Motif ID: Hif1a

Z-value: 0.837


Transcription factors associated with Hif1a:

Gene SymbolEntrez IDGene Name
Hif1a ENSMUSG00000021109.7 Hif1a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hif1amm10_v2_chr12_+_73907904_73907970-0.779.1e-15Click!


Activity profile for motif Hif1a.

activity profile for motif Hif1a


Sorted Z-values histogram for motif Hif1a

Sorted Z-values for motif Hif1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hif1a

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_46845832 9.249 ENSMUST00000048209.9
ENSMUST00000092621.4
 Ldha

lactate dehydrogenase A

chr18_+_74442500 5.986 ENSMUST00000074157.6
 Myo5b
myosin VB
chr8_-_122551316 4.553 ENSMUST00000067252.7
 Piezo1
piezo-type mechanosensitive ion channel component 1
chr17_+_28769307 4.303 ENSMUST00000004986.6
 Mapk13
mitogen-activated protein kinase 13
chr1_+_74771886 4.059 ENSMUST00000006716.6
 Wnt6
wingless-related MMTV integration site 6
chr8_+_106893616 3.981 ENSMUST00000047629.5
 Cirh1a
cirrhosis, autosomal recessive 1A (human)
chr7_-_30973399 3.860 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr7_-_30973367 3.808 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr11_-_72411695 3.724 ENSMUST00000108500.1
ENSMUST00000050226.6
 Smtnl2

smoothelin-like 2

chr1_-_153549697 3.591 ENSMUST00000041874.7
 Npl
N-acetylneuraminate pyruvate lyase
chr10_-_78009737 3.575 ENSMUST00000020522.8
 Pfkl
phosphofructokinase, liver, B-type
chr2_+_71873224 3.557 ENSMUST00000006669.5
 Pdk1
pyruvate dehydrogenase kinase, isoenzyme 1
chr4_-_11386757 3.550 ENSMUST00000108313.1
ENSMUST00000108311.2
 Esrp1

epithelial splicing regulatory protein 1

chrX_-_93832106 3.525 ENSMUST00000045748.6
 Pdk3
pyruvate dehydrogenase kinase, isoenzyme 3
chr6_-_125165707 3.209 ENSMUST00000118875.1
 Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr2_+_27886416 3.103 ENSMUST00000028280.7
 Col5a1
collagen, type V, alpha 1
chr4_-_55532453 3.077 ENSMUST00000132746.1
ENSMUST00000107619.2
 Klf4

Kruppel-like factor 4 (gut)

chr6_-_125165576 2.996 ENSMUST00000183272.1
ENSMUST00000182052.1
ENSMUST00000182277.1
 Gapdh


glyceraldehyde-3-phosphate dehydrogenase


chr14_+_21052574 2.943 ENSMUST00000045376.9
 Adk
adenosine kinase
chr1_-_17097839 2.768 ENSMUST00000038382.4
 Jph1
junctophilin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 9.2 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.1 8.0 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
2.6 7.7 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.8 7.1 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 6.7 GO:0006413 translational initiation(GO:0006413)
0.0 6.7 GO:0071229 cellular response to acid chemical(GO:0071229)
1.6 6.2 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
1.5 6.0 GO:0032439 endosome localization(GO:0032439)
0.1 5.1 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 4.8 GO:0006364 rRNA processing(GO:0006364)
1.5 4.6 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.5 4.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 4.3 GO:0009299 mRNA transcription(GO:0009299)
0.1 4.3 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.6 4.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.4 4.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
1.2 3.7 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.4 3.6 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.4 3.6 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.4 3.6 GO:0030388 fructose 6-phosphate metabolic process(GO:0006002) fructose 1,6-bisphosphate metabolic process(GO:0030388)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 26.7 GO:0005615 extracellular space(GO:0005615)
0.7 9.2 GO:0035686 sperm fibrous sheath(GO:0035686)
1.3 7.7 GO:0061689 tricellular tight junction(GO:0061689)
0.9 6.2 GO:0097452 GAIT complex(GO:0097452)
1.0 6.0 GO:0045179 apical cortex(GO:0045179)
0.9 5.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 5.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.5 4.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.5 4.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.3 4.2 GO:0043196 varicosity(GO:0043196)
1.3 4.0 GO:0034455 t-UTP complex(GO:0034455)
1.2 3.6 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.9 3.6 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 3.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
1.0 3.1 GO:0005588 collagen type V trimer(GO:0005588)
0.1 3.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 2.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.6 2.8 GO:0030314 junctional membrane complex(GO:0030314)
0.7 2.7 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 2.4 GO:0070160 occluding junction(GO:0070160)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 9.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
2.1 8.4 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.4 7.7 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
1.8 7.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.7 6.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 6.4 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
2.1 6.2 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.1 6.0 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 5.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 5.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.4 4.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.4 4.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 4.1 GO:0005109 frizzled binding(GO:0005109)
0.1 3.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
1.2 3.7 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.9 3.6 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.9 3.6 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 3.3 GO:0004707 MAP kinase activity(GO:0004707)
0.3 3.1 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 3.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)