Motif ID: Hoxd10

Z-value: 0.376


Transcription factors associated with Hoxd10:

Gene SymbolEntrez IDGene Name
Hoxd10 ENSMUSG00000050368.3 Hoxd10



Activity profile for motif Hoxd10.

activity profile for motif Hoxd10


Sorted Z-values histogram for motif Hoxd10

Sorted Z-values for motif Hoxd10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd10

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_84773381 7.764 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr9_+_27790947 7.668 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr3_-_80802789 5.427 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr4_+_102254993 3.151 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr3_+_55461758 2.952 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chrX_-_70365052 2.358 ENSMUST00000101509.2
 Ids
iduronate 2-sulfatase
chr2_+_65620829 2.130 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr8_-_109251698 1.949 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr7_+_96210107 1.879 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chrX_+_66653003 1.875 ENSMUST00000036043.4
 Slitrk2
SLIT and NTRK-like family, member 2
chr15_+_9140527 1.539 ENSMUST00000090380.4
 Lmbrd2
LMBR1 domain containing 2
chr3_+_86084434 1.397 ENSMUST00000107664.2
 Sh3d19
SH3 domain protein D19
chr10_+_116177351 1.304 ENSMUST00000155606.1
ENSMUST00000128399.1
 Ptprr

protein tyrosine phosphatase, receptor type, R

chr7_+_30095150 1.117 ENSMUST00000130526.1
ENSMUST00000108200.1
 Zfp260

zinc finger protein 260

chr10_+_69534039 1.108 ENSMUST00000182557.1
 Ank3
ankyrin 3, epithelial
chr4_+_43401232 1.063 ENSMUST00000125399.1
 Rusc2
RUN and SH3 domain containing 2
chr14_-_93888732 0.956 ENSMUST00000068992.2
 Pcdh9
protocadherin 9
chr1_+_180111339 0.882 ENSMUST00000145181.1
 Cdc42bpa
CDC42 binding protein kinase alpha
chr2_+_21367532 0.838 ENSMUST00000055946.7
 Gpr158
G protein-coupled receptor 158
chr9_+_104569671 0.797 ENSMUST00000057742.8
 Cpne4
copine IV
chr2_+_106693185 0.781 ENSMUST00000111063.1
 Mpped2
metallophosphoesterase domain containing 2
chr6_+_33249085 0.773 ENSMUST00000052266.8
ENSMUST00000090381.4
ENSMUST00000115080.1
 Exoc4


exocyst complex component 4


chr9_+_95857597 0.678 ENSMUST00000034980.7
 Atr
ataxia telangiectasia and Rad3 related
chr17_-_78684262 0.613 ENSMUST00000145480.1
 Strn
striatin, calmodulin binding protein
chr18_-_78123324 0.574 ENSMUST00000160292.1
ENSMUST00000091813.5
 Slc14a1

solute carrier family 14 (urea transporter), member 1

chr1_-_152625212 0.513 ENSMUST00000027760.7
 Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr17_-_46327949 0.484 ENSMUST00000047970.7
 Abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr18_-_6490808 0.470 ENSMUST00000028100.6
ENSMUST00000050542.5
 Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr7_-_73541738 0.459 ENSMUST00000169922.2
 Chd2
chromodomain helicase DNA binding protein 2
chr1_-_132390301 0.450 ENSMUST00000132435.1
 Tmcc2
transmembrane and coiled-coil domains 2
chr10_-_49783259 0.400 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
 Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)



chr6_-_28397999 0.298 ENSMUST00000035930.4
 Zfp800
zinc finger protein 800
chr13_+_40917626 0.252 ENSMUST00000067778.6
 Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr4_+_19605451 0.225 ENSMUST00000108250.2
 Gm12353
predicted gene 12353
chr12_+_55089202 0.218 ENSMUST00000021407.10
 Srp54a
signal recognition particle 54A
chr11_-_110168073 0.179 ENSMUST00000044850.3
 Abca9
ATP-binding cassette, sub-family A (ABC1), member 9
chr18_-_75697639 0.170 ENSMUST00000165559.1
 Ctif
CBP80/20-dependent translation initiation factor
chr6_-_92481343 0.094 ENSMUST00000113445.1
 Prickle2
prickle homolog 2 (Drosophila)
chr12_+_76417598 0.089 ENSMUST00000063977.7
 Ppp1r36
protein phosphatase 1, regulatory subunit 36
chr5_+_121777929 0.001 ENSMUST00000160821.1
 Atxn2
ataxin 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 7.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.5 2.1 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.5 1.9 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.3 1.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.2 5.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2 3.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 0.7 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 1.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.8 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.1 0.6 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.1 3.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 1.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.9 GO:0007097 nuclear migration(GO:0007097)
0.0 0.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.0 0.5 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 1.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.4 GO:0032279 asymmetric synapse(GO:0032279)
0.1 3.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.8 GO:0032584 growth cone membrane(GO:0032584)
0.1 0.4 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.7 GO:0001741 XY body(GO:0001741)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 1.0 GO:0044291 cell-cell contact zone(GO:0044291)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 2.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.2 2.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.7 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.1 0.6 GO:0015265 urea channel activity(GO:0015265)
0.1 0.5 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 3.2 GO:0030552 cAMP binding(GO:0030552)
0.1 1.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 1.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.8 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.0 1.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)