Motif ID: Foxp2_Foxp3

Z-value: 0.635

Transcription factors associated with Foxp2_Foxp3:

Gene SymbolEntrez IDGene Name
Foxp2 ENSMUSG00000029563.10 Foxp2
Foxp3 ENSMUSG00000039521.6 Foxp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxp3mm10_v2_chrX_+_7579666_75796930.113.5e-01Click!
Foxp2mm10_v2_chr6_+_15185203_151852440.113.5e-01Click!


Activity profile for motif Foxp2_Foxp3.

activity profile for motif Foxp2_Foxp3


Sorted Z-values histogram for motif Foxp2_Foxp3

Sorted Z-values for motif Foxp2_Foxp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxp2_Foxp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_66386292 12.410 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr8_-_84773381 5.805 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr11_+_3332426 5.420 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr4_+_144892813 5.313 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr2_+_136713444 5.108 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25

chr10_+_29211637 5.085 ENSMUST00000092627.4
 9330159F19Rik
RIKEN cDNA 9330159F19 gene
chr18_+_69344503 4.653 ENSMUST00000114985.3
 Tcf4
transcription factor 4
chr10_+_60106452 4.574 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr15_-_58214882 4.416 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr4_+_144893077 4.360 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr1_+_66386968 4.259 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr6_-_148444336 4.259 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr7_+_82175156 4.027 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3
chr19_+_4855129 3.956 ENSMUST00000119694.1
 Ctsf
cathepsin F
chr4_-_87806296 3.950 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr4_+_144893127 3.770 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr12_-_100725028 3.621 ENSMUST00000043599.6
 Rps6ka5
ribosomal protein S6 kinase, polypeptide 5
chr2_+_28641227 3.514 ENSMUST00000028155.5
ENSMUST00000113869.1
ENSMUST00000113867.2
 Tsc1


tuberous sclerosis 1


chr16_-_4880284 3.293 ENSMUST00000037843.6
 Ubald1
UBA-like domain containing 1
chr13_-_93499803 3.261 ENSMUST00000065537.7
 Jmy
junction-mediating and regulatory protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 232 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 13.4 GO:0042572 retinol metabolic process(GO:0042572)
0.7 12.4 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.6 8.7 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.4 8.2 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
1.1 7.7 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
2.3 7.0 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.5 6.6 GO:0070842 aggresome assembly(GO:0070842)
0.6 6.1 GO:0042118 endothelial cell activation(GO:0042118)
0.4 5.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.5 5.4 GO:0007379 segment specification(GO:0007379)
0.1 5.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.8 4.9 GO:0072318 clathrin coat disassembly(GO:0072318)
0.1 4.9 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.4 4.7 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.5 4.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 4.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.5 4.4 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.4 4.4 GO:0097421 liver regeneration(GO:0097421)
1.1 4.3 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.4 4.3 GO:0051764 actin crosslink formation(GO:0051764)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 14.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.4 13.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 12.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 8.3 GO:0016605 PML body(GO:0016605)
0.2 7.0 GO:0035861 site of double-strand break(GO:0035861)
0.2 5.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
1.3 5.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.6 5.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 4.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 4.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 4.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.0 4.2 GO:0044307 dendritic branch(GO:0044307)
0.1 4.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 4.0 GO:0031941 filamentous actin(GO:0031941)
0.0 4.0 GO:0005769 early endosome(GO:0005769)
1.3 3.9 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.2 3.8 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 3.8 GO:0071564 npBAF complex(GO:0071564)
0.0 3.6 GO:0016604 nuclear body(GO:0016604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 13.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.6 12.2 GO:0042287 MHC protein binding(GO:0042287)
0.1 8.1 GO:0017124 SH3 domain binding(GO:0017124)
2.6 7.7 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.7 7.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
1.5 6.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 6.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.3 5.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 5.4 GO:0005509 calcium ion binding(GO:0005509)
0.6 5.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 5.0 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.8 4.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 4.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
1.0 4.0 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 4.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.8 3.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 3.8 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
1.2 3.6 GO:0035175 histone kinase activity (H3-S10 specific)(GO:0035175)
0.2 3.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.8 3.2 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)