Motif ID: Gbx2

Z-value: 0.590


Transcription factors associated with Gbx2:

Gene SymbolEntrez IDGene Name
Gbx2 ENSMUSG00000034486.7 Gbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx2mm10_v2_chr1_-_89933290_899332900.181.3e-01Click!


Activity profile for motif Gbx2.

activity profile for motif Gbx2


Sorted Z-values histogram for motif Gbx2

Sorted Z-values for motif Gbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_59170978 13.153 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr3_-_116129615 9.502 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr14_-_48667508 9.315 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr11_-_79504078 5.984 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr11_+_59306920 5.866 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr12_+_79297345 5.471 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chr18_+_56432116 5.379 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chrX_+_106920618 4.591 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr16_-_22439719 4.566 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr13_-_97747373 4.110 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr7_+_75455534 3.756 ENSMUST00000147005.1
ENSMUST00000166315.1
 Akap13

A kinase (PRKA) anchor protein 13

chr7_-_30664986 3.663 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr2_+_152754156 3.605 ENSMUST00000010020.5
 Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr1_-_128102412 2.995 ENSMUST00000112538.1
ENSMUST00000086614.5
 Zranb3

zinc finger, RAN-binding domain containing 3

chr19_+_23723279 2.330 ENSMUST00000067077.1
 Gm9938
predicted gene 9938
chr3_+_94372794 2.293 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr12_+_111814170 2.219 ENSMUST00000021714.7
 Zfyve21
zinc finger, FYVE domain containing 21
chr3_-_141982224 2.176 ENSMUST00000029948.8
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr16_-_36784924 2.002 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
 Slc15a2


solute carrier family 15 (H+/peptide transporter), member 2


chr16_-_36784784 1.881 ENSMUST00000165531.1
 Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr13_+_23763660 1.843 ENSMUST00000055770.1
 Hist1h1a
histone cluster 1, H1a
chrM_-_14060 1.838 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr11_-_5878207 1.730 ENSMUST00000102922.3
 Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr10_-_95501921 1.661 ENSMUST00000075829.2
 Mrpl42
mitochondrial ribosomal protein L42
chr9_+_96258697 1.598 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chr16_+_44394771 1.330 ENSMUST00000099742.2
 Wdr52
WD repeat domain 52
chr13_-_97747399 1.324 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr12_-_98259416 1.306 ENSMUST00000021390.7
 Galc
galactosylceramidase
chr7_+_28810886 1.242 ENSMUST00000038572.8
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr3_+_152714094 1.150 ENSMUST00000159899.1
ENSMUST00000045029.8
 Pigk

phosphatidylinositol glycan anchor biosynthesis, class K

chr13_+_49544443 1.019 ENSMUST00000177948.1
ENSMUST00000021820.6
 Aspn

asporin

chr7_-_78783026 1.009 ENSMUST00000032841.5
 Mrpl46
mitochondrial ribosomal protein L46
chr1_-_175625580 0.966 ENSMUST00000027810.7
 Fh1
fumarate hydratase 1
chr3_+_96645579 0.922 ENSMUST00000119365.1
ENSMUST00000029744.5
 Itga10

integrin, alpha 10

chr11_-_21370452 0.789 ENSMUST00000102875.4
 Ugp2
UDP-glucose pyrophosphorylase 2
chr4_+_110397661 0.675 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
 Agbl4



ATP/GTP binding protein-like 4



chr11_+_97315716 0.652 ENSMUST00000019026.3
ENSMUST00000132168.1
 Mrpl45

mitochondrial ribosomal protein L45

chrX_-_56598069 0.532 ENSMUST00000059899.2
 Mmgt1
membrane magnesium transporter 1
chr5_-_5266038 0.531 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
 Cdk14


cyclin-dependent kinase 14


chr4_+_110397764 0.393 ENSMUST00000097920.2
ENSMUST00000080744.6
 Agbl4

ATP/GTP binding protein-like 4

chr11_-_45955183 0.386 ENSMUST00000109254.1
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr18_-_67245818 0.363 ENSMUST00000073054.3
 Mppe1
metallophosphoesterase 1
chr17_-_48432723 0.294 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr5_+_115341225 0.283 ENSMUST00000031508.4
 Triap1
TP53 regulated inhibitor of apoptosis 1
chr3_-_89998656 0.266 ENSMUST00000079724.4
 Hax1
HCLS1 associated X-1
chr8_-_21906412 0.263 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr7_+_78783119 0.193 ENSMUST00000032840.4
 Mrps11
mitochondrial ribosomal protein S11
chr5_-_111761697 0.130 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr2_-_73580288 0.103 ENSMUST00000028515.3
 Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr2_-_160619971 0.098 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr1_+_71652837 0.077 ENSMUST00000097699.2
 Apol7d
apolipoprotein L 7d
chr3_-_10331358 0.059 ENSMUST00000065938.8
ENSMUST00000118410.1
 Impa1

inositol (myo)-1(or 4)-monophosphatase 1

chr10_+_128083273 0.032 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.6 13.2 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
1.4 5.5 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
1.0 3.0 GO:0036292 DNA rewinding(GO:0036292)
1.0 3.9 GO:0042938 dipeptide transport(GO:0042938)
0.9 4.6 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.9 9.5 GO:0061032 visceral serous pericardium development(GO:0061032)
0.6 3.8 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.6 3.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 2.2 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.4 2.3 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.3 1.0 GO:0006106 fumarate metabolic process(GO:0006106)
0.3 6.0 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.3 1.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 0.8 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.2 5.9 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.2 1.0 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.2 1.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 1.3 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.2 1.2 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0 0.5 GO:0006824 cobalt ion transport(GO:0006824)
0.0 3.7 GO:0051225 spindle assembly(GO:0051225)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.3 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.3 GO:0080111 DNA demethylation(GO:0080111)
0.0 1.8 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.7 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.0 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.5 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.6 1.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.5 3.7 GO:0070652 HAUS complex(GO:0070652)
0.5 3.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.4 9.5 GO:0002102 podosome(GO:0002102)
0.2 1.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 3.0 GO:0043596 nuclear replication fork(GO:0043596)
0.1 5.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.0 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 1.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 1.2 GO:0045120 pronucleus(GO:0045120)
0.0 6.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.5 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 3.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.9 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 8.5 GO:0030426 growth cone(GO:0030426)
0.0 6.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.1 GO:0005814 centriole(GO:0005814)
0.0 0.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 9.5 GO:0008131 primary amine oxidase activity(GO:0008131)
1.6 13.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.8 5.5 GO:0000150 recombinase activity(GO:0000150)
0.8 3.9 GO:0042895 antibiotic transporter activity(GO:0042895)
0.8 4.6 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.6 2.3 GO:0008142 oxysterol binding(GO:0008142)
0.2 3.0 GO:0036310 annealing helicase activity(GO:0036310)
0.2 2.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 0.9 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.2 3.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.2 3.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 5.9 GO:0005109 frizzled binding(GO:0005109)
0.1 1.2 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 0.3 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 0.8 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.1 0.5 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
0.1 1.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.0 0.3 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 13.9 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.1 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 0.1 GO:0031403 lithium ion binding(GO:0031403)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)
0.0 1.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.5 GO:0030332 cyclin binding(GO:0030332)