Motif ID: Hoxc10

Z-value: 0.634


Transcription factors associated with Hoxc10:

Gene SymbolEntrez IDGene Name
Hoxc10 ENSMUSG00000022484.7 Hoxc10



Activity profile for motif Hoxc10.

activity profile for motif Hoxc10


Sorted Z-values histogram for motif Hoxc10

Sorted Z-values for motif Hoxc10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc10

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_159737510 8.451 ENSMUST00000111669.3
 Tnr
tenascin R
chr2_-_25469742 7.957 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr18_-_42899470 6.843 ENSMUST00000120632.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr13_-_84064772 6.636 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr18_-_42899294 6.607 ENSMUST00000117687.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr5_+_117841839 6.447 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr2_-_25470031 6.059 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr6_-_13839916 4.455 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr17_-_91092715 4.269 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr16_-_23988852 4.217 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr15_+_81936753 4.004 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr15_+_81936911 3.993 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr3_-_123672321 3.722 ENSMUST00000172537.1
ENSMUST00000029602.6
 Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr14_+_13454010 3.611 ENSMUST00000112656.2
 Synpr
synaptoporin
chr15_-_58214882 3.607 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr7_-_73537621 3.498 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chr3_+_108591279 3.453 ENSMUST00000051145.8
ENSMUST00000139626.1
 Wdr47

WD repeat domain 47

chr3_+_76074270 3.440 ENSMUST00000038364.8
 Fstl5
follistatin-like 5
chr4_+_144893127 3.280 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr17_-_90088343 3.083 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr1_+_194619815 3.036 ENSMUST00000027952.5
 Plxna2
plexin A2
chr1_+_66386968 2.986 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr5_-_62766153 2.887 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_-_144527341 2.858 ENSMUST00000163701.1
ENSMUST00000081982.5
 Dzank1

double zinc ribbon and ankyrin repeat domains 1

chr17_+_31433054 2.698 ENSMUST00000136384.1
 Pde9a
phosphodiesterase 9A
chr15_+_92597104 2.613 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr9_-_44799179 2.597 ENSMUST00000114705.1
ENSMUST00000002100.7
 Tmem25

transmembrane protein 25

chr2_+_178141920 2.589 ENSMUST00000103066.3
 Phactr3
phosphatase and actin regulator 3
chr14_+_13453937 2.580 ENSMUST00000153954.1
 Synpr
synaptoporin
chr10_-_49783259 2.400 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
 Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)



chr8_+_83666827 2.399 ENSMUST00000019608.5
 Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr15_+_21111452 2.389 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr11_-_79504078 2.335 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr9_+_113812547 2.056 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr2_+_32395896 1.962 ENSMUST00000028162.3
 Ptges2
prostaglandin E synthase 2
chr1_+_179961110 1.949 ENSMUST00000076687.5
ENSMUST00000097450.3
 Cdc42bpa

CDC42 binding protein kinase alpha

chr11_+_29463735 1.922 ENSMUST00000155854.1
 Ccdc88a
coiled coil domain containing 88A
chr5_+_71699918 1.910 ENSMUST00000031122.7
 Gabrb1
gamma-aminobutyric acid (GABA) A receptor, subunit beta 1
chr13_-_41273977 1.889 ENSMUST00000163881.1
 Gm17364
predicted gene, 17364
chr1_-_63114255 1.837 ENSMUST00000153992.1
ENSMUST00000165066.1
ENSMUST00000172416.1
ENSMUST00000137511.1
 Ino80d



INO80 complex subunit D



chr3_+_32436151 1.815 ENSMUST00000029201.7
 Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr1_+_180111339 1.757 ENSMUST00000145181.1
 Cdc42bpa
CDC42 binding protein kinase alpha
chr1_+_191025350 1.755 ENSMUST00000181050.1
 A230020J21Rik
RIKEN cDNA A230020J21 gene
chr18_-_6490808 1.666 ENSMUST00000028100.6
ENSMUST00000050542.5
 Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr13_+_104287855 1.549 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr15_+_100761741 1.515 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8
chr1_+_179960472 1.433 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr3_-_146770218 1.389 ENSMUST00000106137.1
 Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr6_-_136875794 1.258 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr5_-_111761697 1.209 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr9_+_50575273 1.203 ENSMUST00000059081.6
ENSMUST00000180021.1
 Il18

interleukin 18

chr8_-_41016295 1.105 ENSMUST00000131965.1
 Mtus1
mitochondrial tumor suppressor 1
chr7_-_29906087 1.095 ENSMUST00000053521.8
 Zfp27
zinc finger protein 27
chr4_-_110290884 1.024 ENSMUST00000142722.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr9_-_116175318 0.895 ENSMUST00000061101.4
ENSMUST00000035014.6
 Tgfbr2

transforming growth factor, beta receptor II

chr4_+_128759258 0.886 ENSMUST00000030585.7
 A3galt2
alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase)
chr1_-_69108039 0.849 ENSMUST00000121473.1
 Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr7_+_103550368 0.818 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr1_-_63114516 0.697 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr1_+_127729405 0.609 ENSMUST00000038006.6
 Acmsd
amino carboxymuconate semialdehyde decarboxylase
chr2_-_32451396 0.554 ENSMUST00000028160.8
ENSMUST00000113310.2
 Slc25a25

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25

chr8_+_25720054 0.520 ENSMUST00000068916.8
ENSMUST00000139836.1
 Ppapdc1b

phosphatidic acid phosphatase type 2 domain containing 1B

chr7_-_141435327 0.503 ENSMUST00000138865.1
 Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr2_+_130576170 0.495 ENSMUST00000028764.5
 Oxt
oxytocin
chr17_-_46680870 0.449 ENSMUST00000165007.1
ENSMUST00000071841.5
 Klhdc3

kelch domain containing 3

chr8_-_47352348 0.433 ENSMUST00000110367.2
 Stox2
storkhead box 2
chr2_-_27463994 0.326 ENSMUST00000164296.1
 Brd3
bromodomain containing 3
chr7_-_30729505 0.303 ENSMUST00000006478.8
 Tmem147
transmembrane protein 147
chr7_-_141434532 0.282 ENSMUST00000133021.1
ENSMUST00000106007.3
ENSMUST00000150026.1
ENSMUST00000133206.2
 Slc25a22



solute carrier family 25 (mitochondrial carrier, glutamate), member 22



chr11_-_97700327 0.273 ENSMUST00000018681.7
 Pcgf2
polycomb group ring finger 2
chr11_+_115933282 0.267 ENSMUST00000140991.1
 Sap30bp
SAP30 binding protein
chrM_+_3906 0.226 ENSMUST00000082396.1
 mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr7_-_31051431 0.221 ENSMUST00000073892.4
 Fxyd7
FXYD domain-containing ion transport regulator 7
chr11_+_94211431 0.213 ENSMUST00000041589.5
 Tob1
transducer of ErbB-2.1
chr17_-_78684262 0.192 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr5_-_62765618 0.167 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_17601893 0.131 ENSMUST00000088476.2
 Pi15
peptidase inhibitor 15
chr15_-_79062866 0.123 ENSMUST00000151889.1
ENSMUST00000040676.4
 Ankrd54

ankyrin repeat domain 54

chr8_-_94012558 0.088 ENSMUST00000053766.6
 Amfr
autocrine motility factor receptor
chr18_-_70141568 0.087 ENSMUST00000121693.1
 Rab27b
RAB27b, member RAS oncogene family
chr15_+_16778101 0.038 ENSMUST00000026432.6
 Cdh9
cadherin 9
chr1_-_97761538 0.030 ENSMUST00000171129.1
 Ppip5k2
diphosphoinositol pentakisphosphate kinase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.5 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
2.8 14.0 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.9 13.4 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
1.6 6.4 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
1.5 7.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
1.4 4.2 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
1.2 3.6 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.6 1.8 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.4 1.2 GO:0001866 NK T cell proliferation(GO:0001866) regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819)
0.3 2.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.3 0.6 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.3 0.9 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.3 3.3 GO:0042572 retinol metabolic process(GO:0042572)
0.3 3.0 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.2 5.1 GO:0007097 nuclear migration(GO:0007097)
0.2 2.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 1.9 GO:0071420 cellular response to histamine(GO:0071420)
0.2 3.5 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.2 0.9 GO:0030259 lipid glycosylation(GO:0030259)
0.2 0.8 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.2 0.5 GO:0042713 negative regulation of urine volume(GO:0035811) sperm ejaculation(GO:0042713) negative regulation of gastric acid secretion(GO:0060455)
0.1 2.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 1.4 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 2.0 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1 2.3 GO:0048679 regulation of axon regeneration(GO:0048679)
0.1 1.7 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 1.9 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.1 1.5 GO:0015701 bicarbonate transport(GO:0015701)
0.1 1.1 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 3.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.2 GO:1902373 negative regulation of mRNA catabolic process(GO:1902373)
0.0 0.6 GO:0002021 response to dietary excess(GO:0002021)
0.0 0.8 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.8 GO:0007608 sensory perception of smell(GO:0007608)
0.0 1.5 GO:0035904 aorta development(GO:0035904)
0.0 1.0 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.1 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 1.3 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 2.2 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.0 7.3 GO:0006397 mRNA processing(GO:0006397)
0.0 2.1 GO:0032496 response to lipopolysaccharide(GO:0032496)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.5 GO:0072534 perineuronal net(GO:0072534)
0.7 13.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.7 2.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.6 6.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.6 1.8 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.6 6.4 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.4 2.4 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.3 1.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.3 3.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 3.0 GO:0002116 semaphorin receptor complex(GO:0002116)
0.2 14.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 1.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 7.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.0 GO:0042788 polysomal ribosome(GO:0042788)
0.1 4.2 GO:0005657 replication fork(GO:0005657)
0.1 3.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 5.1 GO:0042641 actomyosin(GO:0042641)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 2.7 GO:0043204 perikaryon(GO:0043204)
0.0 1.2 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 1.7 GO:0005901 caveola(GO:0005901)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.2 GO:0030014 CCR4-NOT complex(GO:0030014)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 14.0 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
2.1 6.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
1.0 13.4 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.7 2.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.6 7.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.6 2.4 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.6 8.5 GO:0046625 sphingolipid binding(GO:0046625)
0.5 3.7 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.5 3.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 2.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.4 3.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.4 4.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.2 1.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 1.8 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.2 0.9 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 3.0 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 2.1 GO:0002162 dystroglycan binding(GO:0002162)
0.2 0.8 GO:0038132 neuregulin binding(GO:0038132)
0.2 2.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 0.9 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.1 2.7 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.8 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.9 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.1 1.9 GO:0043422 protein kinase B binding(GO:0043422)
0.1 1.5 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 3.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.8 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 1.0 GO:0017091 AU-rich element binding(GO:0017091)
0.0 4.5 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.3 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 3.8 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 1.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 3.1 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.6 GO:0016831 carboxy-lyase activity(GO:0016831)