Motif ID: Hoxb2_Dlx2

Z-value: 0.964

Transcription factors associated with Hoxb2_Dlx2:

Gene SymbolEntrez IDGene Name
Dlx2 ENSMUSG00000023391.7 Dlx2
Hoxb2 ENSMUSG00000075588.5 Hoxb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx2mm10_v2_chr2_-_71546745_715467580.863.4e-21Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb2_Dlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_71528657 17.703 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr14_-_48665098 16.413 ENSMUST00000118578.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr3_+_122419772 14.066 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr18_-_80986578 12.996 ENSMUST00000057950.7
Sall3
sal-like 3 (Drosophila)
chr15_-_8710734 12.544 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_71546745 12.010 ENSMUST00000024159.6
Dlx2
distal-less homeobox 2
chr3_-_88410295 11.767 ENSMUST00000056370.7
Pmf1
polyamine-modulated factor 1
chr15_-_8710409 11.574 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_+_25773985 10.200 ENSMUST00000125667.1
Myo10
myosin X
chr19_-_59170978 9.943 ENSMUST00000172821.2
Vax1
ventral anterior homeobox containing gene 1
chr4_+_136143497 9.294 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr3_+_159839729 9.233 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr12_+_38780284 8.890 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chrX_-_60893430 8.801 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr6_-_124779686 8.738 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr16_+_45094036 8.658 ENSMUST00000061050.5
Ccdc80
coiled-coil domain containing 80
chr13_-_53473074 8.399 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr2_+_152754156 8.393 ENSMUST00000010020.5
Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr6_+_8948608 8.178 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr5_-_62765618 8.076 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.9 29.7 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.8 24.5 GO:0007638 mechanosensory behavior(GO:0007638)
6.0 24.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
5.3 21.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 14.1 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 13.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
2.9 11.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
3.6 10.7 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
1.2 9.9 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.7 9.5 GO:0007530 sex determination(GO:0007530)
0.6 9.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.7 9.2 GO:0031017 exocrine pancreas development(GO:0031017)
0.6 9.2 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.1 9.1 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
0.3 8.5 GO:0071398 cellular response to fatty acid(GO:0071398)
2.8 8.4 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
1.4 8.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
1.3 8.1 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 7.6 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 7.3 GO:0007059 chromosome segregation(GO:0007059)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 86.5 GO:0005634 nucleus(GO:0005634)
1.4 24.1 GO:0043205 fibril(GO:0043205)
0.1 22.4 GO:0005667 transcription factor complex(GO:0005667)
0.2 13.2 GO:0016459 myosin complex(GO:0016459)
2.0 11.8 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.7 10.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 10.4 GO:0005615 extracellular space(GO:0005615)
0.0 9.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 9.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 9.1 GO:0001750 photoreceptor outer segment(GO:0001750)
1.0 8.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
1.4 8.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 8.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.3 7.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 5.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 5.0 GO:0060077 inhibitory synapse(GO:0060077)
1.6 4.9 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.2 4.3 GO:0002102 podosome(GO:0002102)
2.0 4.0 GO:0071953 elastic fiber(GO:0071953)
0.3 3.7 GO:0005915 zonula adherens(GO:0005915)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 48.4 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 47.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
4.8 24.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 13.5 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.3 13.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.5 12.6 GO:0001968 fibronectin binding(GO:0001968)
0.2 12.3 GO:0030507 spectrin binding(GO:0030507)
0.1 12.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.9 11.8 GO:0043522 leucine zipper domain binding(GO:0043522)
2.3 11.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 11.3 GO:0030165 PDZ domain binding(GO:0030165)
1.3 10.7 GO:0050693 LBD domain binding(GO:0050693)
1.0 10.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
1.2 9.9 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.4 9.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 8.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.3 8.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.5 8.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.6 8.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.3 7.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)