Motif ID: Hlx

Z-value: 0.251


Transcription factors associated with Hlx:

Gene SymbolEntrez IDGene Name
Hlx ENSMUSG00000039377.6 Hlx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hlxmm10_v2_chr1_-_184732616_1847326270.398.2e-04Click!


Activity profile for motif Hlx.

activity profile for motif Hlx


Sorted Z-values histogram for motif Hlx

Sorted Z-values for motif Hlx



Network of associatons between targets according to the STRING database.



First level regulatory network of Hlx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_143933204 2.655 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chrX_-_143933089 2.194 ENSMUST00000087313.3
 Dcx
doublecortin
chr15_-_8710409 2.157 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710734 2.105 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_62766153 1.218 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_180109192 1.014 ENSMUST00000143176.1
ENSMUST00000135056.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr7_-_45103747 0.719 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr9_+_54980880 0.624 ENSMUST00000093844.3
 Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr19_-_53944621 0.513 ENSMUST00000135402.2
 Bbip1
BBSome interacting protein 1
chr3_+_32436376 0.477 ENSMUST00000108242.1
 Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr6_+_7555053 0.474 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr7_-_34313531 0.382 ENSMUST00000108074.1
 4931406P16Rik
RIKEN cDNA 4931406P16 gene
chr17_-_50094277 0.364 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chrM_+_2743 0.160 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr19_+_53944870 0.110 ENSMUST00000025932.7
 Shoc2
soc-2 (suppressor of clear) homolog (C. elegans)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.3 4.8 GO:0021860 pyramidal neuron development(GO:0021860)
0.2 0.5 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.2 0.5 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.2 0.5 GO:2000852 regulation of corticosterone secretion(GO:2000852)
0.1 0.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.6 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 1.0 GO:0007097 nuclear migration(GO:0007097)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.3 GO:0043205 fibril(GO:0043205)
0.2 0.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.5 GO:0034464 BBSome(GO:0034464)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 0.7 GO:0019770 IgG receptor activity(GO:0019770)
0.2 4.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.5 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.1 0.6 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)