Motif ID: Hic2

Z-value: 1.615


Transcription factors associated with Hic2:

Gene SymbolEntrez IDGene Name
Hic2 ENSMUSG00000050240.8 Hic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hic2mm10_v2_chr16_+_17233560_17233664-0.551.0e-06Click!


Activity profile for motif Hic2.

activity profile for motif Hic2


Sorted Z-values histogram for motif Hic2

Sorted Z-values for motif Hic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_104231390 17.357 ENSMUST00000106992.3
Mapt
microtubule-associated protein tau
chr11_+_104231573 16.604 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
Mapt


microtubule-associated protein tau


chr12_+_61523889 16.194 ENSMUST00000119481.1
ENSMUST00000055815.7
Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr11_+_104231515 15.241 ENSMUST00000106993.3
Mapt
microtubule-associated protein tau
chr11_+_104231465 14.279 ENSMUST00000145227.1
Mapt
microtubule-associated protein tau
chr1_+_74854954 12.115 ENSMUST00000160379.2
Cdk5r2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr5_+_98180866 11.622 ENSMUST00000112959.1
Prdm8
PR domain containing 8
chr4_-_64046925 11.226 ENSMUST00000107377.3
Tnc
tenascin C
chr15_+_99224976 10.851 ENSMUST00000041415.3
Kcnh3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr6_+_103510874 10.521 ENSMUST00000066905.6
Chl1
cell adhesion molecule with homology to L1CAM
chr15_+_92051153 10.191 ENSMUST00000169825.1
Cntn1
contactin 1
chr5_+_81021583 9.889 ENSMUST00000121707.1
Lphn3
latrophilin 3
chr1_-_134234492 9.334 ENSMUST00000169927.1
Adora1
adenosine A1 receptor
chr1_-_56969827 9.302 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr15_-_66831625 9.224 ENSMUST00000164163.1
Sla
src-like adaptor
chr11_+_78324200 8.917 ENSMUST00000102478.3
Aldoc
aldolase C, fructose-bisphosphate
chr1_-_56978534 8.817 ENSMUST00000177282.1
Satb2
special AT-rich sequence binding protein 2
chr1_-_56969864 8.684 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr2_-_181156993 8.542 ENSMUST00000055990.7
Eef1a2
eukaryotic translation elongation factor 1 alpha 2
chr10_-_109010955 8.229 ENSMUST00000105276.1
ENSMUST00000064054.7
Syt1

synaptotagmin I


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 379 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 65.4 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
1.4 22.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.2 17.3 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
5.7 17.1 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
1.0 13.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
2.6 12.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.7 12.4 GO:0001553 luteinization(GO:0001553)
3.0 12.1 GO:0021586 pons maturation(GO:0021586)
2.8 11.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.6 10.8 GO:0045792 negative regulation of cell size(GO:0045792)
0.5 10.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.3 10.5 GO:0035640 exploration behavior(GO:0035640)
0.5 9.7 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
1.6 9.5 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.4 9.4 GO:0048266 behavioral response to pain(GO:0048266)
0.9 8.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.1 8.6 GO:1903596 regulation of gap junction assembly(GO:1903596)
2.1 8.5 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.7 8.5 GO:0045161 neuronal ion channel clustering(GO:0045161)
1.2 8.4 GO:0038171 cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.3 63.5 GO:0045298 tubulin complex(GO:0045298)
0.0 44.4 GO:0016021 integral component of membrane(GO:0016021)
0.3 36.8 GO:0000118 histone deacetylase complex(GO:0000118)
1.2 22.0 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.4 21.7 GO:0042734 presynaptic membrane(GO:0042734)
0.5 20.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.1 17.5 GO:0005614 interstitial matrix(GO:0005614)
0.2 14.5 GO:0031225 anchored component of membrane(GO:0031225)
0.6 14.3 GO:0030673 axolemma(GO:0030673)
4.0 12.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 11.6 GO:0044309 neuron spine(GO:0044309)
0.2 11.1 GO:0043198 dendritic shaft(GO:0043198)
0.6 10.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 10.7 GO:0035097 histone methyltransferase complex(GO:0035097)
0.4 10.4 GO:0032589 neuron projection membrane(GO:0032589)
0.7 10.1 GO:0043196 varicosity(GO:0043196)
0.9 9.4 GO:0031931 TORC1 complex(GO:0031931)
0.2 9.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 9.3 GO:0031012 extracellular matrix(GO:0031012)
0.3 9.1 GO:0046658 anchored component of plasma membrane(GO:0046658)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 252 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 65.7 GO:0034185 apolipoprotein binding(GO:0034185)
2.4 17.1 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.4 15.1 GO:0022839 ion gated channel activity(GO:0022839)
0.9 14.8 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.6 14.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.5 13.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.4 13.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.9 12.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.3 11.7 GO:0045499 chemorepellent activity(GO:0045499)
1.5 11.6 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
1.9 11.2 GO:0045545 syndecan binding(GO:0045545)
0.1 10.8 GO:0002020 protease binding(GO:0002020)
0.9 10.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 10.5 GO:0030552 cAMP binding(GO:0030552)
0.1 10.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.1 9.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.3 9.7 GO:0001540 beta-amyloid binding(GO:0001540)
1.6 9.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
1.3 9.3 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.5 9.0 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)