Motif ID: Hoxd12

Z-value: 1.039


Transcription factors associated with Hoxd12:

Gene SymbolEntrez IDGene Name
Hoxd12 ENSMUSG00000001823.4 Hoxd12



Activity profile for motif Hoxd12.

activity profile for motif Hoxd12


Sorted Z-values histogram for motif Hoxd12

Sorted Z-values for motif Hoxd12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd12

PNG image of the network

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Top targets:


Showing 1 to 20 of 122 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_8710734 15.146 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 13.485 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr13_-_84064772 9.493 ENSMUST00000182477.1
Gm17750
predicted gene, 17750
chr4_-_154636831 8.673 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
Prdm16






PR domain containing 16






chr4_+_144893127 8.466 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 8.393 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr2_+_73271925 6.755 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr16_+_42907563 6.636 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr4_+_144893077 6.300 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_+_122419772 6.299 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr5_-_62766153 5.671 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_159737510 5.306 ENSMUST00000111669.3
Tnr
tenascin R
chr1_-_56969864 4.870 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr10_-_42583628 4.865 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr19_+_55741810 4.175 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr1_-_45503282 4.065 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr1_-_163313661 3.875 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr5_-_62765618 3.476 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_56969827 3.409 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr1_-_165934900 3.331 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.2 28.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
2.1 23.2 GO:0042572 retinol metabolic process(GO:0042572)
0.7 10.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.2 8.7 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.2 6.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 6.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.3 5.9 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 5.6 GO:0046677 response to antibiotic(GO:0046677)
1.8 5.3 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 5.2 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
0.6 5.0 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
1.0 4.9 GO:0021764 amygdala development(GO:0021764)
1.4 4.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.7 3.3 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.5 3.2 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.3 2.8 GO:0048664 neuron fate determination(GO:0048664)
0.4 2.6 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 2.4 GO:0030901 midbrain development(GO:0030901)
0.1 2.3 GO:0035493 SNARE complex assembly(GO:0035493)
0.7 2.2 GO:0061043 regulation of vascular wound healing(GO:0061043)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 28.6 GO:0043205 fibril(GO:0043205)
0.1 8.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 8.4 GO:0000118 histone deacetylase complex(GO:0000118)
1.8 5.3 GO:0072534 perineuronal net(GO:0072534)
0.6 5.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
1.4 4.1 GO:0005588 collagen type V trimer(GO:0005588)
0.1 2.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.5 2.3 GO:0070820 tertiary granule(GO:0070820)
0.1 2.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 2.1 GO:0016605 PML body(GO:0016605)
0.0 1.9 GO:0030175 filopodium(GO:0030175)
0.1 1.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.3 GO:0043596 nuclear replication fork(GO:0043596)
0.2 1.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 1.1 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.2 0.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.8 GO:0005882 intermediate filament(GO:0005882)
0.1 0.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.7 GO:0030056 hemidesmosome(GO:0030056)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.7 28.6 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
3.3 23.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 15.0 GO:0046332 SMAD binding(GO:0046332)
0.1 10.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 9.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 8.4 GO:0003682 chromatin binding(GO:0003682)
0.0 6.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.4 5.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.4 5.3 GO:0046625 sphingolipid binding(GO:0046625)
0.2 4.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 3.9 GO:0071837 HMG box domain binding(GO:0071837)
0.5 2.6 GO:0038132 neuregulin binding(GO:0038132)
0.2 2.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.4 2.5 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 2.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.7 2.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.6 2.2 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 2.2 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.2 2.0 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.9 GO:0042043 neurexin family protein binding(GO:0042043)