Motif ID: Gli1
Z-value: 0.651
Transcription factors associated with Gli1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Gli1 | ENSMUSG00000025407.6 | Gli1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gli1 | mm10_v2_chr10_-_127341583_127341614 | -0.52 | 4.5e-06 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:0035864 | response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865) |
| 1.2 | 3.5 | GO:0045763 | negative regulation of cellular amino acid metabolic process(GO:0045763) |
| 1.1 | 9.7 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 1.1 | 3.2 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.8 | 8.8 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.8 | 3.0 | GO:0019355 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
| 0.7 | 2.1 | GO:0072070 | establishment or maintenance of polarity of embryonic epithelium(GO:0016332) loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236) |
| 0.7 | 4.7 | GO:0032811 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811) |
| 0.6 | 1.9 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980) |
| 0.6 | 3.6 | GO:1900451 | rhythmic synaptic transmission(GO:0060024) terminal button organization(GO:0072553) positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of protein localization to synapse(GO:1902474) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969) |
| 0.6 | 1.7 | GO:0071336 | lung growth(GO:0060437) positive regulation of fat cell proliferation(GO:0070346) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) |
| 0.5 | 2.1 | GO:0051708 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 0.5 | 5.7 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 0.5 | 1.9 | GO:0046898 | response to cycloheximide(GO:0046898) |
| 0.5 | 1.8 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.4 | 2.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.4 | 6.3 | GO:1902993 | positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993) |
| 0.4 | 2.4 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.4 | 2.7 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
| 0.4 | 1.1 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.4 | 1.1 | GO:2000832 | protein-chromophore linkage(GO:0018298) negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850) |
| 0.4 | 2.8 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.4 | 1.8 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.2 | 1.9 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.2 | 3.3 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.2 | 3.7 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.2 | 1.5 | GO:0071361 | autophagic cell death(GO:0048102) cellular response to ethanol(GO:0071361) |
| 0.2 | 1.0 | GO:0030242 | pexophagy(GO:0030242) |
| 0.2 | 1.2 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 0.2 | 2.4 | GO:0042711 | maternal behavior(GO:0042711) |
| 0.2 | 1.0 | GO:0090164 | asymmetric Golgi ribbon formation(GO:0090164) |
| 0.2 | 1.3 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
| 0.2 | 0.5 | GO:0070375 | ERK5 cascade(GO:0070375) |
| 0.2 | 5.0 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.2 | 0.5 | GO:0070124 | mitochondrial translational initiation(GO:0070124) |
| 0.2 | 2.5 | GO:0051481 | negative regulation of cytosolic calcium ion concentration(GO:0051481) |
| 0.2 | 2.0 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.1 | 1.2 | GO:0070544 | histone H3-K36 demethylation(GO:0070544) |
| 0.1 | 0.4 | GO:0048859 | formation of anatomical boundary(GO:0048859) |
| 0.1 | 2.3 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 0.6 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
| 0.1 | 1.3 | GO:0097119 | postsynaptic density protein 95 clustering(GO:0097119) |
| 0.1 | 0.8 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.1 | 5.6 | GO:0003407 | neural retina development(GO:0003407) |
| 0.1 | 1.7 | GO:0001553 | luteinization(GO:0001553) |
| 0.1 | 1.8 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.1 | 0.8 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
| 0.1 | 3.6 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.1 | 0.4 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.1 | 0.4 | GO:0050912 | detection of chemical stimulus involved in sensory perception(GO:0050907) detection of chemical stimulus involved in sensory perception of taste(GO:0050912) |
| 0.1 | 0.7 | GO:0035898 | parathyroid hormone secretion(GO:0035898) |
| 0.1 | 0.4 | GO:1904721 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.1 | 2.9 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.1 | 0.7 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.1 | 0.2 | GO:0006667 | sphinganine metabolic process(GO:0006667) |
| 0.1 | 0.3 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
| 0.1 | 0.9 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.1 | 0.6 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.1 | 0.4 | GO:0006361 | transcription initiation from RNA polymerase I promoter(GO:0006361) |
| 0.1 | 2.0 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.1 | 0.6 | GO:2000465 | regulation of glycogen (starch) synthase activity(GO:2000465) |
| 0.1 | 0.3 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.0 | 0.3 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.0 | 0.9 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.0 | 0.7 | GO:0045792 | negative regulation of cell size(GO:0045792) |
| 0.0 | 0.5 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.4 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 1.5 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.0 | 2.1 | GO:0035383 | acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383) |
| 0.0 | 1.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.8 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.0 | 3.6 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.0 | 0.1 | GO:0045019 | negative regulation of nitric oxide biosynthetic process(GO:0045019) negative regulation of nitric oxide metabolic process(GO:1904406) |
| 0.0 | 2.6 | GO:0008654 | phospholipid biosynthetic process(GO:0008654) |
| 0.0 | 0.3 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.0 | 0.9 | GO:0032024 | positive regulation of insulin secretion(GO:0032024) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 4.7 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.9 | 2.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.7 | 2.1 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.5 | 9.7 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.4 | 8.8 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.3 | 2.1 | GO:0042825 | TAP complex(GO:0042825) |
| 0.3 | 0.9 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.2 | 1.9 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.2 | 1.2 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.2 | 3.5 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.2 | 1.8 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.2 | 5.1 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 2.4 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 5.2 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.1 | 5.6 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 1.9 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
| 0.1 | 0.4 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.1 | 2.3 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 0.4 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.1 | 0.8 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.1 | 0.8 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.1 | 3.3 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 0.3 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.1 | 0.7 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.2 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.0 | 2.0 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 3.2 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 1.9 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 3.3 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 8.6 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.0 | 7.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 2.7 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 1.0 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 1.7 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.8 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 1.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.4 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 1.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 3.0 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 1.4 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 1.6 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.3 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 1.5 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.5 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 2.9 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.8 | 3.3 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.8 | 3.1 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 0.8 | 4.7 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.8 | 3.0 | GO:0004515 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515) |
| 0.7 | 2.1 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.7 | 2.1 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.5 | 9.7 | GO:0004890 | GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917) |
| 0.5 | 2.1 | GO:1902379 | chemoattractant activity involved in axon guidance(GO:1902379) |
| 0.5 | 2.1 | GO:0023029 | peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980) |
| 0.5 | 2.4 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.5 | 1.9 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.4 | 1.7 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.4 | 3.2 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.4 | 1.1 | GO:0009881 | photoreceptor activity(GO:0009881) |
| 0.3 | 8.8 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.3 | 2.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.3 | 1.9 | GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) |
| 0.3 | 3.5 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.2 | 1.9 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.2 | 2.5 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.2 | 3.6 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.2 | 1.4 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.2 | 0.6 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.1 | 0.4 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.1 | 0.9 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.1 | 1.8 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 1.3 | GO:0048185 | activin binding(GO:0048185) |
| 0.1 | 1.7 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.1 | 0.5 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.1 | 0.4 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.1 | 6.7 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.1 | 0.4 | GO:0004724 | magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) |
| 0.1 | 5.6 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.1 | 7.6 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.1 | 2.0 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 0.2 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) |
| 0.1 | 0.8 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.1 | 0.4 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.1 | 2.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 0.9 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 1.4 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.4 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.0 | 2.0 | GO:0004120 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715) |
| 0.0 | 0.5 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.0 | 0.7 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 1.9 | GO:0016209 | antioxidant activity(GO:0016209) |
| 0.0 | 0.1 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 1.5 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 1.2 | GO:0044824 | integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824) |
| 0.0 | 0.8 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.8 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 1.0 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 0.5 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 0.4 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.0 | 1.1 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.7 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 0.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.3 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.7 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 0.5 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 0.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
