Motif ID: Gbx1_Nobox_Alx3

Z-value: 0.576

Transcription factors associated with Gbx1_Nobox_Alx3:

Gene SymbolEntrez IDGene Name
Alx3 ENSMUSG00000014603.1 Alx3
Gbx1 ENSMUSG00000067724.4 Gbx1
Nobox ENSMUSG00000029736.9 Nobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx3mm10_v2_chr3_+_107595031_1075951640.405.2e-04Click!
Gbx1mm10_v2_chr5_-_24527276_245272760.218.5e-02Click!


Activity profile for motif Gbx1_Nobox_Alx3.

activity profile for motif Gbx1_Nobox_Alx3


Sorted Z-values histogram for motif Gbx1_Nobox_Alx3

Sorted Z-values for motif Gbx1_Nobox_Alx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx1_Nobox_Alx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_23415400 4.252 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr2_+_109917639 3.682 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr6_+_125552948 2.950 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr12_+_38780284 2.709 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr5_-_62765618 2.638 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr13_-_102906046 2.625 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr12_+_109545390 2.602 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr13_-_102905740 2.474 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr15_-_11037968 2.447 ENSMUST00000058007.5
 Rxfp3
relaxin family peptide receptor 3
chr12_+_38780817 2.402 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr8_+_121116163 1.994 ENSMUST00000054691.6
 Foxc2
forkhead box C2
chr8_+_23669653 1.868 ENSMUST00000042352.4
 Zmat4
zinc finger, matrin type 4
chr6_+_29853746 1.843 ENSMUST00000064872.6
ENSMUST00000152581.1
ENSMUST00000176265.1
ENSMUST00000154079.1
 Ahcyl2



S-adenosylhomocysteine hydrolase-like 2



chr15_-_37459327 1.752 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr13_+_94083490 1.750 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr15_+_92597104 1.672 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr6_-_124779686 1.641 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr12_+_38781093 1.632 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr12_-_40037387 1.612 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr7_-_45103747 1.564 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.8 GO:0007638 mechanosensory behavior(GO:0007638)
0.5 4.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
1.2 3.7 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 2.8 GO:0030168 platelet activation(GO:0030168)
0.1 2.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 2.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 2.4 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 2.3 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 2.3 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.3 2.1 GO:0015808 L-alanine transport(GO:0015808)
0.0 2.1 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.7 2.0 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278) regulation of vascular wound healing(GO:0061043) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.2 1.7 GO:0019532 oxalate transport(GO:0019532)
0.0 1.6 GO:0019882 antigen processing and presentation(GO:0019882)
0.5 1.5 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.2 1.5 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 1.5 GO:0031017 exocrine pancreas development(GO:0031017)
0.1 1.5 GO:0001553 luteinization(GO:0001553)
0.1 1.5 GO:0006907 pinocytosis(GO:0006907)
0.1 1.5 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.6 3.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 2.5 GO:0000792 heterochromatin(GO:0000792)
0.1 2.1 GO:0071565 nBAF complex(GO:0071565)
0.0 2.1 GO:0005882 intermediate filament(GO:0005882)
0.0 2.0 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.9 GO:0043034 costamere(GO:0043034)
0.0 1.9 GO:0016607 nuclear speck(GO:0016607)
0.0 1.8 GO:0031201 SNARE complex(GO:0031201)
0.0 1.5 GO:0032590 dendrite membrane(GO:0032590)
0.0 1.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.3 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 1.2 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 1.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.1 GO:0097433 dense body(GO:0097433)
0.0 1.1 GO:0031672 A band(GO:0031672)
0.1 1.0 GO:0005915 zonula adherens(GO:0005915)
0.0 1.0 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.9 GO:0033588 Elongator holoenzyme complex(GO:0033588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 5.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 4.9 GO:0000287 magnesium ion binding(GO:0000287)
0.6 4.2 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.3 3.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.5 3.0 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 2.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 2.7 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.1 2.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 2.3 GO:0002039 p53 binding(GO:0002039)
0.3 2.1 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.0 2.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.8 GO:0016594 glycine binding(GO:0016594)
0.0 1.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.8 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.8 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 1.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.5 1.6 GO:0019770 IgG receptor activity(GO:0019770)
0.2 1.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)