Motif ID: Gli3_Zic1

Z-value: 1.075

Transcription factors associated with Gli3_Zic1:

Gene SymbolEntrez IDGene Name
Gli3 ENSMUSG00000021318.9 Gli3
Zic1 ENSMUSG00000032368.8 Zic1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli3mm10_v2_chr13_+_15463837_15463980-0.515.6e-06Click!
Zic1mm10_v2_chr9_-_91365778_91365815-0.263.1e-02Click!


Activity profile for motif Gli3_Zic1.

activity profile for motif Gli3_Zic1


Sorted Z-values histogram for motif Gli3_Zic1

Sorted Z-values for motif Gli3_Zic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli3_Zic1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_50752758 9.789 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr16_+_91269759 8.812 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr2_-_29253001 7.567 ENSMUST00000071201.4
 Ntng2
netrin G2
chr4_-_148130678 7.490 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr8_+_70501116 6.874 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr11_-_42000284 6.256 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr6_-_101377897 5.942 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr8_-_105966038 5.655 ENSMUST00000116429.2
ENSMUST00000034370.9
 Slc12a4

solute carrier family 12, member 4

chr11_-_42000532 5.436 ENSMUST00000070735.3
 Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr1_-_133801031 5.269 ENSMUST00000143567.1
 Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr7_+_5057161 5.257 ENSMUST00000045543.5
 Ccdc106
coiled-coil domain containing 106
chr7_+_5056856 5.238 ENSMUST00000131368.1
ENSMUST00000123956.1
 Ccdc106

coiled-coil domain containing 106

chrX_+_101299143 5.197 ENSMUST00000118111.1
ENSMUST00000130555.1
ENSMUST00000151528.1
 Nlgn3


neuroligin 3


chr4_+_124657646 5.071 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr6_+_86195214 5.052 ENSMUST00000032066.9
 Tgfa
transforming growth factor alpha
chr4_-_68954351 5.041 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr6_-_113531575 4.899 ENSMUST00000032425.5
 Emc3
ER membrane protein complex subunit 3
chr15_-_95528228 4.840 ENSMUST00000075275.2
 Nell2
NEL-like 2
chr6_+_17463749 4.821 ENSMUST00000115443.1
 Met
met proto-oncogene
chrX_+_101299207 4.731 ENSMUST00000065858.2
 Nlgn3
neuroligin 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 195 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 20.6 GO:0071420 cellular response to histamine(GO:0071420)
1.4 12.3 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
1.8 10.8 GO:0060024 rhythmic synaptic transmission(GO:0060024)
1.6 9.8 GO:0007021 tubulin complex assembly(GO:0007021)
0.7 7.5 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.4 7.5 GO:0021516 dorsal spinal cord development(GO:0021516)
1.0 7.2 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
1.1 6.8 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.4 6.6 GO:0001553 luteinization(GO:0001553)
2.2 6.5 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.2 6.1 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.1 6.1 GO:0048663 neuron fate commitment(GO:0048663)
0.5 5.7 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 5.7 GO:0006813 potassium ion transport(GO:0006813)
1.9 5.6 GO:0016191 synaptic vesicle uncoating(GO:0016191) regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
0.1 5.6 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.1 5.5 GO:0007528 neuromuscular junction development(GO:0007528)
0.5 5.4 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
1.8 5.3 GO:0045763 regulation of arginine metabolic process(GO:0000821) negative regulation of cellular amino acid metabolic process(GO:0045763)
0.5 5.1 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 20.6 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.5 11.7 GO:0060077 inhibitory synapse(GO:0060077)
0.0 11.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 10.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 10.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 10.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.3 10.0 GO:0030673 axolemma(GO:0030673)
3.2 9.5 GO:0097512 cardiac myofibril(GO:0097512)
0.2 7.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 7.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
1.4 7.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
2.3 6.9 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 6.2 GO:0031594 neuromuscular junction(GO:0031594)
0.6 5.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 5.8 GO:0030175 filopodium(GO:0030175)
0.5 5.7 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.3 5.6 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.3 5.3 GO:0097228 sperm principal piece(GO:0097228)
0.4 4.9 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 4.9 GO:0005905 clathrin-coated pit(GO:0005905)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 20.6 GO:0004890 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
2.7 10.8 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.6 9.9 GO:0042043 neurexin family protein binding(GO:0042043)
1.2 7.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.0 6.9 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.8 6.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 6.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.9 6.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.3 6.2 GO:0015026 coreceptor activity(GO:0015026)
1.0 5.9 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.4 5.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.9 5.7 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.6 5.7 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.8 5.6 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.1 5.6 GO:0005262 calcium channel activity(GO:0005262)
0.2 5.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 5.3 GO:0030276 clathrin binding(GO:0030276)
0.0 5.0 GO:0005516 calmodulin binding(GO:0005516)
0.2 4.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 4.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)