Motif ID: Hnf1b
Z-value: 0.740
Transcription factors associated with Hnf1b:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hnf1b | ENSMUSG00000020679.5 | Hnf1b |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.2 | 6.7 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
2.0 | 5.9 | GO:0010989 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) |
1.8 | 5.5 | GO:1900158 | negative regulation of bone mineralization involved in bone maturation(GO:1900158) |
1.7 | 8.6 | GO:0007223 | Wnt signaling pathway, calcium modulating pathway(GO:0007223) |
1.7 | 5.1 | GO:1902396 | protein localization to bicellular tight junction(GO:1902396) |
1.3 | 6.7 | GO:0015705 | iodide transport(GO:0015705) |
1.2 | 3.5 | GO:0003195 | tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) |
1.0 | 3.1 | GO:0097274 | urea homeostasis(GO:0097274) |
0.8 | 4.1 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
0.8 | 4.0 | GO:0072757 | cellular response to camptothecin(GO:0072757) |
0.7 | 3.3 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
0.6 | 2.5 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
0.6 | 1.8 | GO:0007521 | muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596) |
0.6 | 1.7 | GO:0050787 | glycolate metabolic process(GO:0009441) enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) detoxification of mercury ion(GO:0050787) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) glyoxal catabolic process(GO:1903190) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284) positive regulation of androgen receptor activity(GO:2000825) |
0.5 | 4.1 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
0.5 | 3.1 | GO:0098700 | aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700) |
0.5 | 5.7 | GO:0034383 | low-density lipoprotein particle clearance(GO:0034383) |
0.5 | 2.7 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.4 | 1.3 | GO:0060392 | negative regulation of SMAD protein import into nucleus(GO:0060392) |
0.4 | 6.1 | GO:0042178 | xenobiotic catabolic process(GO:0042178) |
0.4 | 1.1 | GO:1902369 | negative regulation of RNA catabolic process(GO:1902369) |
0.4 | 2.8 | GO:0036462 | TRAIL-activated apoptotic signaling pathway(GO:0036462) |
0.3 | 3.5 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
0.3 | 1.2 | GO:0050748 | negative regulation of lipoprotein metabolic process(GO:0050748) |
0.3 | 8.1 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity(GO:2000651) |
0.3 | 1.7 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
0.3 | 1.5 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
0.2 | 1.1 | GO:1904721 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
0.2 | 1.2 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
0.2 | 1.1 | GO:0046689 | response to mercury ion(GO:0046689) |
0.2 | 0.5 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) |
0.2 | 0.7 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
0.2 | 5.5 | GO:0072698 | protein localization to microtubule cytoskeleton(GO:0072698) |
0.2 | 1.4 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
0.2 | 3.5 | GO:0006825 | copper ion transport(GO:0006825) |
0.1 | 1.3 | GO:0018095 | protein polyglutamylation(GO:0018095) |
0.1 | 1.2 | GO:0090400 | stress-induced premature senescence(GO:0090400) |
0.1 | 0.4 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
0.1 | 0.9 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
0.1 | 0.8 | GO:0052695 | cellular glucuronidation(GO:0052695) |
0.1 | 1.5 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
0.1 | 1.0 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
0.1 | 0.5 | GO:0044830 | modulation by host of viral RNA genome replication(GO:0044830) |
0.1 | 0.6 | GO:0036112 | medium-chain fatty-acyl-CoA metabolic process(GO:0036112) |
0.1 | 0.7 | GO:0033147 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147) |
0.1 | 4.8 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
0.1 | 0.3 | GO:0015886 | heme transport(GO:0015886) |
0.1 | 0.6 | GO:0046415 | urate metabolic process(GO:0046415) |
0.1 | 3.3 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
0.1 | 1.0 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
0.1 | 1.2 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
0.1 | 1.5 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
0.0 | 0.7 | GO:0010225 | response to UV-C(GO:0010225) |
0.0 | 0.1 | GO:1904956 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) |
0.0 | 4.9 | GO:0045727 | positive regulation of translation(GO:0045727) |
0.0 | 1.6 | GO:0006414 | translational elongation(GO:0006414) |
0.0 | 0.7 | GO:0043968 | histone H2A acetylation(GO:0043968) |
0.0 | 0.1 | GO:0021691 | cerebellar Purkinje cell layer maturation(GO:0021691) |
0.0 | 0.9 | GO:0010107 | potassium ion import(GO:0010107) |
0.0 | 0.1 | GO:0060971 | embryonic heart tube left/right pattern formation(GO:0060971) |
0.0 | 1.6 | GO:0010718 | positive regulation of epithelial to mesenchymal transition(GO:0010718) |
0.0 | 0.2 | GO:0002553 | histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) |
0.0 | 3.8 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
0.0 | 0.1 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
0.0 | 0.3 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
0.0 | 0.4 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
0.0 | 2.7 | GO:0098780 | mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780) |
0.0 | 0.2 | GO:0015868 | purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868) |
0.0 | 0.2 | GO:0034472 | snRNA 3'-end processing(GO:0034472) |
0.0 | 0.4 | GO:0007608 | sensory perception of smell(GO:0007608) |
0.0 | 3.8 | GO:0042384 | cilium assembly(GO:0042384) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.0 | 5.9 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
1.4 | 5.7 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
0.9 | 2.8 | GO:0030690 | Noc1p-Noc2p complex(GO:0030690) |
0.5 | 1.5 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
0.5 | 5.5 | GO:0097431 | mitotic spindle pole(GO:0097431) |
0.3 | 5.1 | GO:0031143 | pseudopodium(GO:0031143) |
0.3 | 1.2 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
0.3 | 4.1 | GO:0031528 | microvillus membrane(GO:0031528) |
0.2 | 1.4 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
0.2 | 3.3 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
0.2 | 3.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
0.2 | 0.7 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
0.2 | 3.5 | GO:0016580 | Sin3 complex(GO:0016580) |
0.2 | 6.7 | GO:0034707 | chloride channel complex(GO:0034707) |
0.1 | 3.0 | GO:0010369 | chromocenter(GO:0010369) |
0.1 | 0.7 | GO:0070826 | paraferritin complex(GO:0070826) |
0.1 | 0.9 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
0.1 | 2.5 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
0.1 | 3.8 | GO:0043034 | costamere(GO:0043034) |
0.1 | 9.7 | GO:0005814 | centriole(GO:0005814) |
0.1 | 1.2 | GO:0032156 | septin cytoskeleton(GO:0032156) |
0.1 | 5.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
0.1 | 0.7 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
0.1 | 2.8 | GO:0044295 | axonal growth cone(GO:0044295) |
0.0 | 1.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
0.0 | 0.1 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
0.0 | 0.7 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
0.0 | 6.2 | GO:0000139 | Golgi membrane(GO:0000139) |
0.0 | 7.8 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 4.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
0.0 | 1.5 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
0.0 | 1.1 | GO:0036126 | sperm flagellum(GO:0036126) |
0.0 | 0.2 | GO:0005922 | connexon complex(GO:0005922) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.0 | 5.9 | GO:0034190 | apolipoprotein receptor binding(GO:0034190) |
1.7 | 6.7 | GO:0001733 | galactosylceramide sulfotransferase activity(GO:0001733) |
1.7 | 6.7 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
1.2 | 3.5 | GO:0035939 | microsatellite binding(GO:0035939) |
0.8 | 2.5 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.8 | 3.1 | GO:0036468 | aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468) |
0.7 | 2.8 | GO:0035877 | death effector domain binding(GO:0035877) |
0.6 | 5.7 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
0.6 | 4.1 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
0.6 | 1.7 | GO:0044388 | tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) small protein activating enzyme binding(GO:0044388) cupric ion binding(GO:1903135) cuprous ion binding(GO:1903136) glyoxalase (glycolic acid-forming) activity(GO:1990422) |
0.6 | 2.8 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
0.3 | 5.5 | GO:0031005 | filamin binding(GO:0031005) |
0.3 | 6.1 | GO:0070402 | NADPH binding(GO:0070402) |
0.3 | 1.5 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
0.3 | 8.6 | GO:0017147 | Wnt-protein binding(GO:0017147) |
0.3 | 4.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.2 | 3.3 | GO:0005537 | mannose binding(GO:0005537) |
0.2 | 3.1 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
0.2 | 1.1 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
0.2 | 0.6 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
0.2 | 3.3 | GO:0008143 | poly(A) binding(GO:0008143) poly(U) RNA binding(GO:0008266) |
0.2 | 5.2 | GO:0030371 | translation repressor activity(GO:0030371) |
0.2 | 0.9 | GO:0034235 | GPI anchor binding(GO:0034235) |
0.2 | 0.6 | GO:0047760 | butyrate-CoA ligase activity(GO:0047760) |
0.1 | 3.1 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.1 | 0.7 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
0.1 | 0.9 | GO:0015265 | urea channel activity(GO:0015265) |
0.1 | 0.4 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
0.1 | 1.7 | GO:0015149 | glucose transmembrane transporter activity(GO:0005355) hexose transmembrane transporter activity(GO:0015149) |
0.1 | 1.6 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
0.1 | 1.4 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
0.1 | 0.7 | GO:0001226 | RNA polymerase II transcription corepressor binding(GO:0001226) |
0.1 | 5.1 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
0.1 | 5.5 | GO:0019894 | kinesin binding(GO:0019894) |
0.1 | 5.5 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
0.1 | 0.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.1 | 0.3 | GO:0015232 | heme transporter activity(GO:0015232) |
0.1 | 1.2 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.0 | 0.7 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.0 | 0.9 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
0.0 | 0.2 | GO:1990460 | leptin receptor binding(GO:1990460) |
0.0 | 2.7 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
0.0 | 0.7 | GO:0097602 | cullin family protein binding(GO:0097602) |
0.0 | 0.4 | GO:0034951 | pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011) |
0.0 | 0.1 | GO:0048019 | receptor antagonist activity(GO:0048019) |
0.0 | 1.0 | GO:0051059 | NF-kappaB binding(GO:0051059) |
0.0 | 0.1 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
0.0 | 1.2 | GO:0004497 | monooxygenase activity(GO:0004497) |
0.0 | 1.5 | GO:0008186 | ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
0.0 | 3.8 | GO:0051015 | actin filament binding(GO:0051015) |
0.0 | 1.2 | GO:0016209 | antioxidant activity(GO:0016209) |
0.0 | 7.5 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
0.0 | 1.2 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
0.0 | 0.2 | GO:0005243 | gap junction channel activity(GO:0005243) |
0.0 | 1.5 | GO:0043130 | ubiquitin binding(GO:0043130) |
0.0 | 0.5 | GO:0048487 | beta-tubulin binding(GO:0048487) |
0.0 | 0.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |