Motif ID: Hoxa9_Hoxb9

Z-value: 0.448

Transcription factors associated with Hoxa9_Hoxb9:

Gene SymbolEntrez IDGene Name
Hoxa9 ENSMUSG00000038227.9 Hoxa9
Hoxb9 ENSMUSG00000020875.8 Hoxb9






Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa9_Hoxb9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_57197435 4.663 ENSMUST00000111550.1
Ablim1
actin-binding LIM protein 1
chr19_-_57197377 4.548 ENSMUST00000111546.1
Ablim1
actin-binding LIM protein 1
chr3_+_108591279 4.154 ENSMUST00000051145.8
ENSMUST00000139626.1
Wdr47

WD repeat domain 47

chr6_+_49822710 4.085 ENSMUST00000031843.6
Npy
neuropeptide Y
chr1_+_194619815 2.852 ENSMUST00000027952.5
Plxna2
plexin A2
chr18_-_31447383 2.463 ENSMUST00000025110.3
Syt4
synaptotagmin IV
chr17_-_91092715 2.053 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I


chr8_+_93810832 2.019 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr13_+_16014457 2.015 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr19_-_57197496 2.007 ENSMUST00000111544.1
Ablim1
actin-binding LIM protein 1
chr19_-_57197556 1.846 ENSMUST00000099294.2
Ablim1
actin-binding LIM protein 1
chr18_+_37400845 1.722 ENSMUST00000057228.1
Pcdhb9
protocadherin beta 9
chrX_+_159840463 1.596 ENSMUST00000112451.1
ENSMUST00000112453.2
Sh3kbp1

SH3-domain kinase binding protein 1

chr15_+_81936753 1.570 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chr15_+_81936911 1.553 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr7_+_28277706 1.503 ENSMUST00000094651.2
Eid2b
EP300 interacting inhibitor of differentiation 2B
chr19_-_45812291 1.467 ENSMUST00000086993.4
Kcnip2
Kv channel-interacting protein 2
chr2_-_33087169 1.389 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr11_-_109298066 1.340 ENSMUST00000106706.1
Rgs9
regulator of G-protein signaling 9
chr2_-_33086366 1.278 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr16_-_52454074 1.278 ENSMUST00000023312.7
Alcam
activated leukocyte cell adhesion molecule
chr2_+_125136692 1.236 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr1_+_66386968 1.236 ENSMUST00000145419.1
Map2
microtubule-associated protein 2
chr18_-_31317043 1.234 ENSMUST00000139924.1
ENSMUST00000153060.1
Rit2

Ras-like without CAAX 2

chr8_+_112570043 1.230 ENSMUST00000034225.6
ENSMUST00000118171.1
Cntnap4

contactin associated protein-like 4

chr2_-_31845925 1.188 ENSMUST00000028188.7
Fibcd1
fibrinogen C domain containing 1
chr4_+_74013442 1.173 ENSMUST00000098006.2
ENSMUST00000084474.5
Frmd3

FERM domain containing 3

chr2_-_45112890 1.163 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr7_+_56050135 1.055 ENSMUST00000076226.6
Herc2
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2
chr3_+_138065052 0.989 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr4_-_49597860 0.960 ENSMUST00000042750.2
Tmem246
transmembrane protein 246
chr9_+_121366958 0.921 ENSMUST00000045903.6
Trak1
trafficking protein, kinesin binding 1
chr5_-_73191848 0.903 ENSMUST00000176910.1
Fryl
furry homolog-like (Drosophila)
chr2_+_32395896 0.884 ENSMUST00000028162.3
Ptges2
prostaglandin E synthase 2
chr11_-_79504078 0.853 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chr5_-_145201829 0.837 ENSMUST00000162220.1
ENSMUST00000031632.8
Zkscan14

zinc finger with KRAB and SCAN domains 14

chr3_-_113574242 0.829 ENSMUST00000142505.2
Amy1
amylase 1, salivary
chr15_-_79062866 0.779 ENSMUST00000151889.1
ENSMUST00000040676.4
Ankrd54

ankyrin repeat domain 54

chr2_+_28205648 0.763 ENSMUST00000102879.3
ENSMUST00000028177.4
Olfm1

olfactomedin 1

chr6_-_143947092 0.760 ENSMUST00000144289.1
ENSMUST00000111748.1
Sox5

SRY-box containing gene 5

chr5_-_66514815 0.754 ENSMUST00000161879.1
ENSMUST00000159357.1
Apbb2

amyloid beta (A4) precursor protein-binding, family B, member 2

chr7_-_127449109 0.748 ENSMUST00000053392.4
Zfp689
zinc finger protein 689
chr7_-_127448993 0.748 ENSMUST00000106299.1
Zfp689
zinc finger protein 689
chr6_-_143947061 0.730 ENSMUST00000124233.1
Sox5
SRY-box containing gene 5
chr17_-_6621267 0.724 ENSMUST00000115772.3
Tmem181c-ps
transmembrane protein 181C, pseudogene
chr5_-_32746317 0.686 ENSMUST00000135248.1
Pisd
phosphatidylserine decarboxylase
chr9_-_101198999 0.686 ENSMUST00000066773.7
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr7_-_141434532 0.681 ENSMUST00000133021.1
ENSMUST00000106007.3
ENSMUST00000150026.1
ENSMUST00000133206.2
Slc25a22



solute carrier family 25 (mitochondrial carrier, glutamate), member 22



chr3_+_98280427 0.629 ENSMUST00000090746.2
ENSMUST00000120541.1
Hmgcs2

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2

chr1_+_89454769 0.627 ENSMUST00000027521.8
ENSMUST00000074945.5
Agap1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr4_+_44012661 0.617 ENSMUST00000107849.3
ENSMUST00000107851.3
ENSMUST00000107845.3
Clta


clathrin, light polypeptide (Lca)


chr14_+_20674311 0.575 ENSMUST00000048657.8
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr7_+_28693997 0.556 ENSMUST00000108280.1
Fbxo27
F-box protein 27
chr3_+_32436376 0.538 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr11_-_109298090 0.509 ENSMUST00000106704.2
Rgs9
regulator of G-protein signaling 9
chr6_+_51523901 0.508 ENSMUST00000049152.8
Snx10
sorting nexin 10
chr4_+_44012638 0.488 ENSMUST00000107847.3
ENSMUST00000170241.1
Clta

clathrin, light polypeptide (Lca)

chr10_-_80590292 0.471 ENSMUST00000003436.5
Abhd17a
abhydrolase domain containing 17A
chr13_-_91388079 0.471 ENSMUST00000181054.1
A830009L08Rik
RIKEN cDNA A830009L08 gene
chr17_-_15826521 0.430 ENSMUST00000170578.1
Rgmb
RGM domain family, member B
chr9_+_75311395 0.428 ENSMUST00000076889.6
Gnb5
guanine nucleotide binding protein (G protein), beta 5
chr4_+_144893127 0.411 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr2_+_180967291 0.405 ENSMUST00000108859.1
Arfgap1
ADP-ribosylation factor GTPase activating protein 1
chr9_+_64235201 0.386 ENSMUST00000039011.3
Uchl4
ubiquitin carboxyl-terminal esterase L4
chr7_-_30232186 0.386 ENSMUST00000006254.5
Tbcb
tubulin folding cofactor B
chr19_+_44203265 0.385 ENSMUST00000026220.5
Scd3
stearoyl-coenzyme A desaturase 3
chr17_+_33638056 0.368 ENSMUST00000052079.7
Pram1
PML-RAR alpha-regulated adaptor molecule 1
chr19_-_7341848 0.365 ENSMUST00000171393.1
Mark2
MAP/microtubule affinity-regulating kinase 2
chr2_-_27463994 0.365 ENSMUST00000164296.1
Brd3
bromodomain containing 3
chr5_-_107869153 0.358 ENSMUST00000128723.1
ENSMUST00000124034.1
Evi5

ecotropic viral integration site 5

chr10_-_63927434 0.348 ENSMUST00000079279.3
Gm10118
predicted gene 10118
chr9_+_92309362 0.327 ENSMUST00000098477.1
ENSMUST00000150594.1
1700057G04Rik

RIKEN cDNA 1700057G04 gene

chr3_-_96197580 0.323 ENSMUST00000016087.3
Bola1
bolA-like 1 (E. coli)
chr16_-_17531019 0.315 ENSMUST00000142666.1
ENSMUST00000100125.3
Thap7

THAP domain containing 7

chr3_-_96905294 0.295 ENSMUST00000029738.7
Gpr89
G protein-coupled receptor 89
chr7_-_142661858 0.290 ENSMUST00000145896.2
Igf2
insulin-like growth factor 2
chr7_+_142533012 0.285 ENSMUST00000038675.6
Mrpl23
mitochondrial ribosomal protein L23
chr7_+_45062429 0.241 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
Nosip



nitric oxide synthase interacting protein



chr7_+_110768169 0.239 ENSMUST00000170374.1
Ampd3
adenosine monophosphate deaminase 3
chr8_+_120488416 0.237 ENSMUST00000034279.9
Gse1
genetic suppressor element 1
chr18_+_37655891 0.233 ENSMUST00000097608.2
3222401L13Rik
RIKEN cDNA 3222401L13 gene
chr11_-_115933464 0.215 ENSMUST00000021097.3
Recql5
RecQ protein-like 5
chr9_+_122351555 0.203 ENSMUST00000156520.1
Abhd5
abhydrolase domain containing 5
chr5_+_31452427 0.186 ENSMUST00000076264.4
Zfp512
zinc finger protein 512
chr7_-_45870928 0.182 ENSMUST00000146672.1
Grin2d
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
chr17_-_29007925 0.159 ENSMUST00000009138.5
ENSMUST00000119274.1
Stk38

serine/threonine kinase 38

chr3_-_95106907 0.135 ENSMUST00000107233.2
Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
chr1_+_139422196 0.124 ENSMUST00000039867.7
Zbtb41
zinc finger and BTB domain containing 41 homolog
chr9_-_107770945 0.101 ENSMUST00000183248.1
ENSMUST00000182022.1
ENSMUST00000035199.6
ENSMUST00000182659.1
Rbm5



RNA binding motif protein 5



chr5_+_34999111 0.086 ENSMUST00000114283.1
Rgs12
regulator of G-protein signaling 12
chr14_-_70323783 0.084 ENSMUST00000151011.1
Slc39a14
solute carrier family 39 (zinc transporter), member 14
chr19_-_7341792 0.084 ENSMUST00000164205.1
ENSMUST00000165286.1
ENSMUST00000168324.1
ENSMUST00000032557.8
Mark2



MAP/microtubule affinity-regulating kinase 2



chr7_-_130772652 0.079 ENSMUST00000057134.4
Etos1
ectopic ossification 1
chr2_-_165287755 0.078 ENSMUST00000109298.1
ENSMUST00000109299.1
ENSMUST00000130393.1
ENSMUST00000017808.7
ENSMUST00000131409.1
ENSMUST00000156134.1
ENSMUST00000133961.1
Slc35c2






solute carrier family 35, member C2






chr5_+_34999070 0.059 ENSMUST00000114280.1
Rgs12
regulator of G-protein signaling 12
chr2_-_67433181 0.056 ENSMUST00000180773.1
Gm26727
predicted gene, 26727
chr17_-_34862473 0.053 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
Cfb


complement factor B


chr7_+_30231884 0.051 ENSMUST00000019882.9
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr3_+_84952146 0.048 ENSMUST00000029727.7
Fbxw7
F-box and WD-40 domain protein 7
chr1_+_59256906 0.047 ENSMUST00000160662.1
ENSMUST00000114248.2
Cdk15

cyclin-dependent kinase 15

chr15_+_85510812 0.045 ENSMUST00000079690.2
Gm4825
predicted pseudogene 4825
chr8_+_9977707 0.039 ENSMUST00000139793.1
ENSMUST00000048216.5
Abhd13

abhydrolase domain containing 13

chr8_+_27042555 0.030 ENSMUST00000033875.8
ENSMUST00000098851.4
Prosc

proline synthetase co-transcribed

chr7_+_103550368 0.020 ENSMUST00000106888.1
Olfr613
olfactory receptor 613

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:0019732 antifungal humoral response(GO:0019732)
0.4 2.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.4 2.0 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.3 2.5 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.3 1.5 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.3 2.9 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.2 0.7 GO:0007525 somatic muscle development(GO:0007525)
0.2 1.2 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 1.5 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.2 0.5 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.2 0.9 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.4 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.1 12.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 1.2 GO:2000821 regulation of grooming behavior(GO:2000821)
0.1 0.4 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 3.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 0.8 GO:0023041 neuronal signal transduction(GO:0023041)
0.1 0.2 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.1 0.9 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 0.2 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 0.4 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.0 0.9 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 1.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 0.4 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.3 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.1 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 0.7 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.6 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.5 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.9 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 0.1 GO:0015786 UDP-glucose transport(GO:0015786)
0.0 0.2 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 1.5 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.1 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.0 1.1 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 1.2 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.2 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.0 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0043512 inhibin A complex(GO:0043512)
0.3 2.9 GO:0002116 semaphorin receptor complex(GO:0002116)
0.2 0.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 2.5 GO:0031045 dense core granule(GO:0031045)
0.1 1.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.1 GO:0071439 clathrin complex(GO:0071439)
0.1 11.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.5 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 3.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.3 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 4.1 GO:0043195 terminal bouton(GO:0043195)
0.0 3.3 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.2 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.4 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 1.6 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.0 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.3 2.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 1.2 GO:0008061 chitin binding(GO:0008061)
0.3 1.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.3 4.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.3 0.8 GO:0004556 alpha-amylase activity(GO:0004556)
0.2 0.9 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 2.9 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 0.7 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.2 2.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 1.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 1.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.4 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1 2.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.5 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.1 0.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.1 GO:0032183 SUMO binding(GO:0032183)
0.0 1.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.7 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.2 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 1.2 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.4 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.4 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.3 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.3 GO:0008308 voltage-gated anion channel activity(GO:0008308)
0.0 5.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.5 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 5.8 GO:0003779 actin binding(GO:0003779)
0.0 0.0 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 1.6 GO:0017124 SH3 domain binding(GO:0017124)