Motif ID: Hoxc13_Hoxd13

Z-value: 0.836




Activity profile for motif Hoxc13_Hoxd13.

activity profile for motif Hoxc13_Hoxd13


Sorted Z-values histogram for motif Hoxc13_Hoxd13

Sorted Z-values for motif Hoxc13_Hoxd13



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc13_Hoxd13

PNG image of the network

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Top targets:


Showing 1 to 20 of 82 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_8518801 11.170 ENSMUST00000061601.7
 Ust
uronyl-2-sulfotransferase
chr1_-_56978534 8.401 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr16_-_74411776 6.220 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr6_+_108213086 6.138 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr5_+_17574268 6.102 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr17_+_75178911 5.863 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr4_+_54945038 5.526 ENSMUST00000133895.1
 Zfp462
zinc finger protein 462
chr17_+_75178797 5.087 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr17_-_6477102 5.036 ENSMUST00000167717.2
 Tmem181b-ps
transmembrane protein 181B, pseudogene
chr17_+_6270475 4.590 ENSMUST00000088940.4
 Tmem181a
transmembrane protein 181A
chr18_+_69346143 4.464 ENSMUST00000114980.1
 Tcf4
transcription factor 4
chr16_+_23226014 4.009 ENSMUST00000178797.1
 St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
chr7_-_73537621 3.868 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chr12_-_34528844 2.514 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr4_-_110290884 2.387 ENSMUST00000142722.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr11_+_77216180 1.966 ENSMUST00000037912.5
ENSMUST00000156488.1
 Ssh2

slingshot homolog 2 (Drosophila)

chr9_-_96719404 1.936 ENSMUST00000140121.1
 Zbtb38
zinc finger and BTB domain containing 38
chr8_+_83666827 1.904 ENSMUST00000019608.5
 Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr1_-_74124420 1.781 ENSMUST00000169786.1
 Tns1
tensin 1
chr9_-_96719549 1.773 ENSMUST00000128269.1
 Zbtb38
zinc finger and BTB domain containing 38

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.2 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 8.5 GO:0030010 establishment of cell polarity(GO:0030010)
0.5 8.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.1 6.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
1.0 6.1 GO:0042045 epithelial fluid transport(GO:0042045)
0.9 6.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 5.5 GO:0043392 negative regulation of DNA binding(GO:0043392)
1.5 4.6 GO:0009405 pathogenesis(GO:0009405)
0.9 4.6 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.4 4.5 GO:0042118 endothelial cell activation(GO:0042118)
0.2 4.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
1.0 4.0 GO:1990743 protein sialylation(GO:1990743)
0.0 3.7 GO:0006275 regulation of DNA replication(GO:0006275)
0.3 2.5 GO:0034983 peptidyl-lysine deacetylation(GO:0034983) regulation of skeletal muscle fiber development(GO:0048742)
0.0 2.4 GO:0043488 regulation of mRNA stability(GO:0043488)
0.1 2.0 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 1.9 GO:0032496 response to lipopolysaccharide(GO:0032496)
0.0 1.8 GO:0010761 fibroblast migration(GO:0010761)
0.1 1.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 1.5 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 10.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 10.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 6.2 GO:0030673 axolemma(GO:0030673)
2.0 6.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 5.2 GO:0000790 nuclear chromatin(GO:0000790)
0.3 4.6 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.4 4.0 GO:0000138 Golgi trans cisterna(GO:0000138)
0.2 2.4 GO:0042788 polysomal ribosome(GO:0042788)
0.1 2.2 GO:0043194 axon initial segment(GO:0043194)
0.0 1.9 GO:0072562 blood microparticle(GO:0072562)
0.0 1.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 1.4 GO:0016592 mediator complex(GO:0016592)
0.1 1.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.7 GO:0042734 presynaptic membrane(GO:0042734)
0.2 0.6 GO:0043512 inhibin A complex(GO:0043512)
0.1 0.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.4 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.2 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
2.7 10.9 GO:0050436 microfibril binding(GO:0050436)
0.0 8.8 GO:0003682 chromatin binding(GO:0003682)
0.7 6.2 GO:0008046 axon guidance receptor activity(GO:0008046)
2.0 6.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.6 6.1 GO:0038191 neuropilin binding(GO:0038191)
0.5 4.6 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.5 4.6 GO:0015643 toxic substance binding(GO:0015643)
1.1 4.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.8 4.0 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 3.9 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.1 3.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 2.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 2.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 2.4 GO:0017091 AU-rich element binding(GO:0017091)
0.5 1.9 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.0 1.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 1.4 GO:0070697 activin receptor binding(GO:0070697)
0.2 1.4 GO:0031432 titin binding(GO:0031432)
0.1 1.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)