 troponin complex(GO:0005861)
0.1 1.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.5 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.3 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.0 4.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 3.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 3.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.7 2.8 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 2.5 GO:0050811 GABA receptor binding(GO:0050811)
0.0 2.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 2.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 1.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.5 1.6 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 1.5 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.1 GO:0015026 coreceptor activity(GO:0015026)
0.3 1.0 GO:0030172 troponin C binding(GO:0030172)
0.0 1.0 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 1.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 0.7 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)