Motif ID: Hes5_Hes7

Z-value: 1.566

Transcription factors associated with Hes5_Hes7:

Gene SymbolEntrez IDGene Name
Hes5 ENSMUSG00000048001.7 Hes5
Hes7 ENSMUSG00000023781.2 Hes7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes5mm10_v2_chr4_+_154960915_1549609300.721.7e-12Click!
Hes7mm10_v2_chr11_+_69120404_69120404-0.028.8e-01Click!


Activity profile for motif Hes5_Hes7.

activity profile for motif Hes5_Hes7


Sorted Z-values histogram for motif Hes5_Hes7

Sorted Z-values for motif Hes5_Hes7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes5_Hes7

PNG image of the network

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Top targets:


Showing 1 to 20 of 95 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 109.542 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 108.288 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr10_-_87493651 28.214 ENSMUST00000020243.7
 Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr2_+_163203072 22.982 ENSMUST00000109428.2
 Tox2
TOX high mobility group box family member 2
chr2_+_73271925 21.485 ENSMUST00000090813.5
 Sp9
trans-acting transcription factor 9
chr12_-_56536895 18.195 ENSMUST00000001536.8
 Nkx2-1
NK2 homeobox 1
chr13_+_108316332 15.560 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr13_+_108316395 15.218 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr13_+_51846673 14.704 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr12_+_109459843 13.268 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr6_+_4755327 12.361 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr15_+_72913357 11.756 ENSMUST00000166418.2
 Gm3150
predicted gene 3150
chr4_-_132757162 11.722 ENSMUST00000030709.8
 Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
chr9_-_36726374 10.743 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr9_+_64121501 10.109 ENSMUST00000118215.1
 Lctl
lactase-like
chr8_+_119446719 9.195 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr2_-_92370999 8.740 ENSMUST00000176810.1
ENSMUST00000090582.4
 Gyltl1b

glycosyltransferase-like 1B

chr5_+_128601106 7.301 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)
chr10_+_79682169 7.158 ENSMUST00000020550.5
 Cdc34
cell division cycle 34
chr8_-_87804411 6.804 ENSMUST00000165770.2
 Zfp423
zinc finger protein 423

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
24.2 217.8 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 30.7 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
9.4 28.2 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
1.5 21.4 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.2 19.1 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
6.1 18.2 GO:0021759 globus pallidus development(GO:0021759)
1.5 14.7 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.0 14.3 GO:0045944 positive regulation of transcription from RNA polymerase II promoter(GO:0045944)
2.0 13.7 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.2 12.4 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
1.7 11.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.3 11.6 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.8 10.7 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.0 9.4 GO:1901657 glycosyl compound metabolic process(GO:1901657)
0.9 7.3 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.6 6.8 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.2 6.8 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.3 6.2 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
2.0 5.9 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.3 5.8 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 186.4 GO:0005829 cytosol(GO:0005829)
0.2 28.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 17.1 GO:0005667 transcription factor complex(GO:0005667)
0.1 13.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 11.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 10.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 10.1 GO:0005903 brush border(GO:0005903)
0.8 6.8 GO:0046581 intercellular canaliculus(GO:0046581)
1.2 5.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 5.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 5.1 GO:0005581 collagen trimer(GO:0005581)
0.0 4.6 GO:0001726 ruffle(GO:0001726)
0.0 4.4 GO:0016324 apical plasma membrane(GO:0016324)
0.2 4.1 GO:0005652 nuclear lamina(GO:0005652)
0.1 3.6 GO:0090544 BAF-type complex(GO:0090544)
0.1 3.3 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 2.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.2 2.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.3 2.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.3 2.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.9 217.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.6 28.2 GO:0070888 E-box binding(GO:0070888)
0.2 21.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
4.3 21.4 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.1 18.9 GO:0005096 GTPase activator activity(GO:0005096)
1.5 18.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.3 13.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 12.4 GO:0017147 Wnt-protein binding(GO:0017147)
1.5 11.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
3.6 10.7 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.4 10.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 6.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.8 6.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 5.8 GO:0005109 frizzled binding(GO:0005109)
0.4 4.3 GO:0030274 LIM domain binding(GO:0030274)
0.1 4.3 GO:0035064 methylated histone binding(GO:0035064)
1.0 4.0 GO:0015141 succinate transmembrane transporter activity(GO:0015141)
0.0 3.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.7 3.5 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.1 3.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)