Motif ID: Gsx2_Hoxd3_Vax1
Z-value: 0.725
Transcription factors associated with Gsx2_Hoxd3_Vax1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Gsx2 | ENSMUSG00000035946.6 | Gsx2 |
Hoxd3 | ENSMUSG00000079277.3 | Hoxd3 |
Vax1 | ENSMUSG00000006270.6 | Vax1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Gsx2 | mm10_v2_chr5_+_75075464_75075601 | 0.78 | 2.0e-15 | Click! |
Vax1 | mm10_v2_chr19_-_59170978_59170978 | 0.75 | 8.2e-14 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
7.9 | 31.4 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
2.9 | 8.7 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
2.4 | 7.2 | GO:0097212 | lysosomal membrane organization(GO:0097212) |
2.3 | 9.1 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
2.2 | 6.6 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
1.8 | 5.5 | GO:1904395 | regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
1.7 | 5.0 | GO:0008228 | opsonization(GO:0008228) modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
1.5 | 4.6 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
1.2 | 3.5 | GO:0006059 | hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401) |
1.2 | 8.1 | GO:0019532 | oxalate transport(GO:0019532) |
1.1 | 5.7 | GO:0014719 | skeletal muscle satellite cell activation(GO:0014719) |
1.0 | 3.0 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
0.7 | 12.7 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
0.6 | 2.5 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
0.6 | 4.8 | GO:0048625 | myoblast fate commitment(GO:0048625) |
0.5 | 2.4 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
0.4 | 3.8 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
0.4 | 2.0 | GO:0015819 | lysine transport(GO:0015819) |
0.4 | 4.9 | GO:0031017 | exocrine pancreas development(GO:0031017) |
0.3 | 1.0 | GO:0015960 | diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966) |
0.3 | 1.9 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
0.3 | 0.8 | GO:0050929 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
0.3 | 0.8 | GO:0045819 | positive regulation of glycogen catabolic process(GO:0045819) |
0.2 | 6.7 | GO:0007638 | mechanosensory behavior(GO:0007638) |
0.2 | 0.6 | GO:0009193 | pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048) |
0.2 | 0.8 | GO:0035553 | oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553) |
0.2 | 0.6 | GO:0010757 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) negative regulation of plasminogen activation(GO:0010757) regulation of vascular wound healing(GO:0061043) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
0.2 | 3.2 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.2 | 1.3 | GO:0060923 | cardiac muscle cell fate commitment(GO:0060923) |
0.2 | 1.9 | GO:0048199 | vesicle targeting, to, from or within Golgi(GO:0048199) |
0.2 | 0.6 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
0.1 | 8.7 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
0.1 | 0.9 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
0.1 | 0.6 | GO:0030091 | protein repair(GO:0030091) |
0.1 | 2.7 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
0.1 | 2.9 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
0.1 | 0.5 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
0.1 | 4.9 | GO:0051693 | actin filament capping(GO:0051693) |
0.1 | 2.0 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
0.1 | 1.5 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
0.1 | 1.1 | GO:0060134 | prepulse inhibition(GO:0060134) |
0.1 | 1.1 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
0.1 | 0.6 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
0.1 | 0.5 | GO:0051461 | protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
0.1 | 1.5 | GO:0006907 | pinocytosis(GO:0006907) |
0.1 | 2.7 | GO:0030901 | midbrain development(GO:0030901) |
0.1 | 4.5 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
0.1 | 4.3 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
0.0 | 0.9 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
0.0 | 0.2 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
0.0 | 0.7 | GO:0043968 | histone H2A acetylation(GO:0043968) |
0.0 | 0.4 | GO:1990173 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173) |
0.0 | 0.4 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
0.0 | 0.5 | GO:0006670 | sphingosine metabolic process(GO:0006670) |
0.0 | 1.1 | GO:0031365 | N-terminal protein amino acid modification(GO:0031365) |
0.0 | 0.4 | GO:0003215 | cardiac right ventricle morphogenesis(GO:0003215) |
0.0 | 0.7 | GO:0019731 | antibacterial humoral response(GO:0019731) |
0.0 | 0.5 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
0.0 | 2.4 | GO:0007601 | visual perception(GO:0007601) |
0.0 | 0.7 | GO:0006221 | pyrimidine nucleotide biosynthetic process(GO:0006221) |
0.0 | 0.5 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
0.0 | 0.3 | GO:0034453 | microtubule anchoring(GO:0034453) |
0.0 | 0.3 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
0.0 | 1.4 | GO:0000725 | double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725) |
0.0 | 0.6 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
0.0 | 1.8 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
0.0 | 0.1 | GO:0097186 | amelogenesis(GO:0097186) |
0.0 | 0.5 | GO:0043029 | T cell homeostasis(GO:0043029) |
0.0 | 1.4 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
0.0 | 0.5 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.8 | 31.4 | GO:0043205 | fibril(GO:0043205) |
0.9 | 3.5 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
0.5 | 4.8 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
0.4 | 5.5 | GO:0016600 | flotillin complex(GO:0016600) |
0.4 | 1.8 | GO:0008623 | CHRAC(GO:0008623) |
0.1 | 4.9 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.1 | 3.6 | GO:0001891 | phagocytic cup(GO:0001891) |
0.1 | 8.7 | GO:0016459 | myosin complex(GO:0016459) |
0.1 | 1.9 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
0.1 | 0.5 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
0.1 | 0.6 | GO:0042583 | chromaffin granule(GO:0042583) |
0.1 | 1.0 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
0.1 | 7.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.1 | 1.9 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
0.1 | 12.7 | GO:0000792 | heterochromatin(GO:0000792) |
0.1 | 0.6 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
0.1 | 0.6 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
0.1 | 0.3 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.1 | 0.7 | GO:0034709 | methylosome(GO:0034709) |
0.0 | 1.0 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
0.0 | 1.1 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
0.0 | 1.5 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.0 | 8.9 | GO:0030426 | growth cone(GO:0030426) |
0.0 | 0.4 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
0.0 | 9.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.0 | 0.5 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.0 | 5.5 | GO:0008021 | synaptic vesicle(GO:0008021) |
0.0 | 0.6 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
0.0 | 0.5 | GO:0045120 | pronucleus(GO:0045120) |
0.0 | 0.7 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
0.0 | 0.5 | GO:0070382 | exocytic vesicle(GO:0070382) |
0.0 | 2.6 | GO:0005923 | bicellular tight junction(GO:0005923) |
0.0 | 0.2 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
0.0 | 1.1 | GO:0098878 | ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878) |
0.0 | 1.4 | GO:0030496 | midbody(GO:0030496) |
0.0 | 0.8 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
0.0 | 0.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.0 | 1.4 | GO:0030018 | Z disc(GO:0030018) |
0.0 | 0.6 | GO:0045335 | phagocytic vesicle(GO:0045335) |
0.0 | 3.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
0.0 | 3.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
0.0 | 0.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 2.4 | GO:0043235 | receptor complex(GO:0043235) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
6.3 | 31.4 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
1.0 | 5.0 | GO:0001849 | complement component C1q binding(GO:0001849) |
0.8 | 2.4 | GO:0005118 | sevenless binding(GO:0005118) |
0.7 | 8.1 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
0.7 | 8.7 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.5 | 4.9 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
0.5 | 3.8 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
0.3 | 2.0 | GO:0015189 | L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189) |
0.3 | 0.8 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
0.3 | 2.1 | GO:0031432 | titin binding(GO:0031432) |
0.3 | 4.6 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.2 | 1.7 | GO:0045125 | bioactive lipid receptor activity(GO:0045125) |
0.2 | 1.5 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
0.2 | 1.7 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.2 | 5.5 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.2 | 0.8 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
0.2 | 4.8 | GO:0045295 | gamma-catenin binding(GO:0045295) |
0.2 | 2.7 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
0.2 | 4.5 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
0.2 | 1.1 | GO:0070191 | methionine-R-sulfoxide reductase activity(GO:0070191) |
0.1 | 8.7 | GO:0030507 | spectrin binding(GO:0030507) |
0.1 | 3.2 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.1 | 2.4 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
0.1 | 3.5 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
0.1 | 2.0 | GO:0016594 | glycine binding(GO:0016594) |
0.1 | 0.9 | GO:0005451 | monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) |
0.1 | 0.8 | GO:0043237 | laminin-1 binding(GO:0043237) |
0.1 | 0.7 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
0.1 | 0.5 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
0.1 | 0.6 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
0.1 | 1.9 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.1 | 0.6 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
0.1 | 3.3 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
0.1 | 2.9 | GO:0005109 | frizzled binding(GO:0005109) |
0.1 | 3.0 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
0.1 | 3.1 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.1 | 0.6 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
0.1 | 0.9 | GO:0034951 | pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011) |
0.1 | 20.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
0.1 | 1.1 | GO:0005234 | extracellular-glutamate-gated ion channel activity(GO:0005234) |
0.1 | 0.6 | GO:0030228 | lipoprotein particle receptor activity(GO:0030228) |
0.1 | 0.3 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
0.0 | 0.2 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
0.0 | 0.5 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
0.0 | 6.6 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
0.0 | 0.3 | GO:0019865 | immunoglobulin binding(GO:0019865) |
0.0 | 0.7 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
0.0 | 0.6 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
0.0 | 5.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
0.0 | 0.7 | GO:0008327 | methyl-CpG binding(GO:0008327) |
0.0 | 0.5 | GO:0016805 | dipeptidase activity(GO:0016805) |
0.0 | 1.5 | GO:0004812 | aminoacyl-tRNA ligase activity(GO:0004812) |
0.0 | 0.5 | GO:0042556 | cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
0.0 | 0.1 | GO:0022821 | calcium, potassium:sodium antiporter activity(GO:0008273) potassium ion antiporter activity(GO:0022821) |
0.0 | 1.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.0 | 0.5 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
0.0 | 0.5 | GO:0017161 | JUN kinase phosphatase activity(GO:0008579) phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003) |
0.0 | 11.3 | GO:0044212 | transcription regulatory region DNA binding(GO:0044212) |
0.0 | 0.8 | GO:0004601 | peroxidase activity(GO:0004601) |
0.0 | 0.2 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 0.3 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |