Motif ID: Hoxd12
Z-value: 1.039
Transcription factors associated with Hoxd12:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxd12 | ENSMUSG00000001823.4 | Hoxd12 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.2 | 28.6 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 2.1 | 23.2 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 1.8 | 5.3 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 1.4 | 4.1 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 1.2 | 8.7 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 1.0 | 4.9 | GO:0021764 | amygdala development(GO:0021764) |
| 0.7 | 2.2 | GO:0061043 | regulation of vascular wound healing(GO:0061043) |
| 0.7 | 10.3 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.7 | 3.3 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.6 | 5.0 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
| 0.5 | 3.2 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.4 | 1.3 | GO:0036292 | DNA rewinding(GO:0036292) |
| 0.4 | 2.6 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.4 | 1.9 | GO:0007262 | STAT protein import into nucleus(GO:0007262) |
| 0.3 | 1.3 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
| 0.3 | 5.9 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.3 | 1.1 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.3 | 1.0 | GO:0061042 | vascular wound healing(GO:0061042) |
| 0.3 | 2.8 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.2 | 2.2 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.2 | 0.7 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 0.2 | 2.2 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.2 | 6.3 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.2 | 0.8 | GO:0035878 | nail development(GO:0035878) |
| 0.2 | 0.8 | GO:0006526 | arginine biosynthetic process(GO:0006526) |
| 0.2 | 5.6 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.2 | 6.6 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.2 | 0.5 | GO:0046101 | hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) |
| 0.2 | 0.7 | GO:0002339 | B cell selection(GO:0002339) |
| 0.2 | 0.6 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 2.3 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.1 | 0.2 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
| 0.1 | 0.9 | GO:2000809 | positive regulation of synaptic vesicle clustering(GO:2000809) |
| 0.1 | 1.1 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.1 | 0.5 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.1 | 0.7 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.1 | 0.4 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.1 | 1.9 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.1 | 2.4 | GO:0030901 | midbrain development(GO:0030901) |
| 0.1 | 1.5 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.1 | 0.5 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.1 | 0.3 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.1 | 0.4 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.0 | 0.6 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.0 | 0.5 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.6 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.0 | 5.2 | GO:0030326 | embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113) |
| 0.0 | 0.8 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.0 | 0.4 | GO:0032148 | activation of protein kinase B activity(GO:0032148) |
| 0.0 | 0.1 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 0.1 | GO:0007379 | segment specification(GO:0007379) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.3 | GO:0072534 | perineuronal net(GO:0072534) |
| 1.7 | 28.6 | GO:0043205 | fibril(GO:0043205) |
| 1.4 | 4.1 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.6 | 5.0 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.5 | 2.3 | GO:0070820 | tertiary granule(GO:0070820) |
| 0.2 | 1.1 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 0.2 | 0.9 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 8.4 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 0.5 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.1 | 2.6 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 2.2 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.1 | 0.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 0.4 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.1 | 8.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 1.3 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.1 | 0.7 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 0.2 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 1.3 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 0.6 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.5 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.5 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 2.1 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 1.9 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 1.1 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 0.0 | 0.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.1 | GO:0030057 | desmosome(GO:0030057) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 28.6 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 3.3 | 23.2 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.7 | 2.2 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.6 | 2.2 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
| 0.5 | 2.6 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.4 | 1.3 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.4 | 2.5 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.4 | 5.9 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.4 | 5.3 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.3 | 1.0 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
| 0.2 | 9.1 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.2 | 0.8 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.2 | 2.6 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.2 | 2.0 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.2 | 4.3 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.1 | 3.9 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 0.9 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 15.0 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.1 | 0.5 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.1 | 0.8 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
| 0.1 | 1.5 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.1 | 1.3 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.1 | 1.9 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 2.2 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) |
| 0.1 | 1.1 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.1 | 10.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 0.7 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 2.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.7 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.0 | 6.6 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 0.4 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 0.4 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.0 | 1.9 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 8.4 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 0.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.2 | GO:0071949 | FAD binding(GO:0071949) |
| 0.0 | 0.5 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.8 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
