Motif ID: Glis2

Z-value: 0.910


Transcription factors associated with Glis2:

Gene SymbolEntrez IDGene Name
Glis2 ENSMUSG00000014303.7 Glis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis2mm10_v2_chr16_+_4594683_45947350.253.4e-02Click!


Activity profile for motif Glis2.

activity profile for motif Glis2


Sorted Z-values histogram for motif Glis2

Sorted Z-values for motif Glis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis2

PNG image of the network

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Top targets:


Showing 1 to 20 of 189 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 15.265 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr7_-_103843154 8.484 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr19_+_7268296 6.217 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr6_-_48840988 5.790 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr11_+_101468164 5.095 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr4_+_109978004 4.999 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr2_-_54085542 4.622 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr4_-_58499398 4.284 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr5_+_136083916 4.183 ENSMUST00000042135.7
 Rasa4
RAS p21 protein activator 4
chr6_-_48841098 4.181 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr17_-_56830916 4.166 ENSMUST00000002444.7
ENSMUST00000086801.5
 Rfx2

regulatory factor X, 2 (influences HLA class II expression)

chr14_+_55854115 4.163 ENSMUST00000168479.1
 Nynrin
NYN domain and retroviral integrase containing
chr5_+_136084022 4.036 ENSMUST00000100570.3
 Rasa4
RAS p21 protein activator 4
chr6_-_48841373 4.035 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr6_+_120666388 3.759 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr6_+_48841476 3.445 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr6_+_48841633 3.398 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr2_+_4976113 3.275 ENSMUST00000167607.1
ENSMUST00000115010.2
 Ucma

upper zone of growth plate and cartilage matrix associated

chr11_+_72042455 3.133 ENSMUST00000021164.3
 Fam64a
family with sequence similarity 64, member A
chr17_+_80127447 2.999 ENSMUST00000039205.4
 Galm
galactose mutarotase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 20.8 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.6 20.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
1.7 8.5 GO:0015671 oxygen transport(GO:0015671)
0.2 8.2 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.6 6.2 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
1.1 5.4 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) positive regulation of cell fate specification(GO:0042660)
0.5 5.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 5.0 GO:0021796 cerebral cortex regionalization(GO:0021796)
1.1 4.6 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 4.6 GO:0007050 cell cycle arrest(GO:0007050)
1.1 4.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.5 4.2 GO:0015074 DNA integration(GO:0015074)
0.4 4.2 GO:0001675 acrosome assembly(GO:0001675)
0.1 3.9 GO:0043303 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.5 3.8 GO:0001842 neural fold formation(GO:0001842)
0.7 3.6 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.4 3.6 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040) negative regulation of protein folding(GO:1903333)
0.6 3.5 GO:0032796 uropod organization(GO:0032796)
0.1 3.5 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.6 3.0 GO:0040032 post-embryonic body morphogenesis(GO:0040032)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 22.8 GO:0005654 nucleoplasm(GO:0005654)
0.0 8.6 GO:0005667 transcription factor complex(GO:0005667)
1.1 8.5 GO:0005833 hemoglobin complex(GO:0005833)
0.6 8.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 7.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.8 5.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.4 5.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 5.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 5.0 GO:0016235 aggresome(GO:0016235)
0.1 4.9 GO:0005882 intermediate filament(GO:0005882)
0.0 4.8 GO:0005769 early endosome(GO:0005769)
0.0 4.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 4.3 GO:0043198 dendritic shaft(GO:0043198)
0.9 3.8 GO:0090537 CERF complex(GO:0090537)
0.1 3.5 GO:0001891 phagocytic cup(GO:0001891)
0.9 2.7 GO:0005577 fibrinogen complex(GO:0005577)
0.8 2.4 GO:0044194 cytolytic granule(GO:0044194)
0.3 2.1 GO:0097452 GAIT complex(GO:0097452)
0.0 2.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 15.3 GO:0019841 retinol binding(GO:0019841)
2.1 8.5 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.0 6.8 GO:0047485 protein N-terminus binding(GO:0047485)
0.8 5.7 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.5 5.4 GO:0003680 AT DNA binding(GO:0003680)
0.9 5.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.5 4.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 4.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 4.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 4.6 GO:0001047 core promoter binding(GO:0001047)
0.7 4.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
1.2 3.6 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.3 3.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 3.3 GO:0005096 GTPase activator activity(GO:0005096)
0.5 3.0 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 3.0 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.7 2.8 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.1 2.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.9 2.7 GO:0070052 collagen V binding(GO:0070052)
0.5 2.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)