Motif ID: Gsc2_Dmbx1

Z-value: 0.657

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_1159399280.362.3e-03Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 89 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_137766474 15.700 ENSMUST00000139951.1
Alpl
alkaline phosphatase, liver/bone/kidney
chr4_+_154960915 8.849 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr14_-_118052235 8.702 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr2_+_91259822 7.487 ENSMUST00000138470.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr5_+_3344194 6.414 ENSMUST00000042410.4
Cdk6
cyclin-dependent kinase 6
chr5_+_3343893 6.252 ENSMUST00000165117.1
Cdk6
cyclin-dependent kinase 6
chr11_-_52282564 5.696 ENSMUST00000086844.3
Tcf7
transcription factor 7, T cell specific
chr11_+_78322965 4.670 ENSMUST00000017534.8
Aldoc
aldolase C, fructose-bisphosphate
chr14_-_31640878 4.581 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
Hacl1


2-hydroxyacyl-CoA lyase 1


chr17_+_35861318 4.278 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr17_-_58991343 3.619 ENSMUST00000025064.7
2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr17_+_35861343 3.484 ENSMUST00000172931.1
Nrm
nurim (nuclear envelope membrane protein)
chr1_+_44551483 3.462 ENSMUST00000074525.3
Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr5_+_77265454 3.210 ENSMUST00000080359.5
Rest
RE1-silencing transcription factor
chr9_+_50617516 3.209 ENSMUST00000141366.1
Pih1d2
PIH1 domain containing 2
chr11_-_68973840 2.993 ENSMUST00000038644.4
Rangrf
RAN guanine nucleotide release factor
chr13_-_116309639 2.950 ENSMUST00000036060.6
Isl1
ISL1 transcription factor, LIM/homeodomain
chr13_+_3361029 2.582 ENSMUST00000179981.1
Gm16505
predicted gene 16505
chr10_-_22149270 2.277 ENSMUST00000179054.1
ENSMUST00000069372.6
E030030I06Rik

RIKEN cDNA E030030I06 gene

chr1_+_44551650 2.242 ENSMUST00000160854.1
Gulp1
GULP, engulfment adaptor PTB domain containing 1

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 15.7 GO:0046677 response to antibiotic(GO:0046677)
4.2 12.7 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
2.2 8.8 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
1.5 8.7 GO:0006570 tyrosine metabolic process(GO:0006570)
0.3 7.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 5.8 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.7 5.7 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.5 4.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.9 4.6 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
1.3 3.8 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.8 3.2 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.2 3.0 GO:2000010 positive regulation of protein localization to cell surface(GO:2000010)
1.0 2.9 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.9 2.6 GO:0032053 ciliary basal body organization(GO:0032053)
0.1 2.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 2.0 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 2.0 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 1.9 GO:0043171 peptide catabolic process(GO:0043171)
0.0 1.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 1.8 GO:0000910 cytokinesis(GO:0000910)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 15.7 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.3 12.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 8.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.5 7.8 GO:0005652 nuclear lamina(GO:0005652)
0.1 5.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 3.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 2.6 GO:0035253 ciliary rootlet(GO:0035253)
0.1 2.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 2.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 2.0 GO:0097470 ribbon synapse(GO:0097470)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.6 1.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 1.6 GO:0030673 axolemma(GO:0030673)
0.0 1.3 GO:0030315 T-tubule(GO:0030315)
0.1 1.1 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.8 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.1 0.6 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.3 GO:0000235 astral microtubule(GO:0000235)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 15.7 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 14.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.3 12.7 GO:0030332 cyclin binding(GO:0030332)
0.6 8.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.5 7.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.8 4.7 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.5 4.6 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 3.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.3 3.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 3.2 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 2.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 2.6 GO:0019894 kinesin binding(GO:0019894)
0.3 2.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 2.0 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 2.0 GO:0030276 clathrin binding(GO:0030276)
0.5 1.9 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 1.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 1.7 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.4 1.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.6 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)