Motif ID: Hes1

Z-value: 1.568


Transcription factors associated with Hes1:

Gene SymbolEntrez IDGene Name
Hes1 ENSMUSG00000022528.7 Hes1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes1mm10_v2_chr16_+_30065333_300653510.755.2e-14Click!


Activity profile for motif Hes1.

activity profile for motif Hes1


Sorted Z-values histogram for motif Hes1

Sorted Z-values for motif Hes1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 62.264 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 58.366 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr17_-_25797032 24.772 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr14_-_79301623 20.299 ENSMUST00000022595.7
 Rgcc
regulator of cell cycle
chr4_+_154960915 20.234 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr11_-_89302545 14.887 ENSMUST00000061728.3
 Nog
noggin
chr4_+_65124174 12.519 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr8_+_71406003 12.517 ENSMUST00000119976.1
ENSMUST00000120725.1
 Ankle1

ankyrin repeat and LEM domain containing 1

chr7_+_45017953 11.504 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr2_+_156840966 11.077 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr1_-_189688074 11.003 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr8_+_119446719 10.460 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr19_-_24555819 10.145 ENSMUST00000112673.2
ENSMUST00000025800.8
 Pip5k1b

phosphatidylinositol-4-phosphate 5-kinase, type 1 beta

chr1_+_153652943 10.119 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr11_-_102925086 9.783 ENSMUST00000021311.9
 Kif18b
kinesin family member 18B
chr6_+_124829540 9.570 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr19_+_60144682 9.453 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr2_+_72476225 9.387 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr4_-_58553553 9.318 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chr11_+_72042455 8.985 ENSMUST00000021164.3
 Fam64a
family with sequence similarity 64, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
13.4 120.6 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
5.3 21.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
5.1 20.3 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
5.1 20.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.2 18.9 GO:0050772 positive regulation of axonogenesis(GO:0050772)
3.7 14.9 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
4.8 14.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
3.6 14.2 GO:0003360 brainstem development(GO:0003360)
0.2 11.5 GO:0060325 face morphogenesis(GO:0060325)
0.2 11.5 GO:0051384 response to glucocorticoid(GO:0051384)
0.6 11.1 GO:0038092 nodal signaling pathway(GO:0038092)
0.3 11.0 GO:0021591 ventricular system development(GO:0021591)
0.0 10.4 GO:0007067 mitotic nuclear division(GO:0007067)
1.5 10.2 GO:0001842 neural fold formation(GO:0001842)
0.8 10.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.9 9.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
4.4 8.8 GO:0035910 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
1.4 8.6 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.3 8.4 GO:0009409 response to cold(GO:0009409)
2.7 8.2 GO:0018298 protein-chromophore linkage(GO:0018298)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 46.4 GO:0005615 extracellular space(GO:0005615)
0.0 39.6 GO:0005829 cytosol(GO:0005829)
0.1 30.2 GO:0005815 microtubule organizing center(GO:0005815)
0.2 22.8 GO:0030139 endocytic vesicle(GO:0030139)
0.0 14.7 GO:0005667 transcription factor complex(GO:0005667)
4.7 14.2 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.8 11.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 10.9 GO:0005719 nuclear euchromatin(GO:0005719)
1.1 10.1 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.3 10.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 10.0 GO:0008180 COP9 signalosome(GO:0008180)
1.6 9.8 GO:0000235 astral microtubule(GO:0000235)
0.7 9.1 GO:0035686 sperm fibrous sheath(GO:0035686)
2.2 8.8 GO:0090537 CERF complex(GO:0090537)
0.1 8.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 8.3 GO:0005730 nucleolus(GO:0005730)
0.0 8.0 GO:0005925 focal adhesion(GO:0005925)
0.4 7.7 GO:0016580 Sin3 complex(GO:0016580)
1.5 7.6 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 7.3 GO:0022626 cytosolic ribosome(GO:0022626)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.5 120.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 31.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 26.8 GO:0033613 activating transcription factor binding(GO:0033613)
3.6 21.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.6 20.3 GO:0070412 R-SMAD binding(GO:0070412)
0.2 14.9 GO:0019955 cytokine binding(GO:0019955)
2.4 14.2 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.9 13.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 11.5 GO:0019003 GDP binding(GO:0019003)
0.3 11.0 GO:0045502 dynein binding(GO:0045502)
1.3 10.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.3 10.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 9.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 9.3 GO:0001047 core promoter binding(GO:0001047)
1.5 9.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
2.9 8.8 GO:0035939 microsatellite binding(GO:0035939)
0.5 8.8 GO:0051920 peroxiredoxin activity(GO:0051920)
0.3 8.3 GO:0070888 E-box binding(GO:0070888)
2.7 8.2 GO:0009881 photoreceptor activity(GO:0009881)
2.7 8.2 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)