Motif ID: Hdx

Z-value: 5.267


Transcription factors associated with Hdx:

Gene SymbolEntrez IDGene Name
Hdx ENSMUSG00000034551.6 Hdx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hdxmm10_v2_chrX_-_111697069_111697127-0.104.0e-01Click!


Activity profile for motif Hdx.

activity profile for motif Hdx


Sorted Z-values histogram for motif Hdx

Sorted Z-values for motif Hdx



Network of associatons between targets according to the STRING database.



First level regulatory network of Hdx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_3017408 338.651 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 285.634 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3023547 281.721 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3005125 249.708 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3000922 240.145 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3027439 232.898 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3034599 231.900 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3025417 202.926 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr14_-_19418930 191.263 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3018753 165.273 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3004457 152.777 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3036877 148.110 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3037111 138.173 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3013140 132.236 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr2_-_98667264 100.735 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr6_-_23248264 52.783 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_-_154330543 21.060 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr16_-_26989974 14.989 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr13_+_24327415 14.238 ENSMUST00000167746.1
 Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr6_+_30568367 13.426 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chrX_-_143827391 11.044 ENSMUST00000087316.5
 Capn6
calpain 6
chr7_+_46847128 9.028 ENSMUST00000005051.4
 Ldha
lactate dehydrogenase A
chr4_-_43031429 8.217 ENSMUST00000136326.1
 Stoml2
stomatin (Epb7.2)-like 2
chr2_+_105682463 7.873 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr4_+_89137122 7.171 ENSMUST00000058030.7
 Mtap
methylthioadenosine phosphorylase
chr4_-_43031370 6.570 ENSMUST00000138030.1
 Stoml2
stomatin (Epb7.2)-like 2
chr4_-_133753611 6.506 ENSMUST00000145664.2
ENSMUST00000105897.3
 Arid1a

AT rich interactive domain 1A (SWI-like)

chr14_+_62292475 5.940 ENSMUST00000166879.1
 Rnaseh2b
ribonuclease H2, subunit B
chr4_-_97584605 5.853 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 5.519 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_+_174415804 4.703 ENSMUST00000109075.1
ENSMUST00000016397.6
 Nelfcd

negative elongation factor complex member C/D, Th1l

chr17_+_17402672 4.607 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr3_+_95929325 4.568 ENSMUST00000171368.1
ENSMUST00000168106.1
 Anp32e

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr14_+_70774304 4.555 ENSMUST00000022698.7
 Dok2
docking protein 2
chr15_+_10177623 4.536 ENSMUST00000124470.1
 Prlr
prolactin receptor
chr5_-_27501362 4.492 ENSMUST00000155721.1
ENSMUST00000053257.3
 Speer4b

spermatogenesis associated glutamate (E)-rich protein 4b

chr7_+_13398115 4.469 ENSMUST00000005791.7
 Cabp5
calcium binding protein 5
chr7_-_89980935 4.090 ENSMUST00000107234.1
 Eed
embryonic ectoderm development
chr14_+_73138755 3.941 ENSMUST00000171070.1
 Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr9_+_45055166 3.791 ENSMUST00000114664.1
ENSMUST00000093856.3
 Mpzl3

myelin protein zero-like 3

chr14_+_24490678 3.729 ENSMUST00000169826.1
ENSMUST00000112384.3
 Rps24

ribosomal protein S24

chrX_+_56779699 3.708 ENSMUST00000114772.2
ENSMUST00000114768.3
ENSMUST00000155882.1
 Fhl1


four and a half LIM domains 1


chr16_+_37539883 3.541 ENSMUST00000023524.6
 Rabl3
RAB, member of RAS oncogene family-like 3
chr13_+_43370710 2.842 ENSMUST00000066804.4
 Sirt5
sirtuin 5
chr4_-_129640959 2.577 ENSMUST00000132217.1
ENSMUST00000130017.1
ENSMUST00000154105.1
 Txlna


taxilin alpha


chr12_-_23780265 2.549 ENSMUST00000072014.4
 Gm10330
predicted gene 10330
chr2_-_165368723 2.549 ENSMUST00000141140.1
ENSMUST00000103085.1
 Zfp663

zinc finger protein 663

chrX_+_56779437 2.521 ENSMUST00000114773.3
 Fhl1
four and a half LIM domains 1
chr13_-_63431683 2.383 ENSMUST00000160931.1
ENSMUST00000099444.3
ENSMUST00000161977.1
ENSMUST00000163091.1
 Fancc



Fanconi anemia, complementation group C



chr16_+_14705832 2.365 ENSMUST00000023356.6
 Snai2
snail homolog 2 (Drosophila)
chr2_-_126618655 2.282 ENSMUST00000028838.4
 Hdc
histidine decarboxylase
chr11_+_117232254 2.236 ENSMUST00000106354.2
 Sept9
septin 9
chr11_-_45955465 2.204 ENSMUST00000011398.6
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr4_-_129640691 2.182 ENSMUST00000084264.5
 Txlna
taxilin alpha
chrX_+_143518671 2.087 ENSMUST00000134402.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chrX_-_145505175 1.944 ENSMUST00000143610.1
 Amot
angiomotin
chrX_+_164419782 1.943 ENSMUST00000033754.7
 Piga
phosphatidylinositol glycan anchor biosynthesis, class A
chr10_+_7667503 1.881 ENSMUST00000040135.8
 Nup43
nucleoporin 43
chr12_-_27160311 1.859 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
 Gm9866


predicted gene 9866


chr1_-_84935089 1.776 ENSMUST00000027422.5
 Slc16a14
solute carrier family 16 (monocarboxylic acid transporters), member 14
chr10_-_80918212 1.741 ENSMUST00000057623.7
ENSMUST00000179022.1
 Lmnb2

lamin B2

chr4_+_3938904 1.700 ENSMUST00000120732.1
ENSMUST00000041122.4
ENSMUST00000121651.1
ENSMUST00000121210.1
ENSMUST00000119307.1
ENSMUST00000123769.1
 Chchd7





coiled-coil-helix-coiled-coil-helix domain containing 7





chr8_-_85025268 1.658 ENSMUST00000064314.8
 Asna1
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr1_+_87327044 1.630 ENSMUST00000173173.1
 Gigyf2
GRB10 interacting GYF protein 2
chr19_+_8953826 1.338 ENSMUST00000096239.5
 Tut1
terminal uridylyl transferase 1, U6 snRNA-specific
chr18_-_47333311 1.290 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr5_+_30013141 1.271 ENSMUST00000026845.7
 Il6
interleukin 6
chr14_-_72602945 1.202 ENSMUST00000162825.1
 Fndc3a
fibronectin type III domain containing 3A
chr7_-_128596278 1.199 ENSMUST00000179317.1
 Gm7258
predicted gene 7258
chr15_-_80083374 1.096 ENSMUST00000081650.7
 Rpl3
ribosomal protein L3
chr2_-_130629994 1.073 ENSMUST00000028761.4
ENSMUST00000110262.1
 Ubox5
Fastkd5
U box domain containing 5
FAST kinase domains 5
chr4_+_124880899 1.030 ENSMUST00000059343.6
 Epha10
Eph receptor A10
chr6_+_34709610 1.018 ENSMUST00000031775.6
 Cald1
caldesmon 1
chr6_+_54267131 0.985 ENSMUST00000114402.2
 Chn2
chimerin (chimaerin) 2
chr11_+_98446826 0.941 ENSMUST00000019456.4
 Grb7
growth factor receptor bound protein 7
chrX_+_143518576 0.929 ENSMUST00000033640.7
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr17_+_35059035 0.875 ENSMUST00000007255.6
ENSMUST00000174493.1
 Ddah2

dimethylarginine dimethylaminohydrolase 2

chr16_-_50432340 0.768 ENSMUST00000066037.6
ENSMUST00000089399.4
ENSMUST00000089404.3
ENSMUST00000114477.1
ENSMUST00000138166.1
 Bbx




bobby sox homolog (Drosophila)




chr2_-_72986716 0.665 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr5_+_90794530 0.625 ENSMUST00000031322.6
 Cxcl15
chemokine (C-X-C motif) ligand 15
chr13_+_21717626 0.534 ENSMUST00000091754.2
 Hist1h3h
histone cluster 1, H3h
chr4_-_82850721 0.500 ENSMUST00000139401.1
 Zdhhc21
zinc finger, DHHC domain containing 21
chr5_+_32863700 0.493 ENSMUST00000149350.1
ENSMUST00000118698.1
ENSMUST00000150130.1
ENSMUST00000087897.4
ENSMUST00000119705.1
ENSMUST00000125574.1
ENSMUST00000049780.6
 Depdc5






DEP domain containing 5






chr11_-_121204626 0.489 ENSMUST00000026169.6
 Ogfod3
2-oxoglutarate and iron-dependent oxygenase domain containing 3
chr11_-_45955183 0.459 ENSMUST00000109254.1
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr11_-_89418948 0.429 ENSMUST00000050983.1
 4932411E22Rik
RIKEN cDNA 4932411E22 gene
chr9_-_39604124 0.400 ENSMUST00000042485.4
ENSMUST00000141370.1
 AW551984

expressed sequence AW551984

chr2_-_129371131 0.373 ENSMUST00000028881.7
 Il1b
interleukin 1 beta
chr13_+_23752267 0.368 ENSMUST00000091703.2
 Hist1h3b
histone cluster 1, H3b
chr1_-_172027251 0.301 ENSMUST00000138714.1
 Vangl2
vang-like 2 (van gogh, Drosophila)
chr11_+_117115133 0.206 ENSMUST00000021177.8
 Sec14l1
SEC14-like 1 (S. cerevisiae)
chr11_+_95666957 0.129 ENSMUST00000125172.1
ENSMUST00000036374.5
 Phb

prohibitin

chrX_-_21089229 0.063 ENSMUST00000040667.6
 Zfp300
zinc finger protein 300

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.8 52.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
4.9 14.8 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
4.7 14.2 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
1.8 9.0 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
1.8 7.2 GO:0006166 purine ribonucleoside salvage(GO:0006166)
1.6 7.9 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918)
1.2 2.4 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.9 6.5 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.9 4.5 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) prolactin signaling pathway(GO:0038161)
0.6 4.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.6 2.3 GO:0006547 histidine metabolic process(GO:0006547)
0.5 1.9 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.5 15.0 GO:0006270 DNA replication initiation(GO:0006270)
0.4 1.3 GO:0002295 T-helper cell lineage commitment(GO:0002295)
0.4 21.1 GO:0021884 forebrain neuron development(GO:0021884)
0.3 5.9 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.2 1.3 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2 4.6 GO:0097352 autophagosome maturation(GO:0097352)
0.2 6.2 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.2 2.8 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.2 3.0 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 2.2 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 0.4 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.1 1.1 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.1 1980.6 GO:0008150 biological_process(GO:0008150)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 21.1 GO:0001674 female germ cell nucleus(GO:0001674)
1.2 4.7 GO:0032021 NELF complex(GO:0032021)
1.0 5.9 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.9 14.8 GO:0042101 T cell receptor complex(GO:0042101)
0.6 9.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 1.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.4 4.1 GO:0001739 sex chromatin(GO:0001739)
0.3 6.5 GO:0071564 npBAF complex(GO:0071564)
0.2 1.7 GO:0005638 lamin filament(GO:0005638)
0.2 11.0 GO:0005876 spindle microtubule(GO:0005876)
0.2 2.2 GO:0031105 septin complex(GO:0031105)
0.2 2.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 1.9 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.5 GO:1990130 Iml1 complex(GO:1990130)
0.1 1.0 GO:0030478 actin cap(GO:0030478)
0.1 2067.0 GO:0005575 cellular_component(GO:0005575)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.8 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
4.7 14.2 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
2.4 7.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
2.3 9.0 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.7 5.9 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.7 7.9 GO:0003680 AT DNA binding(GO:0003680)
0.6 1.9 GO:0043532 angiostatin binding(GO:0043532)
0.6 11.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.5 9.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.5 4.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.3 2.7 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.3 1.3 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.2 2.8 GO:0070403 NAD+ binding(GO:0070403)
0.2 36.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 1.0 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 1.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 4.5 GO:0017046 peptide hormone binding(GO:0017046)
0.1 1.1 GO:0008097 5S rRNA binding(GO:0008097)
0.1 2038.4 GO:0003674 molecular_function(GO:0003674)