Motif ID: Grhl1

Z-value: 0.388


Transcription factors associated with Grhl1:

Gene SymbolEntrez IDGene Name
Grhl1 ENSMUSG00000020656.9 Grhl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Grhl1mm10_v2_chr12_+_24572276_245723080.291.5e-02Click!


Activity profile for motif Grhl1.

activity profile for motif Grhl1


Sorted Z-values histogram for motif Grhl1

Sorted Z-values for motif Grhl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Grhl1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_87635974 4.075 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chrX_+_100730178 3.534 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr2_-_105399286 3.322 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr18_+_56432116 3.295 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr8_+_80494032 2.936 ENSMUST00000063359.6
 Gypa
glycophorin A
chr16_-_26989974 1.949 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr2_+_172550761 1.889 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr19_-_18631754 1.511 ENSMUST00000025631.6
 Ostf1
osteoclast stimulating factor 1
chr13_+_8885501 1.511 ENSMUST00000169314.2
 Idi1
isopentenyl-diphosphate delta isomerase
chr4_+_141242850 1.494 ENSMUST00000138096.1
ENSMUST00000006618.2
ENSMUST00000125392.1
 Arhgef19


Rho guanine nucleotide exchange factor (GEF) 19


chr1_+_135818593 1.456 ENSMUST00000038760.8
 Lad1
ladinin
chr8_-_71381907 1.432 ENSMUST00000002466.8
 Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr6_+_128438757 1.275 ENSMUST00000144745.1
 Gm10069
predicted gene 10069
chr10_-_128565827 1.252 ENSMUST00000131728.1
ENSMUST00000026425.6
 Pa2g4

proliferation-associated 2G4

chr4_+_109676568 1.193 ENSMUST00000102724.4
 Faf1
Fas-associated factor 1
chr10_-_79533750 1.100 ENSMUST00000166804.1
ENSMUST00000063879.5
 Ppap2c

phosphatidic acid phosphatase type 2C

chr14_+_63943666 1.088 ENSMUST00000079652.5
 Sox7
SRY-box containing gene 7
chr2_-_151973387 0.990 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chr7_+_101321703 0.957 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
 Stard10




START domain containing 10




chr14_+_75136326 0.893 ENSMUST00000145303.1
 Lcp1
lymphocyte cytosolic protein 1
chrX_-_38456407 0.801 ENSMUST00000074913.5
ENSMUST00000016678.7
ENSMUST00000061755.8
 Lamp2


lysosomal-associated membrane protein 2


chr14_+_79481164 0.779 ENSMUST00000040131.5
 Elf1
E74-like factor 1
chr12_+_76417598 0.779 ENSMUST00000063977.7
 Ppp1r36
protein phosphatase 1, regulatory subunit 36
chr17_-_56005566 0.747 ENSMUST00000043785.6
 Stap2
signal transducing adaptor family member 2
chr9_+_108508005 0.591 ENSMUST00000006838.8
ENSMUST00000134939.1
 Qars

glutaminyl-tRNA synthetase

chr8_-_69996326 0.572 ENSMUST00000177851.1
ENSMUST00000065169.4
 Gatad2a

GATA zinc finger domain containing 2A

chr2_-_25546872 0.529 ENSMUST00000114234.1
ENSMUST00000028311.6
 Traf2

TNF receptor-associated factor 2

chr10_+_128747850 0.505 ENSMUST00000163377.2
 Wibg
within bgcn homolog (Drosophila)
chr8_+_123477859 0.495 ENSMUST00000001520.7
 Afg3l1
AFG3(ATPase family gene 3)-like 1 (yeast)
chr12_+_90738201 0.447 ENSMUST00000181874.1
 Gm26512
predicted gene, 26512
chr9_-_44268156 0.406 ENSMUST00000169651.1
 Nlrx1
NLR family member X1
chr14_-_57133268 0.404 ENSMUST00000160703.1
 Gjb6
gap junction protein, beta 6
chr7_+_12927410 0.381 ENSMUST00000045870.4
 2310014L17Rik
RIKEN cDNA 2310014L17 gene
chr5_-_86676346 0.375 ENSMUST00000038448.6
 Tmprss11bnl
transmembrane protease, serine 11b N terminal like
chr12_-_54656496 0.302 ENSMUST00000056228.6
 Sptssa
serine palmitoyltransferase, small subunit A
chr17_+_43389436 0.291 ENSMUST00000113599.1
 Gpr116
G protein-coupled receptor 116
chr4_-_19570073 0.254 ENSMUST00000029885.4
 Cpne3
copine III
chr4_-_155086271 0.240 ENSMUST00000030914.3
 Rer1
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)
chr7_-_30552255 0.234 ENSMUST00000108165.1
ENSMUST00000153594.1
 BC053749

cDNA sequence BC053749

chr17_-_34628005 0.185 ENSMUST00000166040.2
 Ppt2
palmitoyl-protein thioesterase 2
chr9_+_15239045 0.127 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr4_+_155086577 0.111 ENSMUST00000030915.4
ENSMUST00000155775.1
ENSMUST00000127457.1
 Morn1


MORN repeat containing 1


chr7_+_65693417 0.106 ENSMUST00000032726.7
ENSMUST00000107495.3
 Tm2d3

TM2 domain containing 3

chr6_-_113377510 0.058 ENSMUST00000099118.2
 Tada3
transcriptional adaptor 3
chr6_-_113377376 0.058 ENSMUST00000043333.2
 Tada3
transcriptional adaptor 3
chr19_+_18631927 0.025 ENSMUST00000159572.1
ENSMUST00000042392.7
 Nmrk1

nicotinamide riboside kinase 1

chr7_-_102065044 0.017 ENSMUST00000130074.1
ENSMUST00000131104.1
ENSMUST00000096639.5
 Rnf121


ring finger protein 121


chr7_+_65693447 0.013 ENSMUST00000143508.1
 Tm2d3
TM2 domain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.6 1.9 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.6 2.9 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.4 3.5 GO:0090527 actin filament reorganization(GO:0090527)
0.2 1.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 0.5 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.6 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.1 1.0 GO:0032782 bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 0.5 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 1.4 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 0.4 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 0.8 GO:0061684 chaperone-mediated autophagy(GO:0061684)
0.1 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 1.9 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.5 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.1 0.8 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 1.1 GO:0001706 endoderm formation(GO:0001706)
0.0 0.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.1 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0031088 platelet dense granule membrane(GO:0031088)
0.2 0.5 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 0.5 GO:0005745 m-AAA complex(GO:0005745)
0.1 1.0 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.6 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 4.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.3 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 3.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.9 GO:0001891 phagocytic cup(GO:0001891) podosome(GO:0002102)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 3.5 GO:0005884 actin filament(GO:0005884)
0.0 0.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.5 GO:0005604 basement membrane(GO:0005604)
0.0 2.9 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.4 3.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.3 0.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758)
0.0 0.5 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.5 GO:0031996 thioesterase binding(GO:0031996)
0.0 3.3 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.2 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.6 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812)