Motif ID: Hmx2

Z-value: 0.498


Transcription factors associated with Hmx2:

Gene SymbolEntrez IDGene Name
Hmx2 ENSMUSG00000050100.7 Hmx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx2mm10_v2_chr7_+_131548755_131548773-0.152.1e-01Click!


Activity profile for motif Hmx2.

activity profile for motif Hmx2


Sorted Z-values histogram for motif Hmx2

Sorted Z-values for motif Hmx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 148 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48667508 1.520 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
Otx2



orthodenticle homolog 2 (Drosophila)



chr5_-_28467093 1.437 ENSMUST00000002708.3
Shh
sonic hedgehog
chr12_+_72441852 1.337 ENSMUST00000162159.1
Lrrc9
leucine rich repeat containing 9
chr6_-_137169710 1.110 ENSMUST00000117919.1
Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr6_-_137169678 1.033 ENSMUST00000119610.1
Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr5_-_28210022 0.889 ENSMUST00000118882.1
Cnpy1
canopy 1 homolog (zebrafish)
chrM_+_7759 0.791 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr15_-_42676967 0.761 ENSMUST00000022921.5
Angpt1
angiopoietin 1
chr18_-_65939048 0.742 ENSMUST00000025396.3
Rax
retina and anterior neural fold homeobox
chr19_-_58454435 0.695 ENSMUST00000169850.1
Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr5_+_8660059 0.678 ENSMUST00000047753.4
Abcb1a
ATP-binding cassette, sub-family B (MDR/TAP), member 1A
chr7_-_37772868 0.673 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr14_+_73237891 0.665 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr18_-_34579072 0.658 ENSMUST00000079287.5
Nme5
NME/NM23 family member 5
chr12_-_98901478 0.646 ENSMUST00000065716.6
Eml5
echinoderm microtubule associated protein like 5
chr2_-_24048857 0.626 ENSMUST00000114497.1
Hnmt
histamine N-methyltransferase
chr1_+_91298354 0.624 ENSMUST00000142488.1
ENSMUST00000124832.1
ENSMUST00000147523.1
Scly


selenocysteine lyase


chr6_+_29694204 0.617 ENSMUST00000046750.7
ENSMUST00000115250.3
Tspan33

tetraspanin 33

chr13_-_92794809 0.613 ENSMUST00000022213.7
Thbs4
thrombospondin 4
chr4_-_62470868 0.603 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
Wdr31




WD repeat domain 31





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 1.4 GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) kidney smooth muscle tissue development(GO:0072194) negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.4 1.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 1.1 GO:0001887 selenium compound metabolic process(GO:0001887)
0.1 1.0 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 1.0 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 0.7 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 0.7 GO:0046036 GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.0 0.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.7 GO:0021854 hypothalamus development(GO:0021854)
0.2 0.6 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.0 0.6 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.2 0.5 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.5 GO:0006825 copper ion transport(GO:0006825)
0.0 0.5 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.5 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.0 0.5 GO:0032611 interleukin-1 beta production(GO:0032611)
0.1 0.4 GO:0045472 response to ether(GO:0045472)
0.1 0.4 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0005902 microvillus(GO:0005902)
0.1 1.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 0.6 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.5 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.4 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.3 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.1 GO:0061702 inflammasome complex(GO:0061702)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.1 GO:0043237 laminin-1 binding(GO:0043237)
0.2 1.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 1.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.8 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 0.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.5 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.5 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.4 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.3 GO:0071862 protein phosphatase type 1 activator activity(GO:0071862)
0.1 0.3 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.3 GO:0016004 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.0 0.3 GO:0008253 5'-nucleotidase activity(GO:0008253)