Motif ID: Gsx1_Alx1_Mixl1_Lbx2

Z-value: 0.487

Transcription factors associated with Gsx1_Alx1_Mixl1_Lbx2:

Gene SymbolEntrez IDGene Name
Alx1 ENSMUSG00000036602.7 Alx1
Gsx1 ENSMUSG00000053129.5 Gsx1
Lbx2 ENSMUSG00000034968.2 Lbx2
Mixl1 ENSMUSG00000026497.7 Mixl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx1mm10_v2_chr10_-_103028771_103028782-0.491.5e-05Click!
Gsx1mm10_v2_chr5_+_147188678_147188696-0.397.3e-04Click!


Activity profile for motif Gsx1_Alx1_Mixl1_Lbx2.

activity profile for motif Gsx1_Alx1_Mixl1_Lbx2


Sorted Z-values histogram for motif Gsx1_Alx1_Mixl1_Lbx2

Sorted Z-values for motif Gsx1_Alx1_Mixl1_Lbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx1_Alx1_Mixl1_Lbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_84417359 6.310 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr5_-_62766153 5.653 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_143933204 4.526 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr13_+_23574381 4.489 ENSMUST00000090776.4
 Hist1h2ad
histone cluster 1, H2ad
chr2_+_116067213 4.413 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr2_-_116067391 3.724 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr7_+_126950687 3.443 ENSMUST00000106333.1
 Sez6l2
seizure related 6 homolog like 2
chr7_+_126950518 3.383 ENSMUST00000106335.1
ENSMUST00000146017.1
 Sez6l2

seizure related 6 homolog like 2

chr4_-_155056784 3.048 ENSMUST00000131173.2
 Plch2
phospholipase C, eta 2
chr9_-_55919605 3.046 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chrX_-_143933089 2.980 ENSMUST00000087313.3
 Dcx
doublecortin
chr7_+_103550368 2.721 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr9_+_118478182 2.461 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr18_+_57468478 2.449 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr16_-_97170707 2.340 ENSMUST00000056102.7
 Dscam
Down syndrome cell adhesion molecule
chr7_+_29071597 2.289 ENSMUST00000180926.1
 Gm26604
predicted gene, 26604
chr13_+_44121167 2.287 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr5_+_17574726 2.255 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr16_-_45724600 2.192 ENSMUST00000096057.4
 Tagln3
transgelin 3
chr9_+_118478344 2.107 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 7.9 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.4 7.5 GO:0021860 pyramidal neuron development(GO:0021860)
0.3 7.3 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.2 6.0 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.8 5.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 4.7 GO:0006342 chromatin silencing(GO:0006342)
1.5 4.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.0 3.4 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.9 2.8 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 2.8 GO:0007608 sensory perception of smell(GO:0007608)
0.0 2.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.8 2.3 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.7 2.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 1.9 GO:0007379 segment specification(GO:0007379)
0.6 1.8 GO:1902605 heterotrimeric G-protein complex assembly(GO:1902605)
0.6 1.8 GO:0050975 sensory perception of touch(GO:0050975)
0.2 1.7 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 1.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.7 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.1 1.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0005874 microtubule(GO:0005874)
0.1 6.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 4.7 GO:0070469 respiratory chain(GO:0070469)
0.0 4.3 GO:0000790 nuclear chromatin(GO:0000790)
0.0 3.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.9 2.8 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 2.3 GO:0030426 growth cone(GO:0030426)
0.1 2.2 GO:0030673 axolemma(GO:0030673)
0.1 2.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.0 GO:0043209 myelin sheath(GO:0043209)
0.1 1.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.5 GO:0031045 dense core granule(GO:0031045)
0.5 1.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.4 1.4 GO:0060187 cell pole(GO:0060187)
0.1 1.4 GO:0000124 SAGA complex(GO:0000124)
0.1 1.3 GO:0031527 filopodium membrane(GO:0031527)
0.0 1.3 GO:0072562 blood microparticle(GO:0072562)
0.1 0.9 GO:0090543 Flemming body(GO:0090543)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 7.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.3 7.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.6 6.2 GO:0038191 neuropilin binding(GO:0038191)
0.1 5.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 4.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 4.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 3.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 3.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.4 2.8 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.3 2.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.9 GO:0043422 protein kinase B binding(GO:0043422)
0.1 1.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 1.8 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.4 1.7 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.1 1.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.4 GO:0070412 R-SMAD binding(GO:0070412)
0.2 1.3 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.2 1.3 GO:0050693 LBD domain binding(GO:0050693)
0.0 1.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)