Motif ID: Gli1

Z-value: 0.651


Transcription factors associated with Gli1:

Gene SymbolEntrez IDGene Name
Gli1 ENSMUSG00000025407.6 Gli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli1mm10_v2_chr10_-_127341583_127341614-0.524.5e-06Click!


Activity profile for motif Gli1.

activity profile for motif Gli1


Sorted Z-values histogram for motif Gli1

Sorted Z-values for motif Gli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 172 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_54954728 5.553 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr11_-_42000284 5.019 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr11_-_42000532 3.946 ENSMUST00000070735.3
 Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr11_-_119547744 3.807 ENSMUST00000026670.4
 Nptx1
neuronal pentraxin 1
chr1_-_56972437 3.696 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr1_-_133801031 3.539 ENSMUST00000143567.1
 Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr2_-_54085542 3.389 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr15_-_95528228 3.383 ENSMUST00000075275.2
 Nell2
NEL-like 2
chr18_-_43373248 3.296 ENSMUST00000118043.1
 Dpysl3
dihydropyrimidinase-like 3
chr10_-_64090265 3.293 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr12_-_81333129 3.165 ENSMUST00000085238.6
ENSMUST00000182208.1
 Slc8a3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr1_+_152954966 3.001 ENSMUST00000043313.8
 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr17_+_37045963 2.983 ENSMUST00000025338.9
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr10_-_64090241 2.978 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr15_-_78544345 2.863 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr9_+_50752758 2.551 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr17_-_24209377 2.500 ENSMUST00000024931.4
 Ntn3
netrin 3
chr5_+_30588078 2.466 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr4_-_68954351 2.437 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr12_+_44328882 2.377 ENSMUST00000020939.8
ENSMUST00000110748.2
 Nrcam

neuron-glia-CAM-related cell adhesion molecule


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 9.7 GO:0071420 cellular response to histamine(GO:0071420)
0.8 8.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 6.3 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.5 5.7 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 5.6 GO:0003407 neural retina development(GO:0003407)
0.2 5.0 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.7 4.7 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
1.3 3.8 GO:0035864 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.2 3.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 3.6 GO:1900451 rhythmic synaptic transmission(GO:0060024) terminal button organization(GO:0072553) positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of protein localization to synapse(GO:1902474) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.1 3.6 GO:0007520 myoblast fusion(GO:0007520)
0.0 3.6 GO:0048813 dendrite morphogenesis(GO:0048813)
1.2 3.5 GO:0045763 negative regulation of cellular amino acid metabolic process(GO:0045763)
0.2 3.3 GO:0051764 actin crosslink formation(GO:0051764)
1.1 3.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.8 3.0 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 2.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.4 2.8 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.4 2.7 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.4 2.6 GO:0007021 tubulin complex assembly(GO:0007021)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.4 8.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 8.6 GO:0060076 excitatory synapse(GO:0060076)
0.0 7.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 5.6 GO:0044295 axonal growth cone(GO:0044295)
0.1 5.2 GO:0060170 ciliary membrane(GO:0060170)
0.2 5.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.9 4.7 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.2 3.5 GO:0097228 sperm principal piece(GO:0097228)
0.1 3.3 GO:0031941 filamentous actin(GO:0031941)
0.0 3.3 GO:0043204 perikaryon(GO:0043204)
0.0 3.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 3.0 GO:0005770 late endosome(GO:0005770)
0.0 2.7 GO:0030175 filopodium(GO:0030175)
0.9 2.6 GO:0097512 cardiac myofibril(GO:0097512)
0.1 2.4 GO:0043194 axon initial segment(GO:0043194)
0.1 2.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.7 2.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.3 2.1 GO:0042825 TAP complex(GO:0042825)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.7 GO:0004890 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
0.3 8.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 7.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 6.7 GO:0005262 calcium channel activity(GO:0005262)
0.1 5.6 GO:0005080 protein kinase C binding(GO:0005080)
0.8 4.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 3.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 3.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.8 3.3 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.4 3.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.8 3.1 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.8 3.0 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
1.0 2.9 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 2.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 2.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 2.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.5 2.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.7 2.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.7 2.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.5 2.1 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)