Motif ID: Gsc2_Dmbx1

Z-value: 0.657

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_1159399280.362.3e-03Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_137766474 15.700 ENSMUST00000139951.1
Alpl
alkaline phosphatase, liver/bone/kidney
chr4_+_154960915 8.849 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr14_-_118052235 8.702 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr2_+_91259822 7.487 ENSMUST00000138470.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr5_+_3344194 6.414 ENSMUST00000042410.4
Cdk6
cyclin-dependent kinase 6
chr5_+_3343893 6.252 ENSMUST00000165117.1
Cdk6
cyclin-dependent kinase 6
chr11_-_52282564 5.696 ENSMUST00000086844.3
Tcf7
transcription factor 7, T cell specific
chr11_+_78322965 4.670 ENSMUST00000017534.8
Aldoc
aldolase C, fructose-bisphosphate
chr14_-_31640878 4.581 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
Hacl1


2-hydroxyacyl-CoA lyase 1


chr17_+_35861318 4.278 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr17_-_58991343 3.619 ENSMUST00000025064.7
2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr17_+_35861343 3.484 ENSMUST00000172931.1
Nrm
nurim (nuclear envelope membrane protein)
chr1_+_44551483 3.462 ENSMUST00000074525.3
Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr5_+_77265454 3.210 ENSMUST00000080359.5
Rest
RE1-silencing transcription factor
chr9_+_50617516 3.209 ENSMUST00000141366.1
Pih1d2
PIH1 domain containing 2
chr11_-_68973840 2.993 ENSMUST00000038644.4
Rangrf
RAN guanine nucleotide release factor
chr13_-_116309639 2.950 ENSMUST00000036060.6
Isl1
ISL1 transcription factor, LIM/homeodomain
chr13_+_3361029 2.582 ENSMUST00000179981.1
Gm16505
predicted gene 16505
chr10_-_22149270 2.277 ENSMUST00000179054.1
ENSMUST00000069372.6
E030030I06Rik

RIKEN cDNA E030030I06 gene

chr1_+_44551650 2.242 ENSMUST00000160854.1
Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr7_-_133015248 2.161 ENSMUST00000169570.1
Ctbp2
C-terminal binding protein 2
chr2_-_51972990 1.981 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr11_-_90687572 1.973 ENSMUST00000107869.2
ENSMUST00000154599.1
ENSMUST00000107868.1
ENSMUST00000020849.2
Tom1l1



target of myb1-like 1 (chicken)



chr7_-_105752193 1.928 ENSMUST00000033184.4
Tpp1
tripeptidyl peptidase I
chr2_+_164562579 1.924 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
Wfdc2


WAP four-disulfide core domain 2


chr4_-_141053660 1.875 ENSMUST00000040222.7
Crocc
ciliary rootlet coiled-coil, rootletin
chr2_-_51973219 1.812 ENSMUST00000028314.2
Nmi
N-myc (and STAT) interactor
chrX_-_23285532 1.787 ENSMUST00000115319.2
Klhl13
kelch-like 13
chr1_+_178187417 1.723 ENSMUST00000161075.1
ENSMUST00000027783.7
Desi2

desumoylating isopeptidase 2

chr19_-_12765447 1.680 ENSMUST00000112933.1
Cntf
ciliary neurotrophic factor
chr16_-_35490873 1.680 ENSMUST00000023550.7
Pdia5
protein disulfide isomerase associated 5
chr4_-_133968611 1.628 ENSMUST00000102552.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr2_-_121456693 1.579 ENSMUST00000110613.2
ENSMUST00000056312.3
Serinc4

serine incorporator 4

chrX_+_134585644 1.466 ENSMUST00000113211.1
Rpl36a
ribosomal protein L36A
chr1_+_12692430 1.461 ENSMUST00000180062.1
ENSMUST00000177608.1
Sulf1

sulfatase 1

chr3_-_103737995 1.340 ENSMUST00000029440.8
Olfml3
olfactomedin-like 3
chr2_-_73486456 1.325 ENSMUST00000141264.1
Wipf1
WAS/WASL interacting protein family, member 1
chr2_+_120476911 1.320 ENSMUST00000110716.1
ENSMUST00000028748.6
ENSMUST00000090028.5
ENSMUST00000110719.2
Capn3



calpain 3



chr8_+_78509319 1.315 ENSMUST00000034111.8
Slc10a7
solute carrier family 10 (sodium/bile acid cotransporter family), member 7
chr19_-_47919269 1.234 ENSMUST00000095998.5
Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr13_-_97747373 1.221 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr2_+_102659213 1.201 ENSMUST00000111213.1
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr8_-_113848615 1.126 ENSMUST00000093113.4
Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr1_-_155232710 1.094 ENSMUST00000035914.3
BC034090
cDNA sequence BC034090
chr10_+_80292453 1.070 ENSMUST00000068408.7
ENSMUST00000062674.6
Rps15

ribosomal protein S15

chr5_-_96161990 1.059 ENSMUST00000155901.1
Cnot6l
CCR4-NOT transcription complex, subunit 6-like
chr1_+_178187721 1.028 ENSMUST00000159284.1
Desi2
desumoylating isopeptidase 2
chr9_-_60838200 1.025 ENSMUST00000063858.7
Gm9869
predicted gene 9869
chr11_+_98026695 0.987 ENSMUST00000092425.4
Rpl19
ribosomal protein L19
chr2_-_24049389 0.950 ENSMUST00000051416.5
Hnmt
histamine N-methyltransferase
chr13_+_23752267 0.941 ENSMUST00000091703.2
Hist1h3b
histone cluster 1, H3b
chr13_-_23562369 0.926 ENSMUST00000105107.1
Hist1h3e
histone cluster 1, H3e
chr19_+_43752996 0.888 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
Cutc


cutC copper transporter homolog (E.coli)


chr19_+_36083696 0.790 ENSMUST00000025714.7
Rpp30
ribonuclease P/MRP 30 subunit
chr1_-_168431695 0.749 ENSMUST00000176790.1
Pbx1
pre B cell leukemia homeobox 1
chr13_-_21783391 0.747 ENSMUST00000099704.3
Hist1h3i
histone cluster 1, H3i
chr11_+_23256566 0.716 ENSMUST00000136235.1
Xpo1
exportin 1, CRM1 homolog (yeast)
chr7_-_15879844 0.699 ENSMUST00000172758.1
ENSMUST00000044434.6
Crx

cone-rod homeobox containing gene

chr2_+_121456963 0.680 ENSMUST00000126764.1
Hypk
huntingtin interacting protein K
chr4_-_141053704 0.676 ENSMUST00000102491.3
Crocc
ciliary rootlet coiled-coil, rootletin
chr19_+_46056539 0.656 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr13_-_113618549 0.648 ENSMUST00000109241.3
Snx18
sorting nexin 18
chr13_+_75089826 0.561 ENSMUST00000022075.4
Pcsk1
proprotein convertase subtilisin/kexin type 1
chr2_+_102658640 0.407 ENSMUST00000080210.3
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr5_+_149184678 0.387 ENSMUST00000139474.1
ENSMUST00000117878.1
Uspl1

ubiquitin specific peptidase like 1

chr4_-_139833524 0.359 ENSMUST00000030508.7
Pax7
paired box gene 7
chr1_-_44218952 0.344 ENSMUST00000054801.3
Mettl21e
methyltransferase like 21E
chr7_-_127725616 0.338 ENSMUST00000076091.2
Ctf2
cardiotrophin 2
chr16_-_76403673 0.311 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chrM_+_8600 0.296 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr2_-_30093642 0.277 ENSMUST00000102865.4
Zdhhc12
zinc finger, DHHC domain containing 12
chr7_+_101969796 0.252 ENSMUST00000084852.5
Numa1
nuclear mitotic apparatus protein 1
chr16_-_4213404 0.251 ENSMUST00000023165.6
Crebbp
CREB binding protein
chr4_+_102589687 0.238 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr1_-_168431502 0.219 ENSMUST00000064438.4
Pbx1
pre B cell leukemia homeobox 1
chr14_-_54617993 0.215 ENSMUST00000022803.4
Psmb5
proteasome (prosome, macropain) subunit, beta type 5
chr2_-_9883993 0.214 ENSMUST00000114915.2
9230102O04Rik
RIKEN cDNA 9230102O04 gene
chr13_-_97747399 0.209 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr5_-_134456702 0.203 ENSMUST00000073161.5
ENSMUST00000171794.2
ENSMUST00000111245.2
ENSMUST00000100654.3
ENSMUST00000167084.2
ENSMUST00000100652.3
ENSMUST00000100650.3
ENSMUST00000074114.5
Gtf2ird1







general transcription factor II I repeat domain-containing 1







chr11_-_5099036 0.199 ENSMUST00000102930.3
Ewsr1
Ewing sarcoma breakpoint region 1
chr18_-_12305638 0.198 ENSMUST00000122408.1
ENSMUST00000118525.1
ENSMUST00000142066.1
Ankrd29


ankyrin repeat domain 29


chr11_-_5099053 0.181 ENSMUST00000093365.5
ENSMUST00000073308.4
Ewsr1

Ewing sarcoma breakpoint region 1

chr2_-_30093607 0.176 ENSMUST00000081838.6
Zdhhc12
zinc finger, DHHC domain containing 12
chr3_-_8964037 0.162 ENSMUST00000091354.5
ENSMUST00000094381.4
Tpd52

tumor protein D52

chr19_-_53371766 0.160 ENSMUST00000086887.1
Gm10197
predicted gene 10197
chr17_-_35164891 0.109 ENSMUST00000025253.5
Prrc2a
proline-rich coiled-coil 2A
chr8_-_60954726 0.109 ENSMUST00000110302.1
Clcn3
chloride channel 3
chr10_+_128225830 0.058 ENSMUST00000026455.7
Mip
major intrinsic protein of eye lens fiber
chr14_-_105177280 0.049 ENSMUST00000100327.3
ENSMUST00000022715.7
Rbm26

RNA binding motif protein 26


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.7 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
2.2 8.8 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
1.5 8.7 GO:0006570 tyrosine metabolic process(GO:0006570)
1.3 3.8 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
1.0 2.9 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.9 4.6 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.9 2.6 GO:0032053 ciliary basal body organization(GO:0032053)
0.8 3.2 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.7 5.7 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.5 15.7 GO:0046677 response to antibiotic(GO:0046677)
0.5 4.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.4 1.3 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.4 1.7 GO:0046533 negative regulation of photoreceptor cell differentiation(GO:0046533)
0.4 1.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 7.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.3 1.6 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3 1.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 3.0 GO:2000010 positive regulation of protein localization to cell surface(GO:2000010)
0.2 2.0 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 0.6 GO:0036089 cleavage furrow formation(GO:0036089)
0.1 5.8 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.1 1.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 0.4 GO:0030576 Cajal body organization(GO:0030576)
0.1 1.1 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.1 2.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 1.9 GO:0043171 peptide catabolic process(GO:0043171)
0.1 2.0 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 1.3 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.1 1.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.1 0.3 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.9 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 0.4 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.2 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 1.2 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.0 0.8 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 1.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.5 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.7 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.3 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0 1.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 1.8 GO:0000910 cytokinesis(GO:0000910)
0.0 0.9 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 15.7 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.6 1.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.5 7.8 GO:0005652 nuclear lamina(GO:0005652)
0.3 8.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 12.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 2.6 GO:0035253 ciliary rootlet(GO:0035253)
0.1 5.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 2.0 GO:0097470 ribbon synapse(GO:0097470)
0.1 0.8 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.1 2.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.6 GO:0005642 annulate lamellae(GO:0005642)
0.1 1.1 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 1.6 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0000235 astral microtubule(GO:0000235)
0.0 3.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.3 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0005839 proteasome core complex(GO:0005839)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 15.7 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.8 4.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.6 8.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.5 4.6 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.5 7.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.5 1.9 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.4 1.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 12.7 GO:0030332 cyclin binding(GO:0030332)
0.3 1.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 2.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.3 3.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.2 1.3 GO:0031432 titin binding(GO:0031432)
0.2 1.0 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 3.2 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 0.4 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.1 1.6 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 3.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 1.7 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 2.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.8 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 14.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 1.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 2.0 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 2.6 GO:0019894 kinesin binding(GO:0019894)
0.0 1.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 2.0 GO:0030276 clathrin binding(GO:0030276)
0.0 0.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.9 GO:0005507 copper ion binding(GO:0005507)
0.0 0.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)