Motif ID: Gata3

Z-value: 1.753


Transcription factors associated with Gata3:

Gene SymbolEntrez IDGene Name
Gata3 ENSMUSG00000015619.10 Gata3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata3mm10_v2_chr2_-_9890026_9890035-0.509.6e-06Click!


Activity profile for motif Gata3.

activity profile for motif Gata3


Sorted Z-values histogram for motif Gata3

Sorted Z-values for motif Gata3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_55681257 15.910 ENSMUST00000044767.8
Neurod6
neurogenic differentiation 6
chr11_+_58948890 14.321 ENSMUST00000078267.3
Hist3h2ba
histone cluster 3, H2ba
chr10_-_81472859 13.713 ENSMUST00000147524.1
ENSMUST00000119060.1
Celf5

CUGBP, Elav-like family member 5

chr11_-_98329641 12.814 ENSMUST00000041685.6
Neurod2
neurogenic differentiation 2
chr4_+_9269285 12.510 ENSMUST00000038841.7
Clvs1
clavesin 1
chr3_+_94478831 11.054 ENSMUST00000029784.5
Celf3
CUGBP, Elav-like family member 3
chr2_-_65567465 10.932 ENSMUST00000066432.5
Scn3a
sodium channel, voltage-gated, type III, alpha
chr2_-_65567505 10.851 ENSMUST00000100069.2
Scn3a
sodium channel, voltage-gated, type III, alpha
chr3_+_102010138 10.306 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr2_-_29253001 10.216 ENSMUST00000071201.4
Ntng2
netrin G2
chr7_+_126950837 9.957 ENSMUST00000106332.1
Sez6l2
seizure related 6 homolog like 2
chr4_+_13751297 9.892 ENSMUST00000105566.2
Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_-_132707304 9.795 ENSMUST00000043189.7
Nfasc
neurofascin
chr4_+_43669610 9.182 ENSMUST00000107866.1
Tmem8b
transmembrane protein 8B
chr17_-_91092715 9.127 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I


chr7_+_126950518 9.125 ENSMUST00000106335.1
ENSMUST00000146017.1
Sez6l2

seizure related 6 homolog like 2

chr14_-_55116935 8.816 ENSMUST00000022819.5
Jph4
junctophilin 4
chr8_-_106337987 8.816 ENSMUST00000067512.7
Smpd3
sphingomyelin phosphodiesterase 3, neutral
chr11_-_72489904 8.614 ENSMUST00000045303.3
Spns2
spinster homolog 2
chr7_-_30534180 8.574 ENSMUST00000044338.4
Arhgap33
Rho GTPase activating protein 33

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 392 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 26.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
4.4 21.8 GO:0046684 response to pyrethroid(GO:0046684)
1.0 18.6 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.2 16.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
3.9 15.5 GO:0007412 axon target recognition(GO:0007412)
2.2 15.2 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.2 14.9 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
1.5 14.8 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315)
1.0 14.6 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.3 14.3 GO:0008542 visual learning(GO:0008542)
0.2 14.0 GO:0007612 learning(GO:0007612)
0.1 13.4 GO:0006334 nucleosome assembly(GO:0006334)
2.2 13.1 GO:0032796 uropod organization(GO:0032796)
1.9 13.0 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
2.2 12.9 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
4.3 12.8 GO:2000297 negative regulation of synapse maturation(GO:2000297)
2.5 12.3 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 11.8 GO:0006342 chromatin silencing(GO:0006342)
0.3 11.0 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.4 10.8 GO:0060749 mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 177 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 45.0 GO:0060076 excitatory synapse(GO:0060076)
1.9 30.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.8 25.0 GO:0030673 axolemma(GO:0030673)
0.6 21.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 17.8 GO:0008021 synaptic vesicle(GO:0008021)
0.4 17.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 15.5 GO:0042734 presynaptic membrane(GO:0042734)
0.1 15.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 14.2 GO:0005905 clathrin-coated pit(GO:0005905)
1.5 13.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.5 13.5 GO:0060077 inhibitory synapse(GO:0060077)
0.1 12.9 GO:0055037 recycling endosome(GO:0055037)
0.6 12.8 GO:0001891 phagocytic cup(GO:0001891)
2.3 11.4 GO:0030314 junctional membrane complex(GO:0030314)
0.2 11.3 GO:0030136 clathrin-coated vesicle(GO:0030136)
1.1 11.2 GO:0044327 dendritic spine head(GO:0044327)
1.1 11.1 GO:0045298 tubulin complex(GO:0045298)
1.0 10.9 GO:0031091 platelet alpha granule(GO:0031091)
1.0 10.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
2.4 9.8 GO:0097454 Schwann cell microvillus(GO:0097454)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 235 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 28.8 GO:0031402 sodium ion binding(GO:0031402)
1.0 24.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 17.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.4 17.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.8 17.6 GO:0034185 apolipoprotein binding(GO:0034185)
2.0 15.9 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
1.3 15.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.6 13.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
1.4 12.4 GO:0019534 toxin transporter activity(GO:0019534)
0.5 11.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 11.3 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.5 11.0 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.6 10.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.3 10.4 GO:0017091 AU-rich element binding(GO:0017091)
0.1 10.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.7 10.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
1.3 10.2 GO:0001618 virus receptor activity(GO:0001618)
0.1 9.8 GO:0005267 potassium channel activity(GO:0005267)
0.1 9.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.4 9.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)