Motif ID: Hmx3

Z-value: 0.275


Transcription factors associated with Hmx3:

Gene SymbolEntrez IDGene Name
Hmx3 ENSMUSG00000040148.5 Hmx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx3mm10_v2_chr7_+_131542867_1315428670.133.0e-01Click!


Activity profile for motif Hmx3.

activity profile for motif Hmx3


Sorted Z-values histogram for motif Hmx3

Sorted Z-values for motif Hmx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_49757257 1.287 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr3_-_154328634 0.855 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chr13_+_118714678 0.847 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr13_-_92131494 0.764 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr10_+_99263224 0.727 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr9_-_123678782 0.595 ENSMUST00000170591.1
ENSMUST00000171647.1
 Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr5_+_15516489 0.491 ENSMUST00000178227.1
 Gm21847
predicted gene, 21847
chr2_+_3114220 0.479 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr9_-_123678873 0.468 ENSMUST00000040960.6
 Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr2_-_72986716 0.464 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chrX_+_150594420 0.460 ENSMUST00000112713.2
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr4_-_62470868 0.447 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
 Wdr31




WD repeat domain 31




chr18_+_61639542 0.390 ENSMUST00000183083.1
ENSMUST00000183087.1
 Gm20748

predicted gene, 20748

chr11_+_103133303 0.378 ENSMUST00000107037.1
 Hexim2
hexamethylene bis-acetamide inducible 2
chr4_-_129261394 0.357 ENSMUST00000145261.1
 C77080
expressed sequence C77080
chr5_-_137684665 0.354 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
 Agfg2


ArfGAP with FG repeats 2


chr7_-_126897424 0.323 ENSMUST00000120007.1
 Tmem219
transmembrane protein 219
chr5_-_87482258 0.307 ENSMUST00000079811.6
ENSMUST00000144144.1
 Ugt2a1

UDP glucuronosyltransferase 2 family, polypeptide A1

chr7_+_3645267 0.284 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr11_+_114668524 0.279 ENSMUST00000106602.3
ENSMUST00000077915.3
ENSMUST00000106599.1
ENSMUST00000082092.4
 Rpl38



ribosomal protein L38



chr19_-_41933276 0.278 ENSMUST00000075280.4
ENSMUST00000112123.2
 Exosc1

exosome component 1

chr11_+_103133333 0.267 ENSMUST00000124928.1
ENSMUST00000062530.4
 Hexim2

hexamethylene bis-acetamide inducible 2

chr4_+_144893127 0.253 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr19_+_8802486 0.253 ENSMUST00000172175.1
 Zbtb3
zinc finger and BTB domain containing 3
chr1_-_190170671 0.251 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr12_-_83487708 0.242 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr17_-_57247632 0.232 ENSMUST00000005975.6
 Gpr108
G protein-coupled receptor 108
chr2_-_84715160 0.231 ENSMUST00000035840.5
 Zdhhc5
zinc finger, DHHC domain containing 5
chr3_+_96629919 0.228 ENSMUST00000048915.6
 Rbm8a
RNA binding motif protein 8a
chr7_-_30559828 0.226 ENSMUST00000108164.1
 Lin37
lin-37 homolog (C. elegans)
chrM_+_9452 0.223 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr7_-_45510400 0.192 ENSMUST00000033096.7
 Nucb1
nucleobindin 1
chr19_+_41933464 0.187 ENSMUST00000026154.7
 Zdhhc16
zinc finger, DHHC domain containing 16
chr6_+_86371489 0.180 ENSMUST00000089558.5
 Snrpg
small nuclear ribonucleoprotein polypeptide G
chr8_-_23237623 0.173 ENSMUST00000033950.5
 Gins4
GINS complex subunit 4 (Sld5 homolog)
chr4_+_65604984 0.160 ENSMUST00000050850.7
ENSMUST00000107366.1
 Trim32

tripartite motif-containing 32

chr2_-_153015331 0.158 ENSMUST00000028972.8
 Pdrg1
p53 and DNA damage regulated 1
chr4_-_45532470 0.158 ENSMUST00000147448.1
 Shb
src homology 2 domain-containing transforming protein B
chr2_-_130424673 0.157 ENSMUST00000110277.1
 Pced1a
PC-esterase domain containing 1A
chr7_-_30559600 0.148 ENSMUST00000043975.4
ENSMUST00000156241.1
 Lin37

lin-37 homolog (C. elegans)

chr5_+_121777929 0.144 ENSMUST00000160821.1
 Atxn2
ataxin 2
chr3_+_62419668 0.143 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr13_+_23746734 0.139 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr2_+_130424321 0.136 ENSMUST00000128994.1
ENSMUST00000028900.9
 Vps16

vacuolar protein sorting 16 (yeast)

chr12_-_83921809 0.134 ENSMUST00000135962.1
ENSMUST00000155112.1
ENSMUST00000136848.1
ENSMUST00000126943.1
 Numb



numb gene homolog (Drosophila)



chrM_+_3906 0.131 ENSMUST00000082396.1
 mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr9_+_21955747 0.115 ENSMUST00000053583.5
 Swsap1
SWIM type zinc finger 7 associated protein 1
chr12_+_108179738 0.108 ENSMUST00000101055.4
 Ccnk
cyclin K
chr1_-_78968079 0.106 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr19_+_11965817 0.101 ENSMUST00000025590.9
 Osbp
oxysterol binding protein
chr3_+_66985947 0.093 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr7_+_25267669 0.080 ENSMUST00000169266.1
 Cic
capicua homolog (Drosophila)
chr6_+_92092369 0.080 ENSMUST00000113463.1
 Nr2c2
nuclear receptor subfamily 2, group C, member 2
chr10_-_80421847 0.079 ENSMUST00000156244.1
 Tcf3
transcription factor 3
chr3_+_109573907 0.065 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr7_-_127208423 0.065 ENSMUST00000120705.1
 Tbc1d10b
TBC1 domain family, member 10b
chr7_+_25681158 0.042 ENSMUST00000108403.3
 B9d2
B9 protein domain 2
chr14_-_55560340 0.042 ENSMUST00000066106.3
 A730061H03Rik
RIKEN cDNA A730061H03 gene
chr7_+_43690418 0.039 ENSMUST00000056329.6
 Klk14
kallikrein related-peptidase 14
chr12_-_108179210 0.033 ENSMUST00000125916.2
ENSMUST00000109879.1
 Setd3

SET domain containing 3

chr12_-_83921899 0.023 ENSMUST00000117217.1
 Numb
numb gene homolog (Drosophila)
chr12_-_108179237 0.011 ENSMUST00000071095.7
 Setd3
SET domain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0071336 lung growth(GO:0060437) positive regulation of fat cell proliferation(GO:0070346) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.2 0.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 1.1 GO:0036233 glycine import(GO:0036233)
0.1 0.3 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 1.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.2 GO:0030862 neuroblast division in subventricular zone(GO:0021849) regulation of polarized epithelial cell differentiation(GO:0030860) positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.1 0.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.2 GO:1903265 keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172) positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.3 GO:0048318 axial mesoderm development(GO:0048318)
0.0 0.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.8 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.3 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.2 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.6 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.9 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0002326 B cell lineage commitment(GO:0002326)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.9 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.2 GO:0000811 GINS complex(GO:0000811)
0.0 0.2 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.1 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
0.0 0.2 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)
0.0 0.2 GO:0032982 myosin filament(GO:0032982)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2 1.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.6 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.4 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)