Motif ID: Hoxa11_Hoxc12
Z-value: 1.114
Transcription factors associated with Hoxa11_Hoxc12:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hoxa11 | ENSMUSG00000038210.9 | Hoxa11 |
Hoxc12 | ENSMUSG00000050328.2 | Hoxc12 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.2 | 6.6 | GO:0009405 | pathogenesis(GO:0009405) |
2.0 | 9.9 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
1.9 | 5.6 | GO:0072092 | ureteric bud invasion(GO:0072092) metanephric renal vesicle formation(GO:0072093) |
1.8 | 7.1 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
1.7 | 5.2 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
1.7 | 10.1 | GO:0042045 | epithelial fluid transport(GO:0042045) |
1.2 | 12.9 | GO:0023041 | neuronal signal transduction(GO:0023041) |
1.2 | 18.7 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
1.0 | 3.1 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
1.0 | 4.0 | GO:0072362 | regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362) |
0.8 | 22.5 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
0.7 | 4.7 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
0.7 | 3.3 | GO:0030242 | pexophagy(GO:0030242) |
0.7 | 2.0 | GO:0043201 | response to leucine(GO:0043201) cellular response to leucine(GO:0071233) |
0.6 | 4.8 | GO:0070314 | G1 to G0 transition(GO:0070314) |
0.5 | 9.6 | GO:0021542 | dentate gyrus development(GO:0021542) |
0.5 | 1.8 | GO:1990743 | protein sialylation(GO:1990743) |
0.5 | 4.6 | GO:0042118 | endothelial cell activation(GO:0042118) |
0.4 | 2.6 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
0.4 | 3.1 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
0.4 | 5.6 | GO:0051764 | actin crosslink formation(GO:0051764) |
0.4 | 8.4 | GO:0043030 | regulation of macrophage activation(GO:0043030) |
0.4 | 1.8 | GO:0051189 | Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189) |
0.4 | 1.4 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
0.3 | 0.9 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
0.3 | 2.3 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
0.3 | 2.5 | GO:0030035 | microspike assembly(GO:0030035) |
0.3 | 1.6 | GO:0002317 | plasma cell differentiation(GO:0002317) |
0.3 | 1.8 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
0.3 | 1.8 | GO:0090527 | actin filament reorganization(GO:0090527) |
0.2 | 10.1 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
0.2 | 1.7 | GO:0045213 | neurotransmitter receptor metabolic process(GO:0045213) |
0.2 | 1.4 | GO:0045448 | regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448) |
0.2 | 0.9 | GO:0010936 | negative regulation of macrophage cytokine production(GO:0010936) |
0.2 | 2.9 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.2 | 2.3 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
0.2 | 6.8 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
0.2 | 1.3 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
0.2 | 9.1 | GO:0032755 | positive regulation of interleukin-6 production(GO:0032755) |
0.2 | 1.5 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
0.2 | 3.8 | GO:0015813 | L-glutamate transport(GO:0015813) |
0.1 | 1.7 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
0.1 | 15.7 | GO:0098792 | xenophagy(GO:0098792) |
0.1 | 3.5 | GO:0097320 | membrane tubulation(GO:0097320) |
0.1 | 2.4 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
0.1 | 0.7 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
0.1 | 1.0 | GO:0071361 | cellular response to ethanol(GO:0071361) |
0.1 | 0.7 | GO:0015808 | L-alanine transport(GO:0015808) |
0.1 | 1.1 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
0.1 | 2.8 | GO:0010591 | regulation of lamellipodium assembly(GO:0010591) |
0.1 | 1.2 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
0.1 | 0.3 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
0.0 | 1.2 | GO:0048246 | macrophage chemotaxis(GO:0048246) |
0.0 | 0.8 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
0.0 | 1.4 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
0.0 | 0.2 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
0.0 | 5.1 | GO:0031032 | actomyosin structure organization(GO:0031032) |
0.0 | 1.2 | GO:0048747 | muscle fiber development(GO:0048747) |
0.0 | 1.0 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
0.0 | 6.3 | GO:0006914 | autophagy(GO:0006914) |
0.0 | 0.2 | GO:0046834 | lipid phosphorylation(GO:0046834) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.4 | 10.1 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
3.3 | 9.9 | GO:0043512 | inhibin A complex(GO:0043512) |
1.0 | 3.1 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
0.7 | 10.1 | GO:0042581 | specific granule(GO:0042581) |
0.6 | 6.8 | GO:0043083 | synaptic cleft(GO:0043083) |
0.3 | 12.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
0.3 | 3.5 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
0.2 | 3.1 | GO:0045095 | keratin filament(GO:0045095) |
0.2 | 0.7 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
0.2 | 22.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.2 | 7.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
0.2 | 1.8 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
0.2 | 1.7 | GO:0030008 | TRAPP complex(GO:0030008) |
0.2 | 5.2 | GO:0030673 | axolemma(GO:0030673) |
0.1 | 1.4 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
0.1 | 5.6 | GO:0031941 | filamentous actin(GO:0031941) |
0.1 | 1.1 | GO:0030057 | desmosome(GO:0030057) |
0.1 | 8.4 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
0.1 | 1.8 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.1 | 0.4 | GO:0031084 | BLOC-2 complex(GO:0031084) |
0.1 | 1.1 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
0.1 | 6.1 | GO:0032587 | ruffle membrane(GO:0032587) |
0.1 | 2.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.1 | 0.2 | GO:0031417 | NatC complex(GO:0031417) |
0.0 | 21.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
0.0 | 1.5 | GO:0034707 | chloride channel complex(GO:0034707) |
0.0 | 2.5 | GO:0030175 | filopodium(GO:0030175) |
0.0 | 1.0 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
0.0 | 2.0 | GO:0000502 | proteasome complex(GO:0000502) |
0.0 | 9.3 | GO:0005874 | microtubule(GO:0005874) |
0.0 | 0.9 | GO:0045335 | phagocytic vesicle(GO:0045335) |
0.0 | 2.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
0.0 | 1.8 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
0.0 | 1.8 | GO:0030427 | site of polarized growth(GO:0030427) |
0.0 | 1.4 | GO:0016607 | nuclear speck(GO:0016607) |
0.0 | 4.4 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
0.0 | 3.8 | GO:0000790 | nuclear chromatin(GO:0000790) |
0.0 | 1.6 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
7.5 | 22.5 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
3.4 | 10.1 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
1.8 | 7.1 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
1.6 | 9.9 | GO:0070699 | type II activin receptor binding(GO:0070699) |
1.4 | 5.6 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
1.1 | 4.6 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
1.0 | 6.8 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
0.7 | 6.6 | GO:0015643 | toxic substance binding(GO:0015643) |
0.7 | 2.6 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
0.6 | 5.2 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
0.5 | 4.0 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
0.4 | 3.1 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) |
0.4 | 2.3 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
0.4 | 5.6 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
0.4 | 1.8 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
0.3 | 6.8 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
0.3 | 12.9 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.3 | 2.0 | GO:0070728 | leucine binding(GO:0070728) |
0.3 | 4.7 | GO:0042608 | T cell receptor binding(GO:0042608) |
0.2 | 0.7 | GO:0015173 | hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173) |
0.2 | 1.0 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
0.2 | 1.5 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
0.2 | 10.1 | GO:0045296 | cadherin binding(GO:0045296) |
0.2 | 2.3 | GO:0102338 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
0.2 | 3.8 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
0.1 | 0.7 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
0.1 | 1.4 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.1 | 1.4 | GO:0035497 | cAMP response element binding(GO:0035497) |
0.1 | 1.3 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
0.1 | 2.4 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
0.1 | 1.4 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
0.1 | 1.4 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
0.1 | 8.7 | GO:0030165 | PDZ domain binding(GO:0030165) |
0.1 | 2.9 | GO:0004120 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715) |
0.1 | 8.4 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
0.0 | 1.2 | GO:0008009 | chemokine activity(GO:0008009) |
0.0 | 1.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
0.0 | 2.8 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
0.0 | 1.7 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.0 | 0.6 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.0 | 1.6 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
0.0 | 8.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
0.0 | 1.2 | GO:0051059 | NF-kappaB binding(GO:0051059) |
0.0 | 1.8 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
0.0 | 2.2 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
0.0 | 2.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.0 | 0.2 | GO:0001727 | lipid kinase activity(GO:0001727) |
0.0 | 5.2 | GO:0008017 | microtubule binding(GO:0008017) |
0.0 | 1.8 | GO:0032947 | protein complex scaffold(GO:0032947) |
0.0 | 2.0 | GO:0051219 | phosphoprotein binding(GO:0051219) |
0.0 | 6.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
0.0 | 0.2 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
0.0 | 9.8 | GO:0003682 | chromatin binding(GO:0003682) |
0.0 | 3.1 | GO:0005198 | structural molecule activity(GO:0005198) |
0.0 | 0.2 | GO:0010181 | FMN binding(GO:0010181) |