Motif ID: Hoxc9

Z-value: 0.626


Transcription factors associated with Hoxc9:

Gene SymbolEntrez IDGene Name
Hoxc9 ENSMUSG00000036139.6 Hoxc9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hoxc9mm10_v2_chr15_+_102977032_1029770320.152.1e-01Click!


Activity profile for motif Hoxc9.

activity profile for motif Hoxc9


Sorted Z-values histogram for motif Hoxc9

Sorted Z-values for motif Hoxc9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_26516620 4.994 ENSMUST00000132820.1
 Notch1
notch 1
chr4_+_136143497 4.755 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr7_-_116038734 4.627 ENSMUST00000166877.1
 Sox6
SRY-box containing gene 6
chr2_+_70474923 4.230 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr9_+_35423582 3.961 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr17_-_49564262 3.536 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr10_-_13324160 3.049 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr1_-_45503282 2.998 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr2_+_102658640 2.724 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr10_-_13324250 2.532 ENSMUST00000105543.1
 Phactr2
phosphatase and actin regulator 2
chr2_+_91256144 2.425 ENSMUST00000154959.1
ENSMUST00000059566.4
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chrX_-_141474034 2.408 ENSMUST00000101205.2
 Col4a6
collagen, type IV, alpha 6
chr4_+_144893127 2.286 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_+_4710119 2.104 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr13_+_94083490 2.014 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr2_+_91255954 1.814 ENSMUST00000134699.1
 Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr17_+_24426676 1.691 ENSMUST00000024946.5
 Eci1
enoyl-Coenzyme A delta isomerase 1
chr4_+_107830958 1.631 ENSMUST00000106731.2
 Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr8_-_120228221 1.566 ENSMUST00000183235.1
 A330074K22Rik
RIKEN cDNA A330074K22 gene
chr16_-_37384915 1.564 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr1_+_58210397 1.332 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr5_-_44101668 1.220 ENSMUST00000087441.4
ENSMUST00000074113.6
 Prom1

prominin 1

chr11_-_80080928 1.144 ENSMUST00000103233.3
ENSMUST00000061283.8
 Crlf3

cytokine receptor-like factor 3

chr10_-_92162753 1.130 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr16_-_37384940 1.067 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr18_+_65582239 1.061 ENSMUST00000182684.1
 Zfp532
zinc finger protein 532
chr3_+_66985680 0.981 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr10_-_88605017 0.980 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr1_+_187997821 0.934 ENSMUST00000027906.6
 Esrrg
estrogen-related receptor gamma
chr18_+_65582281 0.929 ENSMUST00000183319.1
 Zfp532
zinc finger protein 532
chr8_-_105471481 0.916 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr19_-_10880370 0.882 ENSMUST00000133303.1
 Tmem109
transmembrane protein 109
chr1_+_187997835 0.869 ENSMUST00000110938.1
 Esrrg
estrogen-related receptor gamma
chr2_-_84650714 0.769 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
 Ctnnd1



















catenin (cadherin associated protein), delta 1



















chr2_-_84650760 0.740 ENSMUST00000111691.1
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr4_+_100776664 0.600 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chr6_-_119388671 0.573 ENSMUST00000169744.1
 Adipor2
adiponectin receptor 2
chr2_-_84650490 0.528 ENSMUST00000066177.3
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr2_-_84650676 0.492 ENSMUST00000067232.3
 Ctnnd1
catenin (cadherin associated protein), delta 1
chr9_-_89705017 0.481 ENSMUST00000058488.6
 Tmed3
transmembrane emp24 domain containing 3
chr11_+_3330401 0.479 ENSMUST00000045153.4
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr2_-_177578199 0.458 ENSMUST00000108945.1
ENSMUST00000108943.1
 Gm14406

predicted gene 14406

chr2_-_91255995 0.415 ENSMUST00000180732.1
 Gm17281
predicted gene, 17281
chr7_-_139582790 0.401 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr4_-_150003130 0.385 ENSMUST00000084117.6
 H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr3_+_66985647 0.377 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chrX_-_105928547 0.373 ENSMUST00000101305.2
 Atrx
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
chr2_+_175010241 0.367 ENSMUST00000109069.1
ENSMUST00000109070.2
 Gm14444

predicted gene 14444

chr5_+_67260696 0.363 ENSMUST00000161233.1
ENSMUST00000160352.1
 Tmem33

transmembrane protein 33

chr3_+_66985700 0.335 ENSMUST00000046542.6
ENSMUST00000162693.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr5_-_67427794 0.287 ENSMUST00000169190.1
 Bend4
BEN domain containing 4
chr11_-_94242701 0.274 ENSMUST00000061469.3
 Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr13_+_89540636 0.237 ENSMUST00000022108.7
 Hapln1
hyaluronan and proteoglycan link protein 1
chr15_+_8968389 0.206 ENSMUST00000053308.9
ENSMUST00000166524.1
 Ranbp3l

RAN binding protein 3-like

chrX_-_37104523 0.181 ENSMUST00000130324.1
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr9_-_7835255 0.177 ENSMUST00000074246.6
 Birc2
baculoviral IAP repeat-containing 2
chr2_+_4300462 0.167 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr18_+_65582390 0.167 ENSMUST00000169679.1
ENSMUST00000183326.1
 Zfp532

zinc finger protein 532

chr4_+_137594140 0.159 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
 Usp48



ubiquitin specific peptidase 48



chr10_-_67912620 0.158 ENSMUST00000064656.7
 Zfp365
zinc finger protein 365
chr13_+_113209659 0.108 ENSMUST00000038144.8
 Esm1
endothelial cell-specific molecule 1
chr2_-_128967725 0.084 ENSMUST00000099385.2
 Gm10762
predicted gene 10762
chr4_-_91376433 0.075 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chrX_-_143933089 0.075 ENSMUST00000087313.3
 Dcx
doublecortin
chr2_+_128967383 0.045 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chr7_-_30612731 0.036 ENSMUST00000006476.4
 Upk1a
uroplakin 1A
chrX_+_56609751 0.027 ENSMUST00000144068.1
 Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr17_-_57000018 0.016 ENSMUST00000002740.2
 Pspn
persephin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
1.0 3.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.5 2.1 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.5 2.5 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.5 4.0 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.5 2.7 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.4 1.3 GO:0046110 xanthine metabolic process(GO:0046110)
0.4 4.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.4 1.2 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.2 2.3 GO:0042572 retinol metabolic process(GO:0042572)
0.2 4.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 4.8 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.2 1.6 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.2 2.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.2 4.2 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.2 0.5 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.4 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.1 0.6 GO:0061042 vascular wound healing(GO:0061042)
0.1 0.2 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.1 0.2 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.1 0.4 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.2 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 2.6 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 1.7 GO:0046677 response to antibiotic(GO:0046677)
0.0 1.1 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.0 1.8 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.9 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.1 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.4 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 1.8 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.9 GO:0046785 microtubule polymerization(GO:0046785)
0.0 1.0 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0005588 collagen type V trimer(GO:0005588)
1.0 5.0 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.5 2.4 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.4 1.2 GO:0071914 prominosome(GO:0071914)
0.2 2.5 GO:0005915 zonula adherens(GO:0005915)
0.1 1.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.4 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1 2.7 GO:0030673 axolemma(GO:0030673)
0.0 2.6 GO:0031201 SNARE complex(GO:0031201)
0.0 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 4.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 1.7 GO:0016607 nuclear speck(GO:0016607)
0.0 0.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.2 GO:0035145 exon-exon junction complex(GO:0035145)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.7 2.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 1.6 GO:0038025 reelin receptor activity(GO:0038025)
0.3 1.7 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.3 1.3 GO:0030151 molybdenum ion binding(GO:0030151)
0.3 2.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 4.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 5.0 GO:0005112 Notch binding(GO:0005112)
0.2 0.5 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.6 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 0.4 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.1 4.8 GO:0005504 fatty acid binding(GO:0005504)
0.1 1.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 3.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.4 GO:0015616 DNA translocase activity(GO:0015616)
0.0 1.2 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.0 3.5 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 2.6 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 2.5 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.2 GO:0070412 R-SMAD binding(GO:0070412)