Motif ID: Hcfc1_Six5_Smarcc2_Zfp143

Z-value: 2.650

Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143:

Gene SymbolEntrez IDGene Name
Hcfc1 ENSMUSG00000031386.8 Hcfc1
Six5 ENSMUSG00000040841.5 Six5
Smarcc2 ENSMUSG00000025369.8 Smarcc2
Zfp143 ENSMUSG00000061079.7 Zfp143

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smarcc2mm10_v2_chr10_+_128459236_1284592480.467.0e-05Click!
Six5mm10_v2_chr7_+_19094594_19094633-0.291.3e-02Click!
Zfp143mm10_v2_chr7_+_110061702_1100617320.171.7e-01Click!
Hcfc1mm10_v2_chrX_-_73966329_739663760.085.0e-01Click!


Activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143.

activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143


Sorted Z-values histogram for motif Hcfc1_Six5_Smarcc2_Zfp143

Sorted Z-values for motif Hcfc1_Six5_Smarcc2_Zfp143



Network of associatons between targets according to the STRING database.



First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_44384803 11.165 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr13_-_110280103 10.546 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr7_+_44384604 10.296 ENSMUST00000130707.1
ENSMUST00000130844.1
 Syt3

synaptotagmin III

chr9_+_83548309 9.443 ENSMUST00000113215.3
 Sh3bgrl2
SH3 domain binding glutamic acid-rich protein like 2
chr15_-_43869993 8.789 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr7_+_6172482 8.413 ENSMUST00000108567.1
ENSMUST00000054680.5
ENSMUST00000108566.1
 Zfp444


zinc finger protein 444


chr7_+_100706702 8.196 ENSMUST00000049053.7
 Fam168a
family with sequence similarity 168, member A
chr2_-_148732457 8.070 ENSMUST00000028926.6
 Napb
N-ethylmaleimide sensitive fusion protein attachment protein beta
chr8_-_106337987 7.875 ENSMUST00000067512.7
 Smpd3
sphingomyelin phosphodiesterase 3, neutral
chr7_+_44384098 7.508 ENSMUST00000118962.1
ENSMUST00000118831.1
 Syt3

synaptotagmin III

chr4_+_83417715 7.493 ENSMUST00000030206.3
ENSMUST00000071544.4
 Snapc3

small nuclear RNA activating complex, polypeptide 3

chr7_+_19119853 7.290 ENSMUST00000053109.3
 Fbxo46
F-box protein 46
chr5_-_135934590 7.243 ENSMUST00000055808.5
 Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr7_+_130865835 6.679 ENSMUST00000075181.4
ENSMUST00000048180.5
 Plekha1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

chr1_+_176814660 6.308 ENSMUST00000056773.8
ENSMUST00000027785.8
 Sdccag8

serologically defined colon cancer antigen 8

chr2_+_71211941 6.244 ENSMUST00000112144.2
ENSMUST00000100028.3
ENSMUST00000112136.1
 Dync1i2


dynein cytoplasmic 1 intermediate chain 2


chr7_+_29768552 6.185 ENSMUST00000032802.4
 Zfp84
zinc finger protein 84
chr1_+_172482199 6.124 ENSMUST00000135267.1
ENSMUST00000052629.6
ENSMUST00000111235.2
 Igsf9


immunoglobulin superfamily, member 9


chr1_+_151428612 6.119 ENSMUST00000065625.5
 Trmt1l
tRNA methyltransferase 1 like
chr2_+_71211706 6.099 ENSMUST00000112142.1
ENSMUST00000112139.1
ENSMUST00000112140.1
ENSMUST00000112138.1
 Dync1i2



dynein cytoplasmic 1 intermediate chain 2




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 373 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 85.7 GO:0006355 regulation of transcription, DNA-templated(GO:0006355)
1.6 29.0 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 16.5 GO:0016579 protein deubiquitination(GO:0016579)
0.1 14.7 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
1.2 12.8 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.1 12.2 GO:0098792 xenophagy(GO:0098792)
0.2 12.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.7 11.5 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 10.9 GO:0006412 translation(GO:0006412)
0.1 10.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 10.6 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
1.4 9.7 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
0.5 9.6 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.8 9.5 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.1 9.5 GO:0007018 microtubule-based movement(GO:0007018)
0.1 9.4 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.1 9.3 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 8.9 GO:0008344 adult locomotory behavior(GO:0008344)
0.7 8.0 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
1.3 7.9 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 204 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 69.2 GO:0005634 nucleus(GO:0005634)
0.2 44.8 GO:0070382 exocytic vesicle(GO:0070382)
0.7 19.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.6 16.0 GO:0060077 inhibitory synapse(GO:0060077)
0.1 14.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 11.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 11.1 GO:0005840 ribosome(GO:0005840)
0.1 10.8 GO:0032587 ruffle membrane(GO:0032587)
0.4 10.2 GO:0071565 nBAF complex(GO:0071565)
0.0 10.1 GO:0043025 neuronal cell body(GO:0043025)
0.2 9.4 GO:0031672 A band(GO:0031672)
0.2 8.4 GO:0016592 mediator complex(GO:0016592)
0.2 8.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
1.6 8.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.9 8.0 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.3 8.0 GO:0034451 centriolar satellite(GO:0034451)
0.1 7.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.7 7.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.3 7.3 GO:0070822 Sin3-type complex(GO:0070822)
0.1 6.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 257 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 95.7 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
1.0 29.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 28.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 21.7 GO:0003774 motor activity(GO:0003774)
0.0 20.3 GO:0003723 RNA binding(GO:0003723)
0.4 19.5 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 15.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 13.3 GO:0019208 phosphatase regulator activity(GO:0019208)
0.6 13.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 12.6 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
1.5 12.0 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 11.4 GO:0003676 nucleic acid binding(GO:0003676)
0.1 10.9 GO:0017124 SH3 domain binding(GO:0017124)
0.5 10.5 GO:0031489 myosin V binding(GO:0031489)
0.4 9.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.5 9.5 GO:0008242 omega peptidase activity(GO:0008242)
0.2 8.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
2.0 8.1 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.3 8.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.3 8.0 GO:0071889 14-3-3 protein binding(GO:0071889)