Motif ID: Gmeb1

Z-value: 0.678


Transcription factors associated with Gmeb1:

Gene SymbolEntrez IDGene Name
Gmeb1 ENSMUSG00000028901.7 Gmeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gmeb1mm10_v2_chr4_-_132261596_1322616220.405.8e-04Click!


Activity profile for motif Gmeb1.

activity profile for motif Gmeb1


Sorted Z-values histogram for motif Gmeb1

Sorted Z-values for motif Gmeb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gmeb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_113531675 8.564 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr1_+_175880775 8.184 ENSMUST00000039725.6
 Exo1
exonuclease 1
chr7_-_19310035 7.585 ENSMUST00000003640.2
 Fosb
FBJ osteosarcoma oncogene B
chr2_-_157007039 7.486 ENSMUST00000103129.2
ENSMUST00000103130.1
 Dsn1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr3_+_40800054 6.879 ENSMUST00000168287.1
 Plk4
polo-like kinase 4
chr15_+_99074968 6.819 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr2_-_157007015 6.801 ENSMUST00000146413.1
 Dsn1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
chr8_-_94918012 6.489 ENSMUST00000077955.5
 Ccdc102a
coiled-coil domain containing 102A
chr3_+_40800013 6.182 ENSMUST00000026858.5
ENSMUST00000170825.1
 Plk4

polo-like kinase 4

chr3_+_127553462 4.984 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr19_+_43612299 4.712 ENSMUST00000057178.9
 Nkx2-3
NK2 homeobox 3
chr17_+_23679363 4.300 ENSMUST00000024699.2
 Cldn6
claudin 6
chr11_-_100822525 4.292 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chrX_+_112311334 4.217 ENSMUST00000026599.3
ENSMUST00000113415.1
 Apool

apolipoprotein O-like

chr11_-_40733373 3.974 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr8_-_45333189 3.558 ENSMUST00000095328.4
 Cyp4v3
cytochrome P450, family 4, subfamily v, polypeptide 3
chr13_-_53473074 3.549 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr11_+_86544982 3.388 ENSMUST00000108030.2
ENSMUST00000020821.3
ENSMUST00000069503.6
ENSMUST00000167178.2
 Tubd1



tubulin, delta 1



chr3_+_138143429 3.228 ENSMUST00000040321.6
 Trmt10a
tRNA methyltransferase 10A
chr3_-_138143352 3.028 ENSMUST00000098580.2
 Mttp
microsomal triglyceride transfer protein
chr2_+_75659253 2.899 ENSMUST00000111964.1
ENSMUST00000111962.1
ENSMUST00000111961.1
ENSMUST00000164947.2
ENSMUST00000090792.4
 Hnrnpa3




heterogeneous nuclear ribonucleoprotein A3




chr17_+_84511832 2.851 ENSMUST00000047206.5
 Plekhh2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr3_+_138143483 2.688 ENSMUST00000162864.1
 Trmt10a
tRNA methyltransferase 10A
chr11_+_53770458 2.388 ENSMUST00000138913.1
ENSMUST00000123376.1
ENSMUST00000019043.6
ENSMUST00000133291.1
 Irf1



interferon regulatory factor 1



chr7_+_35397046 2.111 ENSMUST00000079414.5
 Cep89
centrosomal protein 89
chr11_+_40733639 2.079 ENSMUST00000020578.4
 Nudcd2
NudC domain containing 2
chr15_-_58135047 1.892 ENSMUST00000038194.3
 Atad2
ATPase family, AAA domain containing 2
chr1_+_95313607 1.828 ENSMUST00000059975.6
 Fam174a
family with sequence similarity 174, member A
chr4_-_135353126 1.747 ENSMUST00000030613.4
ENSMUST00000131373.1
 Srrm1

serine/arginine repetitive matrix 1

chr15_-_81399594 1.734 ENSMUST00000023039.8
 St13
suppression of tumorigenicity 13
chr8_-_25016901 1.732 ENSMUST00000084035.5
 Adam9
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr4_+_128727585 1.673 ENSMUST00000106079.3
ENSMUST00000133439.1
 Phc2

polyhomeotic-like 2 (Drosophila)

chr8_-_25016743 1.558 ENSMUST00000084032.5
 Adam9
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr4_-_135353164 1.524 ENSMUST00000084846.5
ENSMUST00000136342.2
ENSMUST00000105861.1
 Srrm1


serine/arginine repetitive matrix 1


chr4_+_55350043 1.299 ENSMUST00000030134.8
 Rad23b
RAD23b homolog (S. cerevisiae)
chr12_-_31654767 1.297 ENSMUST00000020977.2
 Dus4l
dihydrouridine synthase 4-like (S. cerevisiae)
chr3_+_95434386 1.273 ENSMUST00000102749.4
ENSMUST00000090804.5
ENSMUST00000107161.1
ENSMUST00000107160.1
ENSMUST00000015666.10
 Arnt




aryl hydrocarbon receptor nuclear translocator




chr1_-_191397026 1.192 ENSMUST00000067976.3
 Ppp2r5a
protein phosphatase 2, regulatory subunit B (B56), alpha isoform
chr11_+_69914179 1.179 ENSMUST00000057884.5
 Gps2
G protein pathway suppressor 2
chr11_-_97782409 1.148 ENSMUST00000103146.4
 Rpl23
ribosomal protein L23
chr1_+_82316452 1.122 ENSMUST00000027322.7
 Rhbdd1
rhomboid domain containing 1
chr8_-_123949201 1.082 ENSMUST00000044795.7
 Nup133
nucleoporin 133
chr5_-_31291026 0.928 ENSMUST00000041565.7
 Ift172
intraflagellar transport 172
chr7_+_101663705 0.871 ENSMUST00000106998.1
 Clpb
ClpB caseinolytic peptidase B
chr17_-_56626872 0.856 ENSMUST00000047226.8
 Lonp1
lon peptidase 1, mitochondrial
chr14_+_32085804 0.823 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
 Oxnad1


oxidoreductase NAD-binding domain containing 1


chr16_+_49699198 0.813 ENSMUST00000046777.4
ENSMUST00000142682.1
 Ift57

intraflagellar transport 57

chr3_-_127553233 0.803 ENSMUST00000029588.5
 Larp7
La ribonucleoprotein domain family, member 7
chr16_+_35022394 0.762 ENSMUST00000061156.8
 Ptplb
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
chr10_+_96616998 0.749 ENSMUST00000038377.7
 Btg1
B cell translocation gene 1, anti-proliferative
chr4_-_126202583 0.721 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
 Thrap3


thyroid hormone receptor associated protein 3


chr15_-_81400043 0.697 ENSMUST00000172107.1
ENSMUST00000169204.1
ENSMUST00000163382.1
 St13


suppression of tumorigenicity 13


chr16_+_20548577 0.688 ENSMUST00000003319.5
 Abcf3
ATP-binding cassette, sub-family F (GCN20), member 3
chr9_-_48495321 0.669 ENSMUST00000170000.2
 Rbm7
RNA binding motif protein 7
chr11_-_113751309 0.659 ENSMUST00000106616.1
 Cdc42ep4
CDC42 effector protein (Rho GTPase binding) 4
chr6_+_29348069 0.566 ENSMUST00000173216.1
ENSMUST00000031779.10
ENSMUST00000090481.7
 Calu


calumenin


chr11_-_97782377 0.534 ENSMUST00000128801.1
 Rpl23
ribosomal protein L23
chr11_-_6626030 0.511 ENSMUST00000000394.7
ENSMUST00000136682.1
 Tbrg4

transforming growth factor beta regulated gene 4

chr4_-_126202757 0.483 ENSMUST00000080919.5
 Thrap3
thyroid hormone receptor associated protein 3
chr19_-_40588374 0.404 ENSMUST00000175932.1
ENSMUST00000176955.1
ENSMUST00000149476.2
 Aldh18a1


aldehyde dehydrogenase 18 family, member A1


chr7_+_101663633 0.389 ENSMUST00000001884.7
 Clpb
ClpB caseinolytic peptidase B
chr11_+_97315716 0.376 ENSMUST00000019026.3
ENSMUST00000132168.1
 Mrpl45

mitochondrial ribosomal protein L45

chr19_-_24477356 0.280 ENSMUST00000099556.1
 Fam122a
family with sequence similarity 122, member A
chr19_-_40588338 0.268 ENSMUST00000176939.1
 Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr15_+_102073773 0.237 ENSMUST00000169681.1
 Eif4b
eukaryotic translation initiation factor 4B
chr15_-_99087817 0.233 ENSMUST00000064462.3
 C1ql4
complement component 1, q subcomponent-like 4
chr4_-_72200833 0.217 ENSMUST00000102848.2
ENSMUST00000072695.6
ENSMUST00000107337.1
ENSMUST00000074216.7
 Tle1



transducin-like enhancer of split 1, homolog of Drosophila E(spl)



chr10_-_81378459 0.117 ENSMUST00000140901.1
 Fzr1
fizzy/cell division cycle 20 related 1 (Drosophila)
chr5_+_113772748 0.076 ENSMUST00000026937.5
ENSMUST00000112311.1
ENSMUST00000112312.1
 Iscu


IscU iron-sulfur cluster scaffold homolog (E. coli)


chr12_+_4917376 0.073 ENSMUST00000045664.5
 Atad2b
ATPase family, AAA domain containing 2B
chr9_+_48495345 0.041 ENSMUST00000048824.7
 Gm5617
predicted gene 5617
chr19_-_40588453 0.027 ENSMUST00000025979.6
 Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chrX_+_150588223 0.008 ENSMUST00000153221.1
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr10_+_80798652 0.004 ENSMUST00000151928.1
 Sf3a2
splicing factor 3a, subunit 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 13.1 GO:0046601 positive regulation of centriole replication(GO:0046601)
1.4 4.3 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
1.2 8.6 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
1.2 3.5 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
1.1 3.3 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.8 8.2 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.8 2.4 GO:2000564 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.8 4.7 GO:0002317 plasma cell differentiation(GO:0002317)
0.6 3.0 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.4 1.3 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.4 1.1 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.3 2.4 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.3 4.2 GO:0042407 cristae formation(GO:0042407)
0.2 0.7 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.2 5.9 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.2 0.7 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.2 2.0 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 1.2 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.1 7.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 1.1 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.1 1.3 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.1 1.2 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of JNK cascade(GO:0046329) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.1 0.8 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.1 1.7 GO:0060972 left/right pattern formation(GO:0060972)
0.1 2.9 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.1 0.7 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 1.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.9 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.1 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 2.1 GO:0035058 nonmotile primary cilium assembly(GO:0035058)
0.0 3.6 GO:0019395 fatty acid oxidation(GO:0019395)
0.0 1.3 GO:0034605 cellular response to heat(GO:0034605)
0.0 9.9 GO:0007059 chromosome segregation(GO:0007059)
0.0 2.9 GO:0051028 mRNA transport(GO:0051028)
0.0 4.3 GO:0045216 cell-cell junction organization(GO:0045216)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.2 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.2 GO:2000811 negative regulation of anoikis(GO:2000811)
0.0 4.2 GO:0007283 spermatogenesis(GO:0007283)
0.0 2.6 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 1.3 GO:0008033 tRNA processing(GO:0008033)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 14.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
1.6 13.1 GO:0098536 deuterosome(GO:0098536)
0.5 4.2 GO:0061617 MICOS complex(GO:0061617)
0.3 1.3 GO:0071942 XPC complex(GO:0071942)
0.2 3.3 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.2 4.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 3.0 GO:0031528 microvillus membrane(GO:0031528)
0.2 2.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 2.1 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 6.5 GO:0016459 myosin complex(GO:0016459)
0.1 1.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 1.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.7 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 8.6 GO:0000793 condensed chromosome(GO:0000793)
0.1 1.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 2.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 3.3 GO:0005681 spliceosomal complex(GO:0005681)
0.0 1.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 5.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.2 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.7 2.9 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.6 9.4 GO:0070182 DNA polymerase binding(GO:0070182)
0.4 1.3 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.4 3.6 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
0.3 2.4 GO:0032564 dATP binding(GO:0032564)
0.3 1.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.2 0.7 GO:0017084 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
0.2 4.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 4.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 3.0 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 1.7 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 3.3 GO:0043236 laminin binding(GO:0043236)
0.1 5.9 GO:0000049 tRNA binding(GO:0000049)
0.1 0.8 GO:0071949 FAD binding(GO:0071949)
0.1 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 6.5 GO:0003774 motor activity(GO:0003774)
0.0 3.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 1.2 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 10.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.3 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 2.1 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.0 7.2 GO:0004674 protein serine/threonine kinase activity(GO:0004674)