Motif ID: Hes5_Hes7
Z-value: 1.566
Transcription factors associated with Hes5_Hes7:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hes5 | ENSMUSG00000048001.7 | Hes5 |
Hes7 | ENSMUSG00000023781.2 | Hes7 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Hes5 | mm10_v2_chr4_+_154960915_154960930 | 0.72 | 1.7e-12 | Click! |
Hes7 | mm10_v2_chr11_+_69120404_69120404 | -0.02 | 8.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
24.2 | 217.8 | GO:0045719 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
9.4 | 28.2 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166) |
6.1 | 18.2 | GO:0021759 | globus pallidus development(GO:0021759) |
2.0 | 13.7 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
2.0 | 5.9 | GO:0010814 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
1.8 | 10.7 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
1.7 | 11.7 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
1.5 | 21.4 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
1.5 | 14.7 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
1.2 | 3.5 | GO:0010636 | positive regulation of mitochondrial fusion(GO:0010636) |
1.0 | 4.0 | GO:0015744 | succinate transport(GO:0015744) |
0.9 | 7.3 | GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
0.9 | 2.6 | GO:0003349 | epicardium-derived cardiac endothelial cell differentiation(GO:0003349) |
0.8 | 3.2 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
0.7 | 2.0 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
0.6 | 6.8 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
0.6 | 1.7 | GO:1903334 | positive regulation of protein folding(GO:1903334) |
0.6 | 1.7 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
0.6 | 2.2 | GO:1903416 | response to glycoside(GO:1903416) |
0.5 | 4.3 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
0.5 | 1.0 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
0.4 | 1.3 | GO:0060854 | patterning of lymph vessels(GO:0060854) |
0.4 | 5.1 | GO:0033690 | positive regulation of osteoblast proliferation(GO:0033690) |
0.3 | 6.2 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
0.3 | 11.6 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
0.3 | 1.4 | GO:0060066 | oviduct development(GO:0060066) |
0.3 | 3.3 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
0.3 | 5.8 | GO:0035115 | embryonic forelimb morphogenesis(GO:0035115) |
0.2 | 1.6 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
0.2 | 30.7 | GO:0030177 | positive regulation of Wnt signaling pathway(GO:0030177) |
0.2 | 6.8 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
0.2 | 1.1 | GO:0035413 | positive regulation of catenin import into nucleus(GO:0035413) |
0.2 | 12.4 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
0.2 | 19.1 | GO:0030326 | embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113) |
0.2 | 1.8 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
0.1 | 1.4 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
0.1 | 1.1 | GO:0007000 | nucleolus organization(GO:0007000) |
0.1 | 0.8 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
0.1 | 3.5 | GO:0006270 | DNA replication initiation(GO:0006270) |
0.1 | 2.0 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
0.1 | 0.4 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
0.1 | 0.5 | GO:1990403 | embryonic brain development(GO:1990403) |
0.1 | 2.3 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
0.1 | 2.5 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
0.1 | 0.6 | GO:0000059 | protein import into nucleus, docking(GO:0000059) |
0.0 | 0.3 | GO:0006361 | transcription initiation from RNA polymerase I promoter(GO:0006361) |
0.0 | 0.7 | GO:0043248 | proteasome assembly(GO:0043248) |
0.0 | 0.2 | GO:0009098 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
0.0 | 1.2 | GO:0014003 | oligodendrocyte development(GO:0014003) |
0.0 | 0.3 | GO:0034143 | regulation of toll-like receptor 4 signaling pathway(GO:0034143) |
0.0 | 0.6 | GO:0035108 | appendage morphogenesis(GO:0035107) limb morphogenesis(GO:0035108) |
0.0 | 9.4 | GO:1901657 | glycosyl compound metabolic process(GO:1901657) |
0.0 | 0.1 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
0.0 | 0.2 | GO:0032366 | intracellular sterol transport(GO:0032366) |
0.0 | 14.3 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter(GO:0045944) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 5.9 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.8 | 6.8 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.3 | 2.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
0.3 | 2.3 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
0.2 | 4.1 | GO:0005652 | nuclear lamina(GO:0005652) |
0.2 | 28.2 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
0.2 | 2.5 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
0.1 | 3.3 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
0.1 | 1.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.1 | 10.7 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
0.1 | 1.4 | GO:0016342 | catenin complex(GO:0016342) |
0.1 | 0.6 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
0.1 | 1.1 | GO:0070545 | PeBoW complex(GO:0070545) |
0.1 | 186.4 | GO:0005829 | cytosol(GO:0005829) |
0.1 | 3.6 | GO:0090544 | BAF-type complex(GO:0090544) |
0.1 | 11.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.1 | 10.1 | GO:0005903 | brush border(GO:0005903) |
0.1 | 13.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
0.1 | 5.1 | GO:0005581 | collagen trimer(GO:0005581) |
0.1 | 17.1 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 4.6 | GO:0001726 | ruffle(GO:0001726) |
0.0 | 0.2 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.0 | 0.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 4.4 | GO:0016324 | apical plasma membrane(GO:0016324) |
0.0 | 5.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
0.0 | 1.6 | GO:0031519 | PcG protein complex(GO:0031519) |
0.0 | 2.8 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
0.0 | 2.0 | GO:0005840 | ribosome(GO:0005840) |
0.0 | 1.4 | GO:0031514 | motile cilium(GO:0031514) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
9.9 | 217.8 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
4.3 | 21.4 | GO:0018121 | imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102) |
3.6 | 10.7 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
1.5 | 18.2 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
1.5 | 11.7 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
1.0 | 4.0 | GO:0015141 | succinate transmembrane transporter activity(GO:0015141) |
0.8 | 6.2 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
0.7 | 3.5 | GO:0008808 | cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) |
0.6 | 28.2 | GO:0070888 | E-box binding(GO:0070888) |
0.6 | 1.7 | GO:0008515 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
0.4 | 4.3 | GO:0030274 | LIM domain binding(GO:0030274) |
0.4 | 3.2 | GO:0004661 | protein geranylgeranyltransferase activity(GO:0004661) |
0.4 | 12.4 | GO:0017147 | Wnt-protein binding(GO:0017147) |
0.4 | 2.0 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
0.4 | 10.1 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
0.4 | 1.1 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
0.3 | 13.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
0.3 | 2.2 | GO:0103116 | alpha-D-galactofuranose transporter activity(GO:0103116) steroid hormone binding(GO:1990239) |
0.2 | 5.8 | GO:0005109 | frizzled binding(GO:0005109) |
0.2 | 1.1 | GO:0033192 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192) |
0.2 | 1.8 | GO:0102338 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
0.2 | 21.9 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
0.1 | 1.4 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.1 | 2.0 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
0.1 | 2.3 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.1 | 1.1 | GO:0031996 | thioesterase binding(GO:0031996) |
0.1 | 1.7 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
0.1 | 3.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.1 | 1.2 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
0.1 | 6.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.1 | 4.3 | GO:0035064 | methylated histone binding(GO:0035064) |
0.1 | 18.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.0 | 2.0 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
0.0 | 0.2 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
0.0 | 1.0 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 0.6 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
0.0 | 0.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.0 | 3.7 | GO:0008022 | protein C-terminus binding(GO:0008022) |